Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Katrin E. Wiese"'
Autor:
Rineke de Jong, Wout Nuiten, Albertjan ter Heide, Wilfred Hamstra, Sandra Vreman, Nadia Oreshkova, Katrin E. Wiese, Nora M. Gerhards
Publikováno v:
Viruses, Vol 16, Iss 7, p 1022 (2024)
Pulmonary function examinations are critical to assess respiratory disease severity in patients. In preclinical rodent models of viral respiratory infections, however, disease is frequently evaluated based on virological, pathological and/or surrogat
Externí odkaz:
https://doaj.org/article/84dfa31aa4f34eb785cf4d34892bab53
Autor:
Maarten Swart, Joan van der Lubbe, Sonja Schmit-Tillemans, Ella van Huizen, Johan Verspuij, Ana Izquierdo Gil, Ying Choi, Chenandly Daal, Aditya Perkasa, Adriaan de Wilde, Erwin Claassen, Rineke de Jong, Katrin E. Wiese, Lisette Cornelissen, Marieke van Es, Marjolein van Heerden, Eleni Kourkouta, Issam Tahiri, Michel Mulders, Jessica Vreugdenhil, Karin Feddes - de Boer, Leacky Muchene, Jeroen Tolboom, Liesbeth Dekking, Jarek Juraszek, Jort Vellinga, Jerome Custers, Rinke Bos, Hanneke Schuitemaker, Frank Wegmann, Ramon Roozendaal, Harmjan Kuipers, Roland Zahn
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Since the original outbreak of the SARS-CoV-2 virus, several rapidly spreading SARS-CoV-2 variants of concern (VOC) have emerged. Here, we show that a single dose of Ad26.COV2.S (based on the Wuhan-Hu-1 spike variant) protects against the Ga
Externí odkaz:
https://doaj.org/article/225f12fc050d4eedbec35ffc6652125e
Autor:
Nathiya Muthalagu, Melissa R. Junttila, Katrin E. Wiese, Elmar Wolf, Jennifer Morton, Barbara Bauer, Gerard I. Evan, Martin Eilers, Daniel J. Murphy
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1347-1353 (2014)
MYC is one of the most frequently overexpressed oncogenes in human cancer, and even modestly deregulated MYC can initiate ectopic proliferation in many postmitotic cell types in vivo. Sensitization of cells to apoptosis limits MYC’s oncogenic poten
Externí odkaz:
https://doaj.org/article/fdf0d4be4c9a4d9ea8e87bb356646b6b
Autor:
Amber Lisanne Zeeman, Bongaarts A, Mora Martinez I, Larissa Mourao, Jos Jonkers, Katrin E. Wiese, van de Grift Yb, van Amerongen R, Oudejans Ll
In the past forty years, the WNT/CTNNB1 signaling pathway has emerged as a key player in mammary gland development and homeostasis. While also evidently involved in breast cancer, much unclarity continues to surround its precise role in mammary tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72a3442ff93865187ebb52f142569e89
https://doi.org/10.1101/2021.06.22.449461
https://doi.org/10.1101/2021.06.22.449461
Publikováno v:
Cell Cycle. 15:316-323
Apoptosis caused by deregulated MYC expression is a prototype example of intrinsic tumor suppression. However, it is still unclear how supraphysiological MYC expression levels engage specific sets of target genes to promote apoptosis. Recently, we de
Autor:
Leigh-Anne McDuffus, Markus Sauer, Björn von Eyss, Laura A. Jaenicke, Martin Eilers, Sebastian Letschert, Roderik M. Kortlever, Nadine Royla, Stefan Kempa, Andreas Rosenwald, Katrin E. Wiese, Gerard I. Evan
Publikováno v:
Cancer Cell. 28:743-757
In several developmental lineages, an increase in MYC expression drives the transition from quiescent stem cells to transit-amplifying cells. We show that MYC activates a stereotypic transcriptional program of genes involved in cell growth in mammary
Autor:
Richard Treisman, Bjoern von Eyss, Cyril Esnault, Andreas Rosenwald, Elmar Wolf, Heidi M. Haikala, Martin Eilers, Katrin E. Wiese, Juha Klefström
Publikováno v:
EMBO Journal
EMBO Journal, EMBO Press, 2015, 34 (11), pp.1554-71. ⟨10.15252/embj.201490467⟩
EMBO Journal, EMBO Press, 2015, 34 (11), pp.1554-71. ⟨10.15252/embj.201490467⟩
International audience; Oncogenic levels of Myc expression sensitize cells to multiple apoptotic stimuli, and this protects long-lived organisms from cancer development. How cells discriminate physiological from supraphysiological levels of Myc is la
Publikováno v:
Breast Cancer Research
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Mammary gland biologists gathered for the ninth annual workshop of the European Network for Breast Development and Cancer (ENBDC) at Weggis on the shores of Lake Lucerne in March 2017. The main themes were oestrogen receptor alpha signalling, new tec
Autor:
Gerard I. Evan, Daniel J. Murphy, Martin Eilers, Katrin E. Wiese, Nathiya Muthalagu, B. Bauer, Elmar Wolf, Melissa R. Junttila, Jennifer P. Morton
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1347-1353 (2014)
SummaryMYC is one of the most frequently overexpressed oncogenes in human cancer, and even modestly deregulated MYC can initiate ectopic proliferation in many postmitotic cell types in vivo. Sensitization of cells to apoptosis limits MYC’s oncogeni
Autor:
Frederik Roels, Lukas Rycak, Chia-Lin Wei, Steffi Herold, Björn von Eyss, Hélène Dumay-Odelot, Jennifer P. Morton, Owen J. Sansom, Marek Bartkuhn, Saadia A. Karim, Elmar Wolf, Matthias Fischer, Martin Teichmann, Katrin E. Wiese, Francesca Lorenzin, Lars Zender, Martin Eilers, Torsten Wüstefeld, Susanne Walz
Publikováno v:
Nature. 511:483-487
In mammalian cells, the MYC oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, MYC promotes an increase in the expression of virtually all genes. In contrast, MYC-driven tumour cells differ from normal c