Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Katrin Bennewitz"'
Autor:
Xin Qian, Stephan Klatt, Katrin Bennewitz, David Philipp Wohlfart, Bowen Lou, Ye Meng, Michael Buettner, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ingrid Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Advanced Science, Vol 11, Iss 4, Pp n/a-n/a (2024)
Abstract Omega‐6 fatty acids are the primary polyunsaturated fatty acids in most Western diets, while their role in diabetes remains controversial. Exposure of omega‐6 fatty acids to an oxidative environment results in the generation of a highly
Externí odkaz:
https://doaj.org/article/d3e9abcfffc843caa8b54bf9e9a82f24
Autor:
Bowen Lou, Haoyu Wu, Hannes Ott, Katrin Bennewitz, Chen Wang, Gernot Poschet, Hui Liu, Zuyi Yuan, Jens Kroll, Jianqing She
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulatory element binding p
Externí odkaz:
https://doaj.org/article/57b81c6c80614279a17b07c0f715d412
Autor:
Christoph Tobias Tabler, Elisabeth Lodd, Katrin Bennewitz, Chiara Simone Middel, Vanessa Erben, Hannes Ott, Tanja Poth, Thomas Fleming, Jakob Morgenstern, Ingrid Hausser, Carsten Sticht, Gernot Poschet, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102576- (2023)
Glyoxalase 2 is the second enzyme of the glyoxalase system, catalyzing the detoxification of methylglyoxal to d-lactate via SD-Lactoylglutathione. Recent in vitro studies have suggested Glo2 as a regulator of glycolysis, but if Glo2 regulates glucose
Externí odkaz:
https://doaj.org/article/8ec9121e06394c43ad839a73926f3863
Autor:
Haozhe Qi, Kejia Kan, Carsten Sticht, Katrin Bennewitz, Shu Li, Xin Qian, Gernot Poschet, Jens Kroll
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
IntroductionDiabetes mellitus (DM) is associated with physiological disorders such as delayed wound healing, diabetic retinopathy, diabetic nephropathy, and diabetic peripheral neuropathy (DPN). Over 50% of diabetic patients will develop DPN, charact
Externí odkaz:
https://doaj.org/article/96ce8bb5d0794433b7d077a97ffed98b
Autor:
Mike Boger, Katrin Bennewitz, David Philipp Wohlfart, Ingrid Hausser, Carsten Sticht, Gernot Poschet, Jens Kroll
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The ELMO protein family consists of the homologues ELMO1, ELMO2 and ELMO3. Several studies have shown that the individual ELMO proteins are involved in a variety of cellular and developmental processes. However, it has poorly been understood whether
Externí odkaz:
https://doaj.org/article/476afd81cd3c49278f0524bf3f329dfe
Autor:
Hagen M. Gegner, Nils Mechtel, Elena Heidenreich, Angela Wirth, Fabiola Garcia Cortizo, Katrin Bennewitz, Thomas Fleming, Carolin Andresen, Marc Freichel, Aurelio A. Teleman, Jens Kroll, Rüdiger Hell, Gernot Poschet
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Metabolic profiling harbors the potential to better understand various disease entities such as cancer, diabetes, Alzheimer’s, Parkinson’s disease or COVID-19. To better understand such diseases and their intricate metabolic pathways in human stu
Externí odkaz:
https://doaj.org/article/1071d247f0c043dca734c40fef308b52
Autor:
Haozhe Qi, Felix Schmöhl, Xiaogang Li, Xin Qian, Christoph T. Tabler, Katrin Bennewitz, Carsten Sticht, Jakob Morgenstern, Thomas Fleming, Nadine Volk, Ingrid Hausser, Elena Heidenreich, Rüdiger Hell, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Advanced Science, Vol 8, Iss 18, Pp n/a-n/a (2021)
Abstract Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications. However, the molecular mechanisms are mostly unknown, and a suitable animal model with internal increased ACR do
Externí odkaz:
https://doaj.org/article/5965a1df7cfd4a61ae1372f68cdba8f5
Autor:
Xiaogang Li, Felix Schmöhl, Haozhe Qi, Katrin Bennewitz, Christoph T. Tabler, Gernot Poschet, Rüdiger Hell, Nadine Volk, Tanja Poth, Ingrid Hausser, Jakob Morgenstern, Thomas Fleming, Peter Paul Nawroth, Jens Kroll
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101763- (2020)
Summary: Regulation of glucose homeostasis is a fundamental process to maintain blood glucose at a physiological level, and its dysregulation is associated with the development of several metabolic diseases. Here, we report on a zebrafish mutant for
Externí odkaz:
https://doaj.org/article/8038c2712d2741548133c7a0daabb4b8
Autor:
Bowen Lou, Mike Boger, Katrin Bennewitz, Carsten Sticht, Stefan Kopf, Jakob Morgenstern, Thomas Fleming, Rüdiger Hell, Zuyi Yuan, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101723- (2020)
Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG detoxifying system Glyoxalase 1, led to limited MG elevation but significantly elevated aldehyde dehydrogenases (ALDH) act
Externí odkaz:
https://doaj.org/article/72bf44548f7d4df986b82bce975c982f
Autor:
Franziska J. Heinkele, Bowen Lou, Vanessa Erben, Katrin Bennewitz, Gernot Poschet, Carsten Sticht, Jens Kroll
Publikováno v:
Antioxidants, Vol 10, Iss 10, p 1581 (2021)
Obesity is a worldwide public health problem with increasing prevalence and affects 80% of diabetes mellitus type 2 cases. Zebrafish (Danio rerio) is an established model organism for studying obesity and diabetes including diabetic microvascular com
Externí odkaz:
https://doaj.org/article/bd4baf6049b74645af9628168b106a19