Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Katrin Kinkel"'
1
Design, Synthesis, and Biological Evaluation of Novel 3-Aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as Vascular Endothelial Growth Factor Receptor (VEGF-R) Inhibitors
Autor: Regina Heidenreich, Katrin Kinkel, Frank Totzke, Stefan Laufer, Dieter Schollmeyer, Dimitri Ott, Christian Peifer, Martin Röcken, Christoph Schächtele, Roland Selig
Publikováno v: Journal of Medicinal Chemistry. 51:3814-3824
In this study we report on the design, synthesis, and biological evaluation of pyrrole-2-one 2 to be a highly potent VEGF-R2/3 inhibitor with IC 50 of 31/37 nM. The novel 3,4-diaryl-2 H-pyrrole-2-ones were designed on the basis of the modeled binding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3dc1c99eef92b5058768e496f1d073
https://doi.org/10.1021/jm8001185
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2
From Five- to Six-Membered Rings: 3,4-Diarylquinolinone as Lead for Novel p38MAP Kinase Inhibitors
Autor: Katrin Kinkel, Christian Peifer, Mohammed M. Abadleh, Dieter Schollmeyer, Stefan Laufer
Publikováno v: Journal of Medicinal Chemistry. 50:1213-1221
In this study we describe the design, synthesis, and biological evaluation of 3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (5) as a new inhibitor of MAPK with a p38alphaMAPK IC50 of 1.8 muM. By keeping the common vicinal pyridine/4-F-phenyl p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd07e1ddcf52904d6e0958d2bbb81977
https://doi.org/10.1021/jm061097o
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3
3-(4-Fluorophenyl)-1-methyl-4-(4-pyridyl)quinolin-2(1H)-one
Autor: Dieter Schollmeyer, Katrin Kinkel, Stefan Laufer, Christian Peifer
Publikováno v: Acta Crystallographica Section E Structure Reports Online. 63:o2457-o2459
The title compound, C21H15FN2O, was synthesized in the course of our studies of p38 mitogen-activated protein kinase inhibitors. It has been investigated by 1H and 13C NMR spectroscopy and was proven by X-ray crystallographic analysis to be the N-met
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cd5ea270eaf985f7af8ad783b0026c3
https://doi.org/10.1107/s1600536807014638
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4
2,2-Dimethyl-N-[3-(3,4,5-trimethoxybenzoyl)pyridin-4-yl]propanamide
Autor: Christian Peifer, Katrin Kinkel, Stefan Laufer, Dieter Schollmeyer
Publikováno v: Acta Crystallographica Section E Structure Reports Online. 63:o1887-o1889
The title compound, C20H24N2O5, was found to have an intra­molecular N—H⋯O bond with an N⋯O distance of 2.646 (2) A. In the crystal structure, mol­ecules form dimers along the c axis by aromatic stacking inter­actions. The X-ray crystallogra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52d840fc78b94f13c0310dc24930c450
https://doi.org/10.1107/s1600536807012500
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5
4-[5-(4-Fluorophenyl)-3-isopropylisoxazol-4-yl]pyridin-2(1H)-one
Autor: Christian Peifer, Dieter Schollmeyer, Katrin Kinkel, Stefan Laufer, Mohammed Abadleh
Publikováno v: Acta Crystallographica Section E Structure Reports Online. 63:o1423-o1425
The crystal structure of the title compound, C17H15FN2O2, was determined as part of a study of the biological activity of pyridine-substituted isoxazole derivatives as mitogen-activated protein kinase (MAPK) inhibitors. In the crystal structure of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::563049b6f1cadd3c4c0f1766657eea53
https://doi.org/10.1107/s1600536807007933
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6
Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region
Autor: Dominik Hauser, David M Domeyer, Katrin Kinkel, Stefan Laufer, Andy J. Liedtke
Publikováno v: Journal of medicinal chemistry. 51(14)
The synthesis, biological testing, and SAR of novel 2,4,5- and 1,2,4,5-substituted 2-thioimidazoles are described. Amino, oxy, or thioxy substituents at the 2-position of the pyridinyl moiety were evaluated for their contributions to inhibitor potenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f7dd5f04d4daff21767d065ed1eab6
https://pubmed.ncbi.nlm.nih.gov/18578517
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7
Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
Autor: Katrin Kinkel, Christian Peifer, Stefan Laufer, Frank Totzke, Stefanie Bühler, Christoph Schächtele, Dominik Hauser
Publikováno v: European journal of medicinal chemistry. 44(4)
In this study we report on the design, synthesis and biological characterization of novel N(9) or N(7) arylethanone-substituted 6-aminopurines and 6-methoxypurines, respectively, as EGF-R and VEGF-R inhibitors. The compounds were initially profiled i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5435786a3a160b574bdfe52b6a47da
https://pubmed.ncbi.nlm.nih.gov/18524423
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10
Akademický článek
From Five- to Six-Membered Rings:  3,4-Diarylquinolinone as Lead for Novel p38MAP Kinase Inhibitors.
Autor: Christian Peifer, Katrin Kinkel, Mohammed Abadleh, Dieter Schollmeyer, Stefan Laufer
Publikováno v: Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 6, p1213-1221, 9p
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