Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Katrin, Paeschke"'
Autor:
Sarah Rösing, Fabian Ullrich, Susann Meisterfeld, Franziska Schmidt, Laura Mlitzko, Marijana Croon, Ryan G Nattrass, Nadia Eberl, Julia Mahlberg, Martin Schlee, Anja Wieland, Philipp Simon, Daniel Hilbig, Ulrike Reuner, Alexander Rapp, Julia Bremser, Peter Mirtschink, Stephan Drukewitz, Thomas Zillinger, Stefan Beissert, Katrin Paeschke, Gunther Hartmann, Aleksandra Trifunovic, Eva Bartok, Claudia Günther
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Myotonic dystrophy type 2 (DM2) is a tetranucleotide CCTG repeat expansion disease associated with an increased prevalence of autoimmunity. Here, we identified an elevated type I interferon (IFN) signature in peripheral blood mononuclear cel
Externí odkaz:
https://doaj.org/article/cdeb1f0ee36e471f9716c22fe45937ce
TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Autor:
Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer, Katrin Paeschke
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets against severe acute respir
Externí odkaz:
https://doaj.org/article/482e5826db224a729a72cbb3f46861e9
Autor:
Alessio De Magis, Michaela Limmer, Venkat Mudiyam, David Monchaud, Stefan Juranek, Katrin Paeschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Senescence has two roles in oncology: it is known as a potent tumor-suppressive mechanism, which also supports tissue regeneration and repair, it is also known to contribute to reduced patient resilience, which might lead to cancer recurrenc
Externí odkaz:
https://doaj.org/article/6587942841c340699a216b4c762cb0e3
Autor:
Fabian Hersperger, Tim Meyring, Pia Weber, Chintan Chhatbar, Gianni Monaco, Marc S Dionne, Katrin Paeschke, Marco Prinz, Olaf Groß, Anne-Kathrin Classen, Katrin Kierdorf
Publikováno v:
eLife, Vol 12 (2024)
Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades, conserved from invertebrates to mammals, ensure reestablishment of homeostasis and tissue re
Externí odkaz:
https://doaj.org/article/73eb2793298442e9a0c9ec15b7293262
Autor:
Kathrin Olschok, Bianca Altenburg, Marcelo A. S. de Toledo, Angela Maurer, Anne Abels, Fabian Beier, Deniz Gezer, Susanne Isfort, Katrin Paeschke, Tim H. Brümmendorf, Martin Zenke, Nicolas Chatain, Steffen Koschmieder
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Imetelstat shows activity in patients with myeloproliferative neoplasms, including primary myelofibrosis (PMF) and essential thrombocythemia. Here, we describe a case of prolonged disease stabilization by imetelstat treatment of a high-risk PMF patie
Externí odkaz:
https://doaj.org/article/22f86771bc0443b6890a712facd8c199
Autor:
Vanessa Borges Pires, Nina Lohner, Tina Wagner, Carolin B. Wagner, Maya Wilkens, Mona Hajikazemi, Katrin Paeschke, Falk Butter, Brian Luke
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112077- (2023)
Summary: At critically short telomeres, stabilized TERRA RNA-DNA hybrids drive homology-directed repair (HDR) to delay replicative senescence. However, even at long- and intermediate-length telomeres, not subject to HDR, transient TERRA RNA-DNA hybri
Externí odkaz:
https://doaj.org/article/9324f7a21b5344ca97c728a2a0a845d6
Autor:
Hanna K. Zieger, Leonie Weinhold, Axel Schmidt, Manuel Holtgrewe, Stefan A. Juranek, Anna Siewert, Annika B. Scheer, Frederic Thieme, Elisabeth Mangold, Nina Ishorst, Fabian U. Brand, Julia Welzenbach, Dieter Beule, Katrin Paeschke, Peter M. Krawitz, Kerstin U. Ludwig
Publikováno v:
HGG Advances, Vol 4, Iss 1, Pp 100166- (2023)
Summary: Non-syndromic cleft lip with/without cleft palate (nsCL/P) is a highly heritable facial disorder. To date, systematic investigations of the contribution of rare variants in non-coding regions to nsCL/P etiology are sparse. Here, we re-analyz
Externí odkaz:
https://doaj.org/article/b61b5dc4116e41ea98f08ed8d964fc18
Autor:
Satyaprakash Pandey, Mona Hajikazemi, Theresa Zacheja, Stephanie Schalbetter, Jonathan Baxter, Victor Guryev, Andreas Hofmann, Dieter W. Heermann, Stefan A. Juranek, Katrin Paeschke
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background The main function of telomerase is at the telomeres but under adverse conditions telomerase can bind to internal regions causing deleterious effects as observed in cancer cells. Results By mapping the global occupancy of the catal
Externí odkaz:
https://doaj.org/article/49015b42ea7c44bda95a827b3a9a2668
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Nucleic acids can fold into non-canonical secondary structures named G-quadruplexes (G4s), which consist of guanine-rich sequences stacked into guanine tetrads stabilized by Hoogsteen hydrogen bonding, π-π interactions, and mono
Externí odkaz:
https://doaj.org/article/434443b8e28f4375a881de111208c1f0
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
Abstract DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This structure is called a G-quadruplex (
Externí odkaz:
https://doaj.org/article/647ef10326ef4a228aa7bfc2157bdad1