Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts

Autor: Nandini, Asokan, Stephan, Daetwyler, Stefanie N, Bernas, Christopher, Schmied, Steffen, Vogler, Katrin, Lambert, Manja, Wobus, Martin, Wermke, Gerd, Kempermann, Jan, Huisken, Michael, Brand, Martin, Bornhäuser

Publikováno v: Scientific reports 10(1), 13254 (2020). doi:10.1038/s41598-020-69956-2
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

Understanding mechanisms mediating tumor metastasis is crucial for diagnostic and therapeutic targeting. Here, we take advantage of a transparent embryonic zebrafish xenograft model (eZXM) to visualize and track metastatic cells in real time using se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fd93745af817e473f18ff75ac56332b3

Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells

Autor: Katrin Lambert, Elham Pishali Bejestani, Malte von Bonin, Michael Brand, Dimitra Alexopoulou, Martin Kräter, Andreas Dahl, Friedrich Stölzel, Martin Stöter, Jens Friedrichs, Guruchandar Arulmozhivarman, Manja Wobus, Nona Shayegi, Marc Bickle, Jochen Hampe, Martin Bornhäuser, Katrin Müller

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

The identification of small molecules that either increase the number and/or enhance the activity of human hematopoietic stem and progenitor cells (hHSPCs) during ex vivo expansion remains challenging. We used an unbiased in vivo chemical screen in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15f2bc3562de8ee8b54d72a12c4fb2c