Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Katrin, Fischer"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Intracellular bacteria produce antigens, which serve as potent activators of γδ T cells. Phosphoantigens are presented via a complex of butyrophilins (BTN) to signal infection to human Vγ9+Vδ2+ T cells. Here, we established an in vitro s
Externí odkaz:
https://doaj.org/article/2ebb5ff07930467bb3fcd1c7baaebc6e
Autor:
Timo N. Kohler, Joachim De Jonghe, Anna L. Ellermann, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Antonia Weberling, Clara Munger, Katrin Fischer, Carla Mulas, Alex Winkel, Connor Ross, Sophie Bergmann, Kristian Franze, Kevin Chalut, Jennifer Nichols, Thorsten E. Boroviak, Florian Hollfelder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs will provide insight into mechanisms underlying mammalian pre-imp
Externí odkaz:
https://doaj.org/article/19d37a4e6ae24ca8b14f83a6a064a669
Autor:
Juan Carlos Yam-Puc, Zhaleh Hosseini, Emily C. Horner, Pehuén Pereyra Gerber, Nonantzin Beristain-Covarrubias, Robert Hughes, Aleksei Lulla, Maria Rust, Rebecca Boston, Magda Ali, Katrin Fischer, Edward Simmons-Rosello, Martin O’Reilly, Harry Robson, Lucy H. Booth, Lakmini Kahanawita, Andrea Correa-Noguera, David Favara, Lourdes Ceron-Gutierrez, Baerbel Keller, Andrew Craxton, Georgina S. F. Anderson, Xiao-Ming Sun, Anne Elmer, Caroline Saunders, Areti Bermperi, Sherly Jose, Nathalie Kingston, Thomas E. Mulroney, Lucia P. G. Piñon, CITIID-NIHR COVID−19 BioResource Collaboration, Michael A. Chapman, Sofia Grigoriadou, Marion MacFarlane, Anne E. Willis, Kiran R. Patil, Sarah Spencer, Emily Staples, Klaus Warnatz, Matthew S. Buckland, Florian Hollfelder, Marko Hyvönen, Rainer Döffinger, Christine Parkinson, Sara Lear, Nicholas J. Matheson, James E. D. Thaventhiran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here, we investigate whet
Externí odkaz:
https://doaj.org/article/6ba7520f8a864e5db48cb0eaab277223
Autor:
Ester Colarusso, Marianna Potenza, Gianluigi Lauro, Maria Giovanna Chini, Valentina Sepe, Angela Zampella, Katrin Fischer, Robert K. Hofstetter, Oliver Werz, Giuseppe Bifulco
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 5, Iss , Pp 100046- (2022)
Here we report the application of a multi-disciplinary protocol for investigating thiazolidin-4-one-based compounds as new promising anti-inflammatory agents interfering with the eicosanoid biosynthesis pathways. The workflow foresaw the generation o
Externí odkaz:
https://doaj.org/article/28d5a88b8f9f47c48c0a6c7656ee3ed4
Autor:
Anastasia Georgiadi, Valeria Lopez-Salazar, Rabih El- Merahbi, Rhoda Anane Karikari, Xiaochuan Ma, André Mourão, Katarina Klepac, Lea Bühler, Ana Jimena Alfaro, Isabell Kaczmarek, Adam Linford, Madeleen Bosma, Olga Shilkova, Olli Ritvos, Nobuhiro Nakamura, Shigehisa Hirose, Maximilian Lassi, Raffaele Teperino, Juliano Machado, Marcel Scheideler, Arne Dietrich, Arie Geerlof, Annette Feuchtinger, Andreas Blutke, Katrin Fischer, Timo Dirk Müller, Katharina Kessler, Torsten Schöneberg, Doreen Thor, Silke Hornemann, Michael Kruse, Peter Nawroth, Olga Pivovarova-Ramich, Andreas Friedrich Hermann Pfeiffer, Michael Sattler, Matthias Blüher, Stephan Herzig
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
The soluble bioactive form of the transmembrane protein fibronectin type III domain containing 4 (sFNDC4) has anti-inflammatory effects and improves insulin sensitivity. Here the authors show that liver derived sFNDC4 signals through adipose tissue G
Externí odkaz:
https://doaj.org/article/899459e9671c4eeca6889de131d50098
Autor:
Simon Höllerer, Laetitia Papaxanthos, Anja Cathrin Gumpinger, Katrin Fischer, Christian Beisel, Karsten Borgwardt, Yaakov Benenson, Markus Jeschek
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Current methods to generate sequence-function data at large scale are either technically complex or limited to specific applications. Here the authors introduce DNA-based phenotypic recording to overcome these limitations and enable deep learning for
Externí odkaz:
https://doaj.org/article/5cdab11544394bd78e7fc3880bbaa8e2
Autor:
Katrin Fischer, Anna Fenzl, Dianxin Liu, Kenneth A. Dyar, Maximilian Kleinert, Markus Brielmeier, Christoffer Clemmensen, Anna Fedl, Brian Finan, Andre Gessner, Martin Jastroch, Jianfeng Huang, Susanne Keipert, Martin Klingenspor, Jens C. Brüning, Manfred Kneilling, Florian C. Maier, Ahmed E. Othman, Bernd J. Pichler, Ines Pramme-Steinwachs, Stephan Sachs, Angelika Scheideler, Wolfgang M. Thaiss, Henriette Uhlenhaut, Siegfried Ussar, Stephen C. Woods, Julia Zorn, Kerstin Stemmer, Sheila Collins, Maria Diaz-Meco, Jorge Moscat, Matthias H. Tschöp, Timo D. Müller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates
Externí odkaz:
https://doaj.org/article/f38460b423054ee680f7224c62a860c9
Autor:
Ekaterini Platanitis, Duygu Demiroz, Anja Schneller, Katrin Fischer, Christophe Capelle, Markus Hartl, Thomas Gossenreiter, Mathias Müller, Maria Novatchkova, Thomas Decker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
A rapid cellular response to interferons (IFNs) is critical for establishing antimicrobial immunity, but how cells switch from from homeostasis to IFN signaling is not fully understood. Here, the authors provide evidence that IFNs induce gene express
Externí odkaz:
https://doaj.org/article/8672899899844ee1b41b987824ab10f8
Autor:
Regina Kunz, David Y. von Allmen, Renato Marelli, Ulrike Hoffmann-Richter, Joerg Jeger, Ralph Mager, Etienne Colomb, Heinz J. Schaad, Monica Bachmann, Nicole Vogel, Jason W. Busse, Martin Eichhorn, Oskar Bänziger, Thomas Zumbrunn, Wout E. L. de Boer, Katrin Fischer
Publikováno v:
BMC Psychiatry, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Expert psychiatrists conducting work disability evaluations often disagree on work capacity (WC) when assessing the same patient. More structured and standardised evaluations focusing on function could improve agreement. The RELY
Externí odkaz:
https://doaj.org/article/b147a878e83e405e8883d8bf22158616
Autor:
Sigrid Jall, Brian Finan, Gustav Collden, Katrin Fischer, Xinzhong Dong, Matthias H. Tschöp, Timo D. Müller, Christoffer Clemmensen
Publikováno v:
Molecular Metabolism, Vol 23, Iss , Pp 75-81 (2019)
Objective: The contribution of brown adipose tissue (BAT) to adult human metabolic control is a topic of ongoing investigation. In context, understanding the cellular events leading to BAT uncoupling, heat production, and energy expenditure is antici
Externí odkaz:
https://doaj.org/article/d018742e0c064bc5990c9502af8d06ee