Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Katrien Willegems"'
Autor:
Katrien Willegems, Jodene Eldstrom, Efthimios Kyriakis, Fariba Ataei, Harutyun Sahakyan, Ying Dou, Sophia Russo, Filip Van Petegem, David Fedida
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
KCNQ1 channels are active in heart, brain and gut. Functional loss causes epilepsy and sudden arrhythmic death. Here, authors describe a key activator drug binding site, explaining isoform and drug selectivity, and point the way for new drug design.
Externí odkaz:
https://doaj.org/article/36808af22e5f44a7951153674f707712
Autor:
Eveline Wijckmans, Mieke Nys, Sarah Debaveye, Marijke Brams, Els Pardon, Katrien Willegems, Daniel Bertrand, Jan Steyaert, Rouslan Efremov, Chris Ulens
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151183 (2016)
Cys-loop receptors are membrane spanning ligand-gated ion channels involved in fast excitatory and inhibitory neurotransmission. Three-dimensional structures of these ion channels, determined by X-ray crystallography or electron microscopy, have reve
Externí odkaz:
https://doaj.org/article/cbfe1b4f12f54c099efaa6a7d02c1f0d
Autor:
Efthymios Kyriakis, Jodene Eldstrom, Katrien Willegems, Fariba Ataei, Harutyun Sahakyan, Ying Dou, Sophia Russo, Filip Van Petegem, David Fedida
Publikováno v:
Biophysical Journal. 122:21a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef3e0bba13378a5bb427077acbd6371a
https://doi.org/10.1016/j.bpj.2022.11.341
https://doi.org/10.1016/j.bpj.2022.11.341
Autor:
Rouslan G. Efremov, Katrien Willegems
Understanding gating principles of ion channels at high resolution is of great importance. Here we investigate the conformational transition from closed to open state in ryanodine receptor 1 (RyR1) reconstituted into lipid nanodiscs. RyR1 is a homote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a21453c6f60aea0d8516236ee168d1
https://hdl.handle.net/20.500.14017/68d0eac2-1ceb-411e-a560-8fa2b00d5a1a
https://hdl.handle.net/20.500.14017/68d0eac2-1ceb-411e-a560-8fa2b00d5a1a
Autor:
Katrien, Willegems, Rouslan G, Efremov
Publikováno v:
Advances in experimental medicine and biology. 981
Ryanodine receptors (RyRs) are large intracellular calcium release channels that play a crucial role in coupling excitation to contraction in both cardiac and skeletal muscle cells. In addition, they are expressed in other cell types where their func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3a16af4e448d18d3b9a4291a74baec5
https://pubmed.ncbi.nlm.nih.gov/29594862
https://pubmed.ncbi.nlm.nih.gov/29594862
Autor:
Els Pardon, Sarah Debaveye, Marijke Brams, Rouslan G. Efremov, Daniel Bertrand, Mieke Nys, Jan Steyaert, Chris Ulens, Katrien Willegems, Eveline Wijckmans
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151183 (2016)
PLoS ONE
PLoS ONE
Cys-loop receptors are membrane spanning ligand-gated ion channels involved in fast excitatory and inhibitory neurotransmission. Three-dimensional structures of these ion channels, determined by X-ray crystallography or electron microscopy, have reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b931ddf9995e95c1ecf5bdc1f5fd6814
https://doi.org/10.1371/journal.pone.0151183
https://doi.org/10.1371/journal.pone.0151183