Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts

Autor: Debora Collotta, Massimo Collino, Katrien H.J. Gaens, Raffaella Mastrocola, Kristiaan Wouters, Claudio Medana, Alessia Sofia Cento, Federica Dal Bello, Casper G. Schalkwijk, Manuela Aragno

Publikováno v: Free Radical Biology and Medicine, 169, 425-435. Elsevier Science

High plasma levels of the sphingolipid intermediates ceramide (Cer) and sphingosine-1-phosphate (S1P) are suggested to be involved in the development of insulin resistance (IR). Recent evidence indicates that advanced glycation endproducts (AGEs) can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e87d9efce8ae908986be86381dfd7d
http://hdl.handle.net/2318/1789498

Genetic deletion of RAGE in Dbdb mice interferes with AGEs receptors and detoxifying systems in liver

Autor: Debora Collotta, Manuela Aragno, Katrien H.J. Gaens, Raffaella Mastrocola, Margee Robertus, Massimo Collino, Alessia Sofia Cento, Fausto Chiazza, Jean L.J.M. Scheijen, Casper G. Schalkwijk, Federica Barutta, Kristiaan Wouters

Advanced glycation end products (AGEs) are toxic compounds involved in the development of diabetes complications and the onset of insulin resistance in obesity. In particular, AGEs are preferentially trapped by adipose tissue through the binding with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75428290481269923cca44f3634d00e3
https://hdl.handle.net/2318/1889881

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Autor: Johan W. E. Jocken, Gijs H. Goossens, Katrien H.J. Gaens, Mitchell Bijnen, Casper G. Schalkwijk, Kenneth Verboven, Kristiaan Wouters, Coen D.A. Stehouwer, Suzan Wetzels, Ellen E. Blaak, Dominique Hansen

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports, 8:4677. Nature Publishing Group

Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR). We investigated whether AT phenotype in di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8818359c97100575834448424f412c47
https://pubmed.ncbi.nlm.nih.gov/29549282

Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance

Autor: Marleen M.J. van Greevenbroek, Marc A. M. J. van Zandvoort, Coen D.A. Stehouwer, Jan Greve, Hans W.M. Niessen, Carla J.H. van der Kallen, Casper G. Schalkwijk, Gijs H. Goossens, Sander S. Rensen, Ellen E. Blaak, Petra M.G. Niessen, Katrien H.J. Gaens, Wim A. Buurman, Angelika Bierhaus

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology, 34(6), 1199-1208. Lippincott Williams and Wilkins
Gaens, K H J, Goossens, G H, Niessen, P M, van Greevenbroek, M M, van der Kallen, C J H, Niessen, H W M, Rensen, S S, Buurman, W A, Greve, J W M, Blaak, E E, van Zandvoort, M A, Bierhaus, A, Stehouwer, C D A & Schalkwijk, C G 2014, ' Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 6, pp. 1199-1208 . https://doi.org/10.1161/ATVBAHA.113.302281
Arteriosclerosis Thrombosis and Vascular Biology, 34(6), 1199-1208. LIPPINCOTT WILLIAMS & WILKINS

Objective— Dysregulation of inflammatory adipokines by the adipose tissue plays an important role in obesity-associated insulin resistance. Pathways leading to this dysregulation remain largely unknown. We hypothesized that the receptor for advance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d93065d98ca35968cefcb8cea56ab8
https://cris.maastrichtuniversity.nl/en/publications/d72cf629-f836-43c5-839f-758c2304fbf3

Receptor for Advanced Glycation End Product Polymorphisms and Type 2 Diabetes

Autor: Edith J. M. Feskens, Casper G. Schalkwijk, Carla J.H. van der Kallen, Coen D.A. Stehouwer, Katrien H.J. Gaens, Marleen M.J. van Greevenbroek

Publikováno v: Annals of the New York Academy of Sciences. 1126:162-165

Genetic variation in the receptor for advanced glycation end products (RAGE) gene may alter the expression and function of RAGE and affect disease development and outcome. We investigated whether single nucleotide polymorphisms (SNPs) in RAGE were as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5993085dccbdb6e411bf174a8384b30b
https://doi.org/10.1196/annals.1433.013