Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Katrien Brak"'
Autor:
Lydia C. Wolfe, W. Stacy Bremner, Katrien Brak, Witold Subotkowski, Andrew C. Stevens, Heumann Lars, Andrei Chtchemelinine, Tiago Vieira, Chia-Yun Yu, James A. Kerschen, Boran Xu, Angela M. Brown
Publikováno v:
Organic Process Research & Development. 26:754-763
Autor:
Katrien Brak, Eric N. Jacobsen
Publikováno v:
Angewandte Chemie. 125:558-588
Publikováno v:
Journal of the American Chemical Society. 130:6404-6410
Cruzain is the major cysteine protease of Trypanosoma cruzi, which is the causative agent of Chagas disease and is a promising target for the development of new chemotherapy. With the goal of developing potent nonpeptidic inhibitors of cruzain, the s
Publikováno v:
Brain Research, 1201, 93-99. Elsevier
In the schedule-induced polydipsia model, hungry rats receiving a food pellet every minute will display excessive drinking behaviour (compulsive behaviour). We aimed 1) to evaluate if electrical stimulation in the nucleus accumbens (N ACC), the medio
Autor:
Eric N. Jacobsen, Katrien Brak
Publikováno v:
ChemInform. 44
Charged intermediates and reagents are ubiquitous in organic transformations. The interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has emerged as a powerful strategy for catalytic, enantioselective synthesi
Autor:
Eric N. Jacobsen, Katrien Brak
Charged intermediates and reagents are ubiquitous in organic transformations. The interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has emerged as a powerful strategy for catalytic, enantioselective synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cc9c767c05db76d35d5ac89da16054
https://europepmc.org/articles/PMC4284951/
https://europepmc.org/articles/PMC4284951/
Autor:
Jonathan A. Ellman, Katrien Brak
Publikováno v:
ChemInform. 41
The target compound is obtained in total 6 or 5 steps by using the reaction with the boron complex (III) or a Grignard reagent (X), respectively.
Autor:
Jonathan A. Ellman, Katrien Brak
Publikováno v:
ChemInform. 41
The MIDA boronates are efficient coupling partners which allow formation of α-branched amines in good yields with excellent enantioselectivity.
Autor:
James H. McKerrow, Jonathan A. Ellman, Moumita Debnath, Iain D. Kerr, Patricia S. Doyle, Linda S. Brinen, Kenny K. H. Ang, Kimberly T. Barrett, Katrien Brak, Juan C. Engel, Nobuhiro Fuchi
Publikováno v:
Journal of medicinal chemistry. 53(4)
A century after discovering that the Trypanosoma cruzi parasite is the etiological agent of Chagas disease, treatment is still plagued by limited efficacy, toxicity, and the emergence of drug resistance. The development of inhibitors of the major T.
Autor:
Jonathan A. Ellman, Katrien Brak
Publikováno v:
ChemInform. 40
The first Rh(I)-catalyzed addition of alkenylboron reagents to imines is described. The Rh(I)-catalyzed addition of potassium alkenyltrifluoroborate salts to both aromatic and aliphatic N-tert-butanesulfinyl aldimines proceeds in good yields (up to 9