Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Katrien, Vermeiren"'
Publikováno v:
Frontiers in Pharmacology. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73175ab03e6f92e420d4ef104f3f7f2
https://doi.org/10.3389/conf.fphar.2017.62.00005
https://doi.org/10.3389/conf.fphar.2017.62.00005
Autor:
Annick Scholliers, Pascale Dehertogh, Pierre Raboisson, Oliver Lenz, Jan Martin Berke, Els Fransen, Gregory Fanning, Thierry Verbinnen, Jimmy Lindberg, Tse-I Lin, Susan Storm, Herman de Kock, Tania Ivens, Michael Edlund, Leen Vijgen, Lotta Vrang, Katrien Vermeiren, Kenneth Simmen, Maxwell D. Cummings
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:1878-1887
TMC435 is a small-molecule inhibitor of the NS3/4A serine protease of hepatitis C virus (HCV) currently in phase 2 development. The in vitro resistance profile of TMC435 was characterized by selection experiments with HCV genotype 1 replicon cells an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21ebb749bf0b2eae7d32c688bb91198
https://doi.org/10.1128/aac.01452-09
https://doi.org/10.1128/aac.01452-09
Autor:
Geneviève Vandercruyssen, Origène Nyanguile, Leen Vijgen, Frederik Pauwels, Pascale Dehertogh, Koen Dockx, Hendrik L. De Bondt, Wendy Mostmans, Benoit Devogelaere, Gregory Fanning, Vendeville Sandrine Marie Hele, Pierre Raboisson, Oliver Lenz, Frederic Delouvroy, Ann Vos, Koen Vandyck, Katrien Vermeiren, Erna Cleiren, Walter Van den Broeck, Jan Martin Berke, Kenneth Simmen, Maxwell D. Cummings
Publikováno v:
Journal of Virology. 84:2923-2934
The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7fe42c112a586f3f503effe1181796
https://doi.org/10.1128/jvi.01980-09
https://doi.org/10.1128/jvi.01980-09
Autor:
David McGowan, Origène Nyanguile, Maxwell D. Cummings, Sandrine Vendeville, Koen Vandyck, Walter Van den Broeck, Carlo W. Boutton, Hendrik De Bondt, Ludo Quirynen, Katie Amssoms, Jean-François Bonfanti, Stefaan Last, Klara Rombauts, Abdellah Tahri, Lili Hu, Frédéric Delouvroy, Katrien Vermeiren, Geneviève Vandercruyssen, Liesbet Van der Helm, Erna Cleiren, Wendy Mostmans, Pedro Lory, Geert Pille, Kristof Van Emelen, Gregory Fanning, Frederik Pauwels, Tse-I Lin, Kenneth Simmen, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2492-2496
Optimization through parallel synthesis of a novel series of hepatitis C virus (HCV) NS5B polymerase inhibitors led to the identification of ( R )-11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-10-(6-methylpyridine-2-carbonyl)-2,3,4,5,10,11-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8521efff0fc4c0c065284cf8f74ff171
https://doi.org/10.1016/j.bmcl.2009.03.035
https://doi.org/10.1016/j.bmcl.2009.03.035
Autor:
Pierre Raboisson, Tse-I Lin, Bertil Samuelsson, Frederic Delouvroy, Katrien Vermeiren, Lotta Vrang, Oliver Lenz, Kenneth Simmen, Piet Wigerinck, Michael Edlund, Annick Scholliers, Thierry Verbinnen, Herman de Kock, Åsa Rosenquist, Gregory Fanning
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:1377-1385
The hepatitis C virus (HCV) NS3/4A serine protease has been explored as a target for the inhibition of viral replication in preclinical models and in HCV-infected patients. TMC435350 is a highly specific and potent inhibitor of NS3/4A protease select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47c0107cd6e60ff3a55647377fe4721
https://doi.org/10.1128/aac.01058-08
https://doi.org/10.1128/aac.01058-08
Autor:
Frederic Delouvroy, Katrien Vermeiren, Dominique Louis Nestor Ghislain Surleraux, Sarvajit Chakravarty, Annick Scholliers, Pierre Raboisson, Tse-I Lin, Thierry Verbinnen, Kenneth Simmen, Oliver Lenz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1843-1849
Screening of a focused library of TGF beta kinase inhibitors in the cellular HCV replicon model with luciferase read out yielded a number of low micromolar HCV inhibitors. Medicinal chemistry driven optimization resulted in the discovery of 4-[2-(5-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eb3120dae021934f30b785bf78efee
https://doi.org/10.1016/j.bmcl.2007.01.046
https://doi.org/10.1016/j.bmcl.2007.01.046
Autor:
Edwin Yunhao, Gong, Hannah, Kenens, Tania, Ivens, Koen, Dockx, Katrien, Vermeiren, Geneviève, Vandercruyssen, Benoit, Devogelaere, Pedro, Lory, Guenter, Kraus
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1030
The nonstructural protein 5 (NS5) of dengue virus (DENV) plays a central role in the virus replication. It functions as a methyltransferase and an RNA-dependent RNA polymerase. As such, it is a promising target for antiviral drug development. To deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::102b1fafeb5b0bea29532b5574e2e3dc
https://pubmed.ncbi.nlm.nih.gov/23821273
https://pubmed.ncbi.nlm.nih.gov/23821273
Autor:
Katrien Vermeiren, Koen Dockx, Hannah Kenens, Pedro Lory, Guenter Kraus, Tania Ivens, Edwin Yunhao Gong, Geneviève Vandercruyssen, Benoit Devogelaere
Publikováno v:
Antiviral Methods and Protocols ISBN: 9781627034838
The nonstructural protein 5 (NS5) of dengue virus (DENV) plays a central role in the virus replication. It functions as a methyltransferase and an RNA-dependent RNA polymerase. As such, it is a promising target for antiviral drug development. To deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98561143392e4f1d7b4dceeb16575c5c
https://doi.org/10.1007/978-1-62703-484-5_19
https://doi.org/10.1007/978-1-62703-484-5_19
Autor:
Katrien Vermeiren, Erwin Sablon, Bart Claes, Ina Vandenbroucke, Geert Maertens, Alison V. Todd, Samantha Walker, Nicole E. Lima, Geneviève Vandercruyssen, Elisa Mokany, Lit Yeen Tan, Pascale Holemans, Evelien Rondelez, Inky De Baere
Publikováno v:
Cancer Research. 74:1502-1502
Introduction The MAPK/ERK pathway is a complex signaling cascade involved in many cancer types. KRAS and BRAF gene mutations are present in a number of cancers, including colon, lung and pancreas, and identification of mutations in these genes is of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8991ca4b0f6b75e50d88e710b31918f
https://doi.org/10.1158/1538-7445.am2014-1502
https://doi.org/10.1158/1538-7445.am2014-1502