Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Katrien, De Bock"'
Autor:
Christine Germeys, Tijs Vandoorne, Kristofer Davie, Suresh Poovathingal, Kara Heeren, Wendy Vermeire, FatemehArefeh Nami, Matthieu Moisse, Annelies Quaegebeur, Annerieke Sierksma, Laura Rué, Adrià Sicart, Caroline Eykens, Lenja De Cock, Bart De Strooper, Peter Carmeliet, Philip Van Damme, Katrien De Bock, Ludo Van Den Bosch
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114719- (2024)
Summary: Neuroinflammation and dysregulated energy metabolism are linked to motor neuron degeneration in amyotrophic lateral sclerosis (ALS). The egl-9 family hypoxia-inducible factor (EGLN) enzymes, also known as prolyl hydroxylase domain (PHD) enzy
Externí odkaz:
https://doaj.org/article/f5ca645adeef4451984ced27f8885014
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101923- (2024)
Objectives: We have previously shown that lactate is an essential metabolite for macrophage polarisation during ischemia-induced muscle regeneration. Recent in vitro work has implicated histone lactylation, a direct derivative of lactate, in macropha
Externí odkaz:
https://doaj.org/article/287e519043c34a03a1f37341da88e588
Autor:
Andrés A. Urrutia, Claudia Mesa-Ciller, Andrea Guajardo-Grence, H. Furkan Alkan, Inés Soro-Arnáiz, Anke Vandekeere, Ana Margarida Ferreira Campos, Sebastian Igelmann, Lucía Fernández-Arroyo, Gianmarco Rinaldi, Doriane Lorendeau, Katrien De Bock, Sarah-Maria Fendt, Julián Aragonés
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114103- (2024)
Summary: Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. However, lower glycolysis is compromised in human clear cell renal cell carcinomas, in which HIF1α acts as a tumor suppressor by inhibiting
Externí odkaz:
https://doaj.org/article/df60877c819f4259a9847dd08cbb7f8b
Autor:
Jonas Hanimann, Daniel P. Fitze, Tobias Götschi, Melanie Gloor, Eling D. de Bruin, Katrien de Bock, Reto Sutter, Jörg Spörri
Publikováno v:
Current Issues in Sport Science, Vol 9, Iss 2 (2024)
Introduction Patellar tendinopathy is frequent in adolescent athletes and particularly accentuated in competitive alpine skiers (Fröhlich et al., 2020). Tendinopathies are characterized by long disease histories, and whether they can be healed co
Externí odkaz:
https://doaj.org/article/919d8e0976544a7abe4ee1e23d1e0fc6
Autor:
Gillian Fitzgerald, Guillermo Turiel, Tatiane Gorski, Inés Soro-Arnaiz, Jing Zhang, Nicola C. Casartelli, Evi Masschelein, Nicola A. Maffiuletti, Reto Sutter, Michael Leunig, Jean Farup, Katrien De Bock
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-21 (2023)
Using single nuclei and single cell RNA-seq, 3 FAP cell subpopulations are identified in human skeletal muscle, with an MME+ subset showing increased adipogenic potential under fatty infiltration conditions.
Externí odkaz:
https://doaj.org/article/6235bdf1b70e4784936defbd604d3383
Autor:
Eva Galle, Chee-Wai Wong, Adhideb Ghosh, Thibaut Desgeorges, Kate Melrose, Laura C. Hinte, Daniel Castellano-Castillo, Magdalena Engl, Joao Agostinho de Sousa, Francisco Javier Ruiz-Ojeda, Katrien De Bock, Jonatan R. Ruiz, Ferdinand von Meyenn
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation. Results Given the expected relevance of this modification and current limited
Externí odkaz:
https://doaj.org/article/c9ecdc1a92de4e0786206a8879e43b67
Autor:
Marc Schwab, Ignazio de Trizio, Moheb Ghobrial, Jau-Ye Shiu, Oguzkan Sürücü, Francesco Girolamo, Mariella Errede, Murat Yilmaz, Johannes Haybaeck, Alessandro Moiraghi, Philippe P. Monnier, Sean E. Lawler, Jeffrey P. Greenfield, Ivan Radovanovic, Karl Frei, Ralph Schlapbach, Viola Vogel, Daniela Virgintino, Katrien De Bock, Thomas Wälchli
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Glioblastomas are among the deadliest human cancers and are highly vascularized. Angiogenesis is dynamic during brain development, almost quiescent in the adult brain but reactivated in vascular-dependent CNS pathologies, including brain tumors. The
Externí odkaz:
https://doaj.org/article/3c686c5575aa4c10bf181a463b9ada86
Autor:
Sara Blocquiaux, Monique Ramaekers, Ruud Van Thienen, Henri Nielens, Christophe Delecluse, Katrien De Bock, Martine Thomis
Publikováno v:
JCSM Rapid Communications, Vol 5, Iss 1, Pp 10-32 (2022)
Abstract Background The interaction between the muscle methylome and transcriptome is understudied during ageing and periods of resistance training in young, but especially older adults. More information is needed on the role of retained methylome tr
Externí odkaz:
https://doaj.org/article/1b3d1cb6cae847499b9b2f71d49a77c1
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101615- (2022)
Objective: Exercise enhances the sensitivity of mammalian target of rapamycin complex 1 (mTORC1) to amino acids, in particular leucine. How long this enhanced sensitivity lasts, and which mechanisms control enhanced leucine-mediated mTORC1 activation
Externí odkaz:
https://doaj.org/article/28867b463d394bc38e610af6e50a2770
Autor:
Ariane C. Scheuren, Gommaar D'Hulst, Gisela A. Kuhn, Evi Masschelein, Esther Wehrle, Katrien De Bock, Ralph Müller
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 4, Pp 1121-1140 (2020)
Abstract Background Frailty is a geriatric syndrome characterized by increased susceptibility to adverse health outcomes. One major determinant thereof is the gradual weakening of the musculoskeletal system and the associated osteosarcopenia. To impr
Externí odkaz:
https://doaj.org/article/a99a8a388d83469c8da426eb0e6d217a