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pro vyhledávání: '"Katrice D. Long"'
Autor:
Katrice D. Long, Jessica A. Burket, Brooke L. Gaskins, John Mastropaolo, Richard B. Rosse, Stephen I. Deutsch
Publikováno v:
European Neuropsychopharmacology. 18:565-568
Twenty-four hours after mice are exposed to a single session of forced swimming in cold water, the ability of MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist, to antagonize electrically precipitated seizures is reduced. Conceivably, t
Publikováno v:
Clinical Neuropharmacology. 31:104-119
Chromatin remodeling is recognized as a major regulator of gene expression that can be influenced by inhibition of epigenetic mechanisms that result in stable, heritable, covalent modifications of histone proteins and their associated DNA. Epigenetic
Autor:
Nina R. Schooler, Barbara L. Schwartz, John Mastropaolo, Brooke L. Gaskins, Stephen I. Deutsch, Richard B. Rosse, Katrice D. Long
Publikováno v:
European Neuropsychopharmacology. 18:147-151
The regionally selective reduction of expression of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) in schizophrenia underlies impaired sensory inhibition, a possible endophenotype of the disorder. This ligand-gated ion channel receptor ha
Publikováno v:
Clinical Neuropharmacology. 29:361-363
Sarcosinemia is a relatively rare autosomal recessive disorder that has a varied phenotypic presentation; rarely, it is associated with neurodevelopmental and neurological abnormalities. Sarcosine is a key intermediate in 1-carbon metabolism, and its
Autor:
Richard B. Rosse, Ronit Weizman, Katrice D. Long, S.I. Deutsch, Judy Eller, Yousef Tizabi, John Mastropaolo
Publikováno v:
Contemporary Clinical Neuroscience ISBN: 9781588295071
Although the thinking and affective and social disturbances of psychosis and schizophrenia may not be easily modeled, if at all, in infrahuman species, animal models can clarify genetic and developmental lesions leading to disruption of some of the k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18e9070171b2081c4f88bd98d31c99da
https://doi.org/10.1007/978-1-59745-058-4_10
https://doi.org/10.1007/978-1-59745-058-4_10
Autor:
Marta M. Wegorzewska, Kristyn A. Krolikowski, Joseph H. Neale, Ana C. Monteiro, Jia Zhou, Katrice D. Long, Rafal T. Olszewski, Alan P. Kozikowski, Stephen I. Deutsch, John Mastropaolo
Publikováno v:
Biological psychiatry. 63(1)
Background N -methyl-d-aspartate (NMDA) receptor open channel blockers phencyclidine (PCP) and dizocilpine (MK-801) elicit schizophrenia-like symptoms in humans and in animal models. Group II metabotropic glutamate receptor agonists reverse the behav
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 18(4)
Guanosine, a purine nucleotide, promotes the reuptake of l-glutamate by astrocytes; astrocytic reuptake of glutamate is a major mechanism of its synaptic inactivation. The current experiments showed that guanosine reduced the ability of MK-801 (dizoc
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 17(1)
NMDA receptor hypofunction (NRH) has been implicated in the pathophysiology of schizophrenia because of the ability of phencyclidine (PCP), a noncompetitive NMDA receptor antagonist, to precipitate a schizophreniform psychosis. The possible role that
Publikováno v:
Brain research bulletin. 69(6)
Abnormalities of NMDA receptor-mediated neurotransmission are involved in the pathophysiology of schizophrenia, Alzheimer's disease, substance abuse and seizure disorders. The NMDA receptor is implicated in schizophrenia because phencyclidine (PCP),
Publikováno v:
Clinical neuropharmacology. 28(1)
The Lesch-Nyhan syndrome is a devastating sex-linked recessive disorder resulting from almost complete deficiency of the activity of hypoxanthine phosphoribosyltransferase (HPRT). The enzyme deficiency results in an inability to synthesize the nucleo