Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katri Pärna"'
Autor:
Zhen Qiao, Julia Sidorenko, Joana A. Revez, Angli Xue, Xueling Lu, Katri Pärna, Harold Snieder, Lifelines Cohort Study, Peter M. Visscher, Naomi R. Wray, Loic Yengo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Most genetic studies of glucose levels have been done on fasting samples, which can be difficult to obtain. Here, the authors identify 156 genetic loci controlling the physiological variation of glucose levels in healthy non-fasting individuals, demo
Externí odkaz:
https://doaj.org/article/6fde8113956e402caba8686de06ed2d1
Autor:
Katri Pärna, Ilja M. Nolte, Harold Snieder, Krista Fischer, Estonian Biobank Research Team, Davide Marnetto, Luca Pagani
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
One important confounder in genome-wide association studies (GWASs) is population genetic structure, which may generate spurious associations if not properly accounted for. This may ultimately result in a biased polygenic risk score (PRS) prediction,
Externí odkaz:
https://doaj.org/article/7f8647c701ed441996a59382d1c23a2d
Autor:
Davide Marnetto, Katri Pärna, Kristi Läll, Ludovica Molinaro, Francesco Montinaro, Toomas Haller, Mait Metspalu, Reedik Mägi, Krista Fischer, Luca Pagani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Polygenic scores are believed to hold future promise for trait prediction and personalized medicine, but are sensitive to demographic history. Here, Marnetto et al. develop partial polygenic scores supplemented with local ancestry deconvolution which
Externí odkaz:
https://doaj.org/article/f95c60326b1a4da89c378b225bf30d78
Autor:
Bram Peter Prins, Liis Leitsalu, Katri Pärna, Krista Fischer, Andres Metspalu, Toomas Haller, Harold Snieder
Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 5, p 358 (2021)
The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to r
Externí odkaz:
https://doaj.org/article/1219c660f87143e58ff05669f8d30e32
Publikováno v:
Nature Communications. 14
The genetic regulation of post-prandial glucose levels is poorly understood. Here, we characterise the genetic architecture of blood glucose variably measured within 0 and 24 h of fasting in 368,000 European ancestry participants of the UK Biobank. W
Autor:
Zhen Qiao, Julia Sidorenko, Joana A. Revez, Angli Xue, Xueling Lu, Katri Pärna, Harold Snieder, Lifelines Cohort Study, Peter M. Visscher, Naomi R. Wray, Loic Yengo
This upload includes the sample code that was used in the paper "Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose", which has been accepted for publication in Nature Communications. Abstract The genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc6c2c510b7bf2eb154c80dfd16887e
Publikováno v:
Diabetologia, 65, 1364-1374. SPRINGER
Aims/hypothesis Type 2 diabetes mellitus is a major health burden disproportionately affecting those with lower educational attainment (EA). We aimed to obtain causal estimates of the association between EA and type 2 diabetes and to quantify mediati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc40e23047407eb54648193524baacc
https://research.rug.nl/en/publications/aeab3820-3c2f-4707-b55d-be657d3a60ac
https://research.rug.nl/en/publications/aeab3820-3c2f-4707-b55d-be657d3a60ac
Publikováno v:
Genetic Epidemiology
Genetic epidemiology, 44(6), 589-600. Wiley
Genetic epidemiology, 44(6), 589-600. Wiley
As many cases of type 2 diabetes (T2D) are likely to remain undiagnosed, better tools for early detection of high-risk individuals are needed to prevent or postpone the disease. We investigated the value of the doubly weighted genetic risk score (dwG
Autor:
Kristi Läll, Luca Pagani, Davide Marnetto, Francesco Montinaro, Katri Pärna, Krista Fischer, Reedik Mägi, Ludovica Molinaro, Toomas Haller, Mait Metspalu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications, 11(1):1628. Nature Publishing Group
Nature Communications
Nature Communications, 11(1):1628. Nature Publishing Group
Polygenic Scores (PSs) describe the genetic component of an individual’s quantitative phenotype or their susceptibility to diseases with a genetic basis. Currently, PSs rely on population-dependent contributions of many associated alleles, with lim
Autor:
Davide Marnetto, Vasili Pankratov, Mayukh Mondal, Francesco Montinaro, Katri Pärna, Leonardo Vallini, Ludovica Molinaro, Lehti Saag, Liisa Loog, Sara Montagnese, Rodolfo Costa, Mait Metspalu, Anders Eriksson, Luca Pagani
Publikováno v:
Current Biology, 32(6), 1412-1419.e3. CELL PRESS
The contemporary European genetic makeup formed in the last 8,000 years when local Western Hunter-Gatherers (WHGs) mixed with incoming Anatolian Neolithic farmers and Pontic Steppe pastoralists.1–3 This encounter combined genetic variants with dist