G protein-coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling.

Autor: Tóth AD; Institute of Molecular Life Sciences, Centre of Excellence of the Hungarian Academy of Sciences, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary.; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary.; Department of Internal Medicine and Haematology, Semmelweis University, Szentkirályi utca 46, H-1088 Budapest, Hungary., Szalai B; Institute of Molecular Life Sciences, Centre of Excellence of the Hungarian Academy of Sciences, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary.; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary., Kovács OT; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary., Garger D; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary.; Computational Health Center, Helmholtz Munich, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany., Prokop S; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary., Soltész-Katona E; Institute of Molecular Life Sciences, Centre of Excellence of the Hungarian Academy of Sciences, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary., Balla A; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary.; HUN-REN-SE Laboratory of Molecular Physiology, Hungarian Research Network, Tűzoltó utca 37-47, H-1094 Budapest, Hungary., Inoue A; Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578 Japan., Várnai P; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary.; HUN-REN-SE Laboratory of Molecular Physiology, Hungarian Research Network, Tűzoltó utca 37-47, H-1094 Budapest, Hungary., Turu G; Institute of Molecular Life Sciences, Centre of Excellence of the Hungarian Academy of Sciences, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary.; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary., Hunyady L; Institute of Molecular Life Sciences, Centre of Excellence of the Hungarian Academy of Sciences, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary.; Department of Physiology, Faculty of Medicine, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary.

Publikováno v: Science signaling [Sci Signal] 2024 Jun 25; Vol. 17 (842), pp. eadi0934. Date of Electronic Publication: 2024 Jun 25.

Minimal factor XIII activity level to prevent major spontaneous bleeds

Autor: Menegatti, M., Palla, R., Boscarino, M., Bucciarelli, P., Muszbek, L., Katona, E., Makris, M., Peyvandi, F. ^*, Halimeh, S., Lachmann, B., Bidlingmaier, C., Platokouki, H., Pergantou, H., Siboni, S.M., Schutgens, R.E.G., Borhany, M., Fatima, N., Mikovic, D., Saracevic, M., De Moerloose, P., Casini, A., Ozdemir, N., Ay, Y., Mumford, A., Harvey, A., Payne, J., Shapiro, A.D., Williamson, A., Chapin, J., Hsu, F.

Publikováno v: In Journal of Thrombosis and Haemostasis September 2017 15(9):1728-1736

PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.

Autor: Milioto C; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Carcolé M; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Giblin A; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UCL Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK., Coneys R; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Attrebi O; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Ahmed M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK., Harris SS; UK Dementia Research Institute, University College London, London, UK., Lee BI; UK Dementia Research Institute, University College London, London, UK., Yang M; UK Dementia Research Institute, University College London, London, UK., Ellingford RA; UK Dementia Research Institute, University College London, London, UK., Nirujogi RS; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK., Biggs D; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Salomonsson S; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Zanovello M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK., de Oliveira P; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Katona E; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Glaria I; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Research Support Service, Institute of Agrobiotechnology, CSIC-Government of Navarra, Mutilva, Spain., Mikheenko A; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK., Geary B; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK., Udine E; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Vaizoglu D; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Anoar S; UCL Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK., Jotangiya K; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Crowley G; UK Dementia Research Institute, University College London, London, UK., Smeeth DM; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Adams ML; UK Dementia Research Institute, University College London, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Niccoli T; UCL Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK., Rademakers R; VIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., van Blitterswijk M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Devoy A; UK Dementia Research Institute, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Hong S; UK Dementia Research Institute, University College London, London, UK., Partridge L; UCL Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK., Coyne AN; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Fratta P; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, London, UK., Alessi DR; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK., Davies B; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Francis Crick Institute, London, UK., Busche MA; UK Dementia Research Institute, University College London, London, UK., Greensmith L; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, London, UK., Fisher EMC; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK. elizabeth.fisher@ucl.ac.uk.; UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, London, UK. elizabeth.fisher@ucl.ac.uk., Isaacs AM; UK Dementia Research Institute, University College London, London, UK. a.isaacs@ucl.ac.uk.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. a.isaacs@ucl.ac.uk.; UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, London, UK. a.isaacs@ucl.ac.uk.

Publikováno v: Nature neuroscience [Nat Neurosci] 2024 Apr; Vol. 27 (4), pp. 643-655. Date of Electronic Publication: 2024 Feb 29.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.

Autor: Riemenschneider H; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany., Simonetti F; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Ludwig-Maximilians-Universität (LMU) Munich, Graduate School of Systemic Neurosciences (GSN), 81377, Munich, Germany.; Institute of Molecular Physiology, Faculty of Biology, Johannes Gutenberg-Universität (JGU), Hanns-Dieter-Hüsch-Weg 17, 55128, Mainz, Germany., Sheth U; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA., Katona E; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Ludwig-Maximilians-Universität (LMU) Munich, Graduate School of Systemic Neurosciences (GSN), 81377, Munich, Germany., Roth S; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Hutten S; Institute of Molecular Physiology, Faculty of Biology, Johannes Gutenberg-Universität (JGU), Hanns-Dieter-Hüsch-Weg 17, 55128, Mainz, Germany., Farny D; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Michaelsen M; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Nuscher B; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität (LMU) Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Schmidt MK; Center for Neuropathology and Prion Research, University Hospital, LMU Munich, Feodor-Lynen-Str. 23, 81377, Munich, Germany., Flatley A; Monoclonal Antibody Core Facility, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany., Schepers A; Monoclonal Antibody Core Facility, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany., Gruijs da Silva LA; Ludwig-Maximilians-Universität (LMU) Munich, Graduate School of Systemic Neurosciences (GSN), 81377, Munich, Germany.; Institute of Molecular Physiology, Faculty of Biology, Johannes Gutenberg-Universität (JGU), Hanns-Dieter-Hüsch-Weg 17, 55128, Mainz, Germany., Zhou Q; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Klopstock T; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Friedrich Baur Institute at the Department of Neurology, University Hospital, LMU Munich, Ziemssenstr. 1a, 80336, Munich, Germany., Liesz A; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Arzberger T; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Center for Neuropathology and Prion Research, University Hospital, LMU Munich, Feodor-Lynen-Str. 23, 81377, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nußbaumstr. 7, 80336, Munich, Germany., Herms J; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Center for Neuropathology and Prion Research, University Hospital, LMU Munich, Feodor-Lynen-Str. 23, 81377, Munich, Germany., Feederle R; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Monoclonal Antibody Core Facility, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany., Gendron TF; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA., Dormann D; Institute of Molecular Physiology, Faculty of Biology, Johannes Gutenberg-Universität (JGU), Hanns-Dieter-Hüsch-Weg 17, 55128, Mainz, Germany.; Institute of Molecular Biology (IMB), Ackermannweg 4, 55128, Mainz, Germany., Edbauer D; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany. dieter.edbauer@dzne.de.; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany. dieter.edbauer@dzne.de.; Ludwig-Maximilians-Universität (LMU) Munich, Graduate School of Systemic Neurosciences (GSN), 81377, Munich, Germany. dieter.edbauer@dzne.de.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Jul 11; Vol. 11 (1), pp. 112. Date of Electronic Publication: 2023 Jul 11.