Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Katleen Fierens"'
Autor:
Frederik J. R. Rombouts, Richard Alexander, Erna Cleiren, Alex De Groot, Michel Carpentier, Joyce Dijkmans, Katleen Fierens, Stefan Masure, Diederik Moechars, Martina Palomino-Schätzlein, Antonio Pineda-Lucena, Andrés A. Trabanco, Daan Van Glabbeek, Ann Vos, Gary Tresadern
Publikováno v:
ACS Omega, Vol 2, Iss 2, Pp 685-697 (2017)
Externí odkaz:
https://doaj.org/article/b8afeb20f88a4af39591a00477541482
Autor:
Lieven Declercq Pharmacist, Sofie Celen PhD, Joan Lecina PhD, Muneer Ahamed PhD, Thomas Tousseyn Prof, MD, PhD, Diederik Moechars PhD, Jesus Alcazar PhD, Manuela Ariza PhD, Katleen Fierens PhD, Astrid Bottelbergs PhD, Jonas Mariën PhD, Rik Vandenberghe Prof, MD, PhD, Ignacio Jose Andres PhD, Koen Van Laere Prof, MD, PhD, Alfons Verbruggen Prof, PhD, Guy Bormans Prof, PhD
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Early clinical results of two tau tracers, [ 18 F]T808 and [ 18 F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire compara
Externí odkaz:
https://doaj.org/article/614086a8936e4b7ebe4f365af2458065
Autor:
Richard Alexander, Frederik J. R. Rombouts, Daan Van Glabbeek, Michel Carpentier, Alex De Groot, Ann Vos, Gary Tresadern, Martina Palomino-Schätzlein, Joyce Dijkmans, Erna Cleiren, Antonio Pineda-Lucena, Katleen Fierens, Diederik Moechars, Andrés A. Trabanco, Stefan Masure
Publikováno v:
ACS Omega
ACS Omega, Vol 2, Iss 2, Pp 685-697 (2017)
ACS Omega, Vol 2, Iss 2, Pp 685-697 (2017)
An approach to identify β-secretase 1 (BACE1) fragment binders that do not interact with the catalytic aspartate dyad is presented. A ThermoFluor (thermal shift) and a fluorescence resonance energy transfer enzymatic screen on the soluble domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4237a2168d7ccae00124ef14a8244990
https://doi.org/10.1021/acsomega.6b00482
https://doi.org/10.1021/acsomega.6b00482
Autor:
José Ignacio Andrés, Michel Koole, Diederik Moechars, Katleen Fierens, Xavier Langlois, Frederik J. R. Rombouts, Koen Van Laere, Guy Bormans, Lieven Declercq, Jonas Mariën, Rik Vandenberghe, Thomas Tousseyn, Gregor James Macdonald, Wim Vanduffel, Mark E. Schmidt, Alfons Verbruggen
Publikováno v:
Journal of Nuclear Medicine. 58:975-981
In this study, we have synthesized and evaluated 18F-JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant value, 8 nM) and high (≥500×) in vitro selectivity for tau over β-amyloid, in comparison with the benchmark comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51a3f07fa5e0e2c6d4a429d5cae9197
https://doi.org/10.2967/jnumed.116.185199
https://doi.org/10.2967/jnumed.116.185199
Autor:
Mark E. Schmidt, Rhys Salter, Cindy Wintmolders, Nigel Austin, Vladimir Chupakhin, Gregor James Macdonald, Astrid Bottelbergs, Paula te Riele, Lu Chen, Katleen Fierens, Diederik Moechars, Andrés A. Trabanco, José-Ignacio Andrés, José Manuel Alonso, Jonas Mariën, Erna Cleiren, Martinez Lamenca Carolina, Frederik J. R. Rombouts, Manuela Ariza, Leenaerts Joseph Elisabeth, Xavier Langlois, Wei Zhang, Alberto Fontana
Publikováno v:
Journal of Medicinal Chemistry. 60:1272-1291
A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64745ac5243f8ad6a7c10ce535237a1a
https://doi.org/10.1021/acs.jmedchem.6b01173
https://doi.org/10.1021/acs.jmedchem.6b01173
Autor:
Lieven, Declercq, Frederik, Rombouts, Michel, Koole, Katleen, Fierens, Jonas, Mariën, Xavier, Langlois, José Ignacio, Andrés, Mark, Schmidt, Gregor, Macdonald, Diederik, Moechars, Wim, Vanduffel, Thomas, Tousseyn, Rik, Vandenberghe, Koen, Van Laere, Alfons, Verbruggen, Guy, Bormans
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 58(6)
In this study, we have synthesized and evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6cc34f82b482c81287e9cb9fabe2af3c
https://pubmed.ncbi.nlm.nih.gov/28232614
https://pubmed.ncbi.nlm.nih.gov/28232614
Autor:
Steven Van Campenhout, Jan A. Delcour, Christophe M. Courtin, Kurt Gebruers, Emmie Dornez, Katleen Fierens
Publikováno v:
Journal of Cereal Science. 52:516-519
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::525d093f70ba20ebf0ed60de9c04998e
https://doi.org/10.1016/j.jcs.2010.08.004
https://doi.org/10.1016/j.jcs.2010.08.004
Publikováno v:
Enzyme and Microbial Technology. 44:189-195
When grown on arabinoxylan as the sole carbon source, the cereal phytopathogen Fusarium graminearum expresses four xylanases. Cloning and heterologous expression of the corresponding xylanase encoding genes and analysis of general biochemical propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85cfbaaa2ee6dd3483a260bb78b95234
https://doi.org/10.1016/j.enzmictec.2008.12.005
https://doi.org/10.1016/j.enzmictec.2008.12.005
Autor:
Johnny Beaugrand, Jan A. Delcour, Kurt Gebruers, Paul Proost, Boubekeur Nadjemi, Katleen Fierens, Christophe M. Courtin, Hind Mokrane
Publikováno v:
Journal of Cereal Science. 48:203-212
A xylanase inhibitor of the xylanase-inhibiting protein (XIP) type was detected in sorghum (Sorghum bicolor L. Moench) whole meal using Western blot and immunoprobing with polyclonal anti-XIP antibodies. No detectable levels of Triticum aestivum xyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404f2f6a56ff3b829185e0e25b173e1f
https://doi.org/10.1016/j.jcs.2007.09.005
https://doi.org/10.1016/j.jcs.2007.09.005
Autor:
Anja Rabijns, Jan A. Delcour, Gert Raedschelders, Tine M. Bourgois, Guido Volckaert, Sigrid Rombouts, Tim Beliën, Christophe M. Courtin, Katleen Fierens, Steven Van Campenhout, Stefaan Sansen, Dung V. Nguyen
Publikováno v:
Journal of Biotechnology. 130:95-105
The Bacillus subtilis endoxylanase XynA (BSXY) is frequently used to improve the functionality of arabinoxylan-containing material in cereal based industries. The presence of endogenous Triticum aestivum xylanase inhibitors (TAXI-I and TAXI-II) in wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a46f59ef634af3e0e7d6e85b330f676
https://doi.org/10.1016/j.jbiotec.2007.02.011
https://doi.org/10.1016/j.jbiotec.2007.02.011