Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Katleen De Preter"'
Autor:
Lotte Cornelli, Ruben Van Paemel, Maísa R. Ferro dos Santos, Sofie Roelandt, Leen Willems, Jelle Vandersteene, Edward Baert, Liselot M. Mus, Nadine Van Roy, Bram De Wilde, Katleen De Preter
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Pediatric central nervous system tumors remain challenging to diagnose. Imaging approaches do not provide sufficient detail to discriminate between different tumor types, while the histopathological examination of tumor tissue shows high int
Externí odkaz:
https://doaj.org/article/b09b088a6a4a4632a066f2855b72dcb8
Autor:
Noah Bonine, Vittorio Zanzani, Annelies Van Hemelryk, Bavo Vanneste, Christian Zwicker, Tinne Thoné, Sofie Roelandt, Sarah-Lee Bekaert, Jan Koster, Isabelle Janoueix-Lerosey, Cécile Thirant, Stéphane Van Haver, Stephen S. Roberts, Liselot M. Mus, Bram De Wilde, Nadine Van Roy, Celine Everaert, Frank Speleman, Vanessa Vermeirssen, Charlotte L. Scott, Katleen De Preter
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114804- (2024)
Summary: Neuroblastoma, a rare embryonic tumor arising from neural crest development, is responsible for 15% of pediatric cancer-related deaths. Recently, several single-cell transcriptome studies were performed on neuroblastoma patient samples to in
Externí odkaz:
https://doaj.org/article/881e70f45b494476aa7c75fe6611cb10
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract A major challenge in precision oncology is to detect targetable cancer vulnerabilities in individual patients. Modeling high-throughput omics data in biological networks allows identifying key molecules and processes of tumorigenesis. Tradit
Externí odkaz:
https://doaj.org/article/e7e24e09cf2c412a8aa77f52b1b4ce12
Autor:
Stéphane Van Haver, Yujie Fan, Sarah-Lee Bekaert, Celine Everaert, Wouter Van Loocke, Vittorio Zanzani, Joke Deschildre, Inés Fernandez Maestre, Adrianna Amaro, Vanessa Vermeirssen, Katleen De Preter, Ting Zhou, Alex Kentsis, Lorenz Studer, Frank Speleman, Stephen S. Roberts
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108096- (2024)
Summary: Studies defining normal and disrupted human neural crest cell development have been challenging given its early timing and intricacy of development. Consequently, insight into the early disruptive events causing a neural crest related diseas
Externí odkaz:
https://doaj.org/article/7a4a8a6eb06847588402732e66ef624f
Autor:
Bieke Decaesteker, Amber Louwagie, Siebe Loontiens, Fanny De Vloed, Sarah-Lee Bekaert, Juliette Roels, Suzanne Vanhauwaert, Sara De Brouwer, Ellen Sanders, Alla Berezovskaya, Geertrui Denecker, Eva D’haene, Stéphane Van Haver, Wouter Van Loocke, Jo Van Dorpe, David Creytens, Nadine Van Roy, Tim Pieters, Christophe Van Neste, Matthias Fischer, Pieter Van Vlierberghe, Stephen S. Roberts, Johannes Schulte, Sara Ek, Rogier Versteeg, Jan Koster, Johan van Nes, Mark Zimmerman, Katleen De Preter, Frank Speleman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The development of neuroblastoma (NB) is regulated by multiple core transcription factors. Here, SOX11 is identified as a potential epigenetic master regulator upstream of the core regulatory circuitry in adrenergic high-risk neuroblastoma.
Externí odkaz:
https://doaj.org/article/c5e038d1e2b747e4b27f9e8e90add70c
Autor:
Nina U. Gelineau, Astrid van Barneveld, Atia Samim, Lieke Van Zogchel, Nathalie Lak, Michelle L. Tas, Yvette Matser, Annelies M. C. Mavinkurve-Groothuis, Martine van Grotel, Jószef Zsiros, Natasha K. A. van Eijkelenburg, Rutger R. G. Knops, Roelof van Ewijk, Karin P. S. Langenberg, Ronald De Krijger, Laura S. Hiemcke-Jiwa, Ruben Van Paemel, Lotte Cornelli, Katleen De Preter, Bram De Wilde, Ellen Van Der Schoot, Godelieve Tytgat
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Background and aimsSolid tumors account for about 30% of all pediatric cancers. The diagnosis is typically based on histological and molecular analysis of a primary tumor biopsy. Liquid biopsies carry several advantages over conventional tissue biops
Externí odkaz:
https://doaj.org/article/1379e9ffb39d4217ac9e2af4db5290ca
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
The use of immune checkpoint inhibitors (ICIs) continues to transform the therapeutic landscape of non-small cell lung cancer (NSCLC), with these drugs now being evaluated at every stage of the disease. In contrast to these advances, little progress
Externí odkaz:
https://doaj.org/article/f5c82a4c31ba4647923708ecc69d99ac
Autor:
Jill Deleu, Kathleen Schoofs, Anneleen Decock, Kimberly Verniers, Sofie Roelandt, Angie Denolf, Joke Verreth, Bram De Wilde, Tom Van Maerken, Katleen De Preter, Jo Vandesompele
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-14 (2022)
Abstract Background Blood plasma, one of the most studied liquid biopsies, contains various molecules that have biomarker potential for cancer detection, including cell-free DNA (cfDNA) and cell-free RNA (cfRNA). As the vast majority of cell-free nuc
Externí odkaz:
https://doaj.org/article/ef68bffeabae4ba1a11a505e8f590a7c
Autor:
Kathleen Schoofs, Annouck Philippron, Francisco Avila Cobos, Jan Koster, Steve Lefever, Jasper Anckaert, Danny De Looze, Jo Vandesompele, Piet Pattyn, Katleen De Preter
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-12 (2022)
Measurement(s) mRNA Sequencing • MicroRNA Sequencing Technology Type(s) sequencer Sample Characteristic - Organism Homo sapiens Sample Characteristic - Location Belgium
Externí odkaz:
https://doaj.org/article/d7024e6d48cf4b9f8910695c89064ea4
Autor:
Lei Zhai, Anushree Balachandran, Rebecca Larkin, Janith A. Seneviratne, Sylvia A. Chung, Amit Lalwani, Shoma Tsubota, Dominik Beck, Kenji Kadomatsu, Anneleen Beckers, Kaat Durink, Katleen De Preter, Frank Speleman, Michelle Haber, Murray D. Norris, Alexander Swarbrick, Belamy B. Cheung, Glenn M. Marshall, Daniel R. Carter
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15571 (2023)
MYCN amplification occurs in approximately 20–30% of neuroblastoma patients and correlates with poor prognosis. The TH-MYCN transgenic mouse model mimics the development of human high-risk neuroblastoma and provides strong evidence for the oncogeni
Externí odkaz:
https://doaj.org/article/d559d7b12c324b4bb5d46cc7f02c2a1c