Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Katja Zappe"'
Autor:
Katja Zappe, Margit Cichna-Markl
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5082 (2024)
High-resolution melting (HRM) is a cost-efficient tool for targeted DNA methylation analysis. HRM yields the average methylation status across all CpGs in PCR products. Moreover, it provides information on the methylation pattern, e.g., the occurrenc
Externí odkaz:
https://doaj.org/article/86f1970d1ffb4ec49adca7dfe65b65ab
Autor:
Katja Zappe, Katharina Pühringer, Simon Pflug, Daniel Berger, Serge Weis, Sabine Spiegl-Kreinecker, Margit Cichna-Markl
Publikováno v:
Cancers, Vol 15, Iss 24, p 5777 (2023)
The response of glioblastoma (GBM) patients to the alkylating agent temozolomide (TMZ) vitally depends on the expression level of the repair protein O6-methylguanine-DNA methyltransferase (MGMT). Since MGMT is strongly regulated by promoter methylati
Externí odkaz:
https://doaj.org/article/8ff12fa7a50a435d8ab4011be8c1b917
Autor:
Katja Zappe, Katharina Pühringer, Simon Pflug, Daniel Berger, Andreas Böhm, Sabine Spiegl-Kreinecker, Margit Cichna-Markl
Publikováno v:
Cells, Vol 12, Iss 12, p 1639 (2023)
The repair protein O6-methylguanine-DNA methyltransferase (MGMT) is regulated epigenetically, mainly by the methylation of the MGMT promoter. MGMT promoter methylation status has emerged as a prognostic and predictive biomarker for patients with newl
Externí odkaz:
https://doaj.org/article/fec16d93245744e29e2ab9eb740cd1b4
Autor:
Katja Zappe, Antonio Kopic, Alexandra Scheichel, Ann-Katrin Schier, Lukas Emanuel Schmidt, Yasmin Borutzki, Heidi Miedl, Martin Schreiber, Theresa Mendrina, Christine Pirker, Georg Pfeiler, Stefan Hacker, Werner Haslik, Dietmar Pils, Andrea Bileck, Christopher Gerner, Samuel Meier-Menches, Petra Heffeter, Margit Cichna-Markl
Publikováno v:
Cells, Vol 12, Iss 11, p 1462 (2023)
The ABC transporter ABCA7 has been found to be aberrantly expressed in a variety of cancer types, including breast cancer. We searched for specific epigenetic and genetic alterations and alternative splicing variants of ABCA7 in breast cancer and inv
Externí odkaz:
https://doaj.org/article/63047c16006448ee8480b8d570179a49
Autor:
Katja Zappe, Christine Pirker, Heidi Miedl, Martin Schreiber, Petra Heffeter, Georg Pfeiler, Stefan Hacker, Werner Haslik, Sabine Spiegl-Kreinecker, Margit Cichna-Markl
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12527 (2021)
Due to its cost-efficiency, high resolution melting (HRM) analysis plays an important role in genotyping of candidate single nucleotide polymorphisms (SNPs). Studies indicate that HRM analysis is not only suitable for genotyping individual SNPs, but
Externí odkaz:
https://doaj.org/article/99f9b8069d9140af89247b2e53ecf2fe
Autor:
Katja Zappe, Margit Cichna-Markl
Publikováno v:
Cells, Vol 9, Iss 10, p 2281 (2020)
ATP-binding cassette (ABC) transporters play a crucial role in multidrug resistance (MDR) of cancers. They function as efflux pumps, resulting in limited effectiveness or even failure of therapy. Increasing evidence suggests that ABC transporters are
Externí odkaz:
https://doaj.org/article/95d7607f4c2845ff907a7b6f8a629d5b
Autor:
Cichna-Markl, Katja Zappe, Katharina Pühringer, Simon Pflug, Daniel Berger, Andreas Böhm, Sabine Spiegl-Kreinecker, Margit
Publikováno v:
Cells; Volume 12; Issue 12; Pages: 1639
The repair protein O6-methylguanine-DNA methyltransferase (MGMT) is regulated epigenetically, mainly by the methylation of the MGMT promoter. MGMT promoter methylation status has emerged as a prognostic and predictive biomarker for patients with newl
Autor:
Katja Zappe, Nasim Sanadgol, Gert Lubec, Georg Pretsch, Roman Smidak, Jana Lubec, Harald Höger, Margit Cichna‑Markl, Volker Korz
Publikováno v:
Amino Acids. 52:543-553
The aim of the current study was to investigate whether doublecortin (DCX), insulin-like growth factor receptor 1 (IGF-1R) and metabotropic glutamate receptor 5 (mGluR5) levels are indeed modified in the aging rat hippocampal individual subareas (rat
Autor:
Stefan Hacker, Sabine Spiegl-Kreinecker, Margit Cichna-Markl, Werner Haslik, Georg Pfeiler, Katja Zappe, Christine Pirker, Martin Schreiber, Petra Heffeter, Heidi Miedl
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12527, p 12527 (2021)
Due to its cost-efficiency, high resolution melting (HRM) analysis plays an important role in genotyping of candidate single nucleotide polymorphisms (SNPs). Studies indicate that HRM analysis is not only suitable for genotyping individual SNPs, but
Autor:
Samuel M. Meier-Menches, Ammar Tahir, Katja Zappe, Andrea Bileck, Dominique Kreutz, Margit Cichna-Markl, Christopher Gerner
Publikováno v:
Metallomics. 11:118-127
Activation kinetics of metallo-prodrugs control the types of possible interactions with biomolecules. The intact metallo-prodrug is able to engage with potential targets by purely non-covalent bonding, while the activated metallodrug can form additio