Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Katja Wiechmann"'
Publikováno v:
WE_OS-Jahrbuch, Vol 4, Iss 1 (2021)
Der Ausgangspunkt für die pädagogische Entwicklung an der Universitätsschule Dresden ist die Bestimmung, dass Lernen sich, wie es die kulturhistorische Theorie (u.a. Vygotskij, 2002) bestimmt, im Dialog vollzieht, bzw. wird das Lernen dem Konstruk
Externí odkaz:
https://doaj.org/article/5c60e38961f5410e81e557f36d9f61f1
Autor:
Sarah K Oettl, Jana Gerstmeier, Shafaat Y Khan, Katja Wiechmann, Julia Bauer, Atanas G Atanasov, Clemens Malainer, Ezzat M Awad, Pavel Uhrin, Elke H Heiss, Birgit Waltenberger, Daniel Remias, Johannes M Breuss, Joel Boustie, Verena M Dirsch, Hermann Stuppner, Oliver Werz, Judith M Rollinger
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76929 (2013)
In vitro screening of 17 Alpine lichen species for their inhibitory activity against 5-lipoxygenase, microsomal prostaglandin E2 synthase-1 and nuclear factor kappa B revealed Cetrelia monachorum (Zahlbr.) W.L. Culb. & C.F. Culb. As conceivable sourc
Externí odkaz:
https://doaj.org/article/f45fc10753c74c9f9eca974ae82417db
Publikováno v:
Apoptosis. 20:1508-1517
The acylphloroglucinols hyperforin (Hypf) and myrtucommulone A (MC A) induce death of cancer cells by triggering the intrinsic/mitochondrial pathway of apoptosis, accompanied by a loss of the mitochondrial membrane potential and release of cytochrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b26111b1740102ca0e5f4524b8e9e0
https://doi.org/10.1007/s10495-015-1170-9
https://doi.org/10.1007/s10495-015-1170-9
Publikováno v:
European Journal of Medicinal Chemistry. 101:133-149
The natural acylphloroglucinol myrtucommulone A (1) inhibits microsomal prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), and induces apoptosis of cancer cells. Starting from 1 as lead, 28 analogues were synthesized following a straightf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092654d52d7af52a958af9d4cda58fda
https://doi.org/10.1016/j.ejmech.2015.06.001
https://doi.org/10.1016/j.ejmech.2015.06.001
Autor:
Stefanie König, Oliver Werz, Hans Müller, Katja Wiechmann, Aleš Svatoš, Johann Jauch, Natalie Wielsch
Publikováno v:
Cell chemical biology. 24(5)
The acylphloroglucinol myrtucommulone A (MC) causes mitochondrial dysfunctions by direct interference leading to apoptosis in cancer cells, but the molecular targets involved are unknown. Here, we reveal the chaperonin heat-shock protein 60 (HSP60) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b091d26f640902a3abf27fd7a9bea0
https://pubmed.ncbi.nlm.nih.gov/28457707
https://pubmed.ncbi.nlm.nih.gov/28457707
Autor:
Hermann Stuppner, Gerhard Wolber, Judith M. Rollinger, Daniela Schuster, Julia Bauer, Oliver Werz, Stefan M. Noha, Patrick Markt, Katja Wiechmann, Birgit Waltenberger
Publikováno v:
Journal of Medicinal Chemistry. 54:3163-3174
Microsomal prostaglandin E2 synthase-1 (mPGES-1) catalyzes prostaglandin E2 formation and is considered as a potential anti-inflammatory pharmacological target. To identify novel chemical scaffolds active on this enzyme, two pharmacophore models for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67501fe64d670b72a9ca269ed712883e
https://doi.org/10.1021/jm101309g
https://doi.org/10.1021/jm101309g
Autor:
Oliver Werz, Olga Scherer, Markus Bohnert, Dirk Hoffmeister, Hans-Martin Dahse, Stefanie König, Katja Wiechmann
Publikováno v:
Bioorganicmedicinal chemistry. 22(15)
The melleolides are structurally unique and bioactive natural products of the basidiomycete genus Armillaria. Here, we report on cytotoxic effects of melleolides from Armillaria mellea towards non-transformed human primary monocytes and human cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31048f48547f9cb8348aa7f81f145be2
https://pubmed.ncbi.nlm.nih.gov/25028062
https://pubmed.ncbi.nlm.nih.gov/25028062
Autor:
Atanas G. Atanasov, Katja Wiechmann, Judith M. Rollinger, Sarah K. Oettl, Verena M. Dirsch, Elke H. Heiss, Joël Boustie, J Gerstmeier, H Stuppner, Birgit Waltenberger, Oliver Werz, Julia Bauer
Publikováno v:
Planta Medica. 79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c98eddfcccdf0a1be31958976b6f29
https://doi.org/10.1055/s-0033-1351810
https://doi.org/10.1055/s-0033-1351810
Autor:
Jeffrey S. Barrett, Antonietta Rossi, Katja Wiechmann, Mona Abdel-Tawab, Jan Hüsch, Lidia Sautebin, Jürgen Meins, Carsten Skarke, Kathleen Gerbeth, Oliver Werz, Manfred Schubert-Zsilavecz
Nonsteroidal anti-inflammatory drug intake is associated with a high prevalence of gastrointestinal side effects, and severe cardiovascular adverse reactions challenged the initial enthusiasm in cyclooxygenase-2 inhibitors. Recently, it was shown tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3fb5d5efb58e3389e9085641d058fb
http://hdl.handle.net/11588/558328
http://hdl.handle.net/11588/558328
Autor:
Birgit, Waltenberger, Katja, Wiechmann, Julia, Bauer, Patrick, Markt, Stefan M, Noha, Gerhard, Wolber, Judith M, Rollinger, Oliver, Werz, Daniela, Schuster, Hermann, Stuppner
Publikováno v:
Journal of Medicinal Chemistry
Microsomal prostaglandin E(2) synthase-1 (mPGES-1) catalyzes prostaglandin E(2) formation and is considered as a potential anti-inflammatory pharmacological target. To identify novel chemical scaffolds active on this enzyme, two pharmacophore models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::febb031c3664233f063a2ecde8d4a0e4
https://pubmed.ncbi.nlm.nih.gov/21466167
https://pubmed.ncbi.nlm.nih.gov/21466167