Dynamic mRNP Remodeling in Response to Internal and External Stimuli

Autor: Kathi Zarnack, Sureshkumar Balasubramanian, Michael P. Gantier, Vladislav Kunetsky, Michael Kracht, M. Lienhard Schmitz, Katja Sträßer

Publikováno v: Biomolecules, Vol 10, Iss 9, p 1310 (2020)

Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli

Externí odkaz: https://doaj.org/article/8a4369959d984890b0139c73c648f7ce

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA

Autor: Philipp Keil, Alexander Wulf, Nitin Kachariya, Samira Reuscher, Kristin Hühn, Ivan Silbern, Janine Altmüller, Mario Keller, Ralf Stehle, Kathi Zarnack, Michael Sattler, Henning Urlaub, Katja Sträßer

Publikováno v: Nucleic Acids Research
Nucleic Acids Res. 51, 831-851 (2023)

RNA-binding proteins (RBPs) control every RNA metabolic process by multiple protein–RNA and protein–protein interactions. Their roles have largely been analyzed by crude mutations, which abrogate multiple functions at once and likely impact the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c585a5d1376f78fa1ffa659875841001
https://hdl.handle.net/21.11116/0000-000C-8A2D-721.11116/0000-000C-8A2F-5

From parts lists to functional significance—RNA–protein interactions in gene regulation

Autor: Cornelia Kilchert, Katja Sträßer, Minna-Liisa Änkö, Vladislav Kunetsky

Publikováno v: WIREs RNA

Hundreds of canonical RNA binding proteins facilitate diverse and essential RNA processing steps in cells forming a central regulatory point in gene expression. However, recent discoveries including the identification of a large number of noncanonica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837010e965419cf09a352c0a02769aed

Mechanism and Regulation of Co-transcriptional mRNP Assembly and Nuclear mRNA Export

Autor: Peter Friedhoff, Katja Sträßer, Wolfgang Wende

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9783030314330
The Biology of mRNA: Structure and Function
Advances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology-The Biology of mRNA: Structure and Function

mRNA is the "hermes" of gene expression as it carries the information of a protein-coding gene to the ribosome. Already during its synthesis, the mRNA is bound by mRNA-binding proteins that package the mRNA into a messenger ribonucleoprotein particle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d0d03949b46480ecde5a5e317182d5
https://doi.org/10.1007/978-3-030-31434-7_1

The poly(A)-binding protein Nab2 functions in RNA polymerase III transcription

Autor: Dominik M. Meinel, L. Maximilian Reuter, Katja Sträßer

Publikováno v: Genes & Development. 29:1565-1575

RNA polymerase III (RNAPIII) synthesizes most small RNAs, the most prominent being tRNAs. Although the basic mechanism of RNAPIII transcription is well understood, recent evidence suggests that additional proteins play a role in RNAPIII transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb687135d6259e5e42aad60bc25e94d
https://doi.org/10.1101/gad.266205.115