Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Katja Stifter"'
Autor:
Na Qiu, Akshaya Srikanth, Medhanie Mulaw, Umesh Tharehalli, Shanthiya Selvachandran, Martin Wagner, Thomas Seufferlein, Katja Stifter, André Lechel, Reinhold Schirmbeck
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe expression of viral antigens in chronic hepatitis B virus (HBV) infection drives continuous liver inflammation, one of the main risk factors to develop liver cancer. HBV developed immune-suppressive functions to escape from the host immun
Externí odkaz:
https://doaj.org/article/43a5928ae6104fa09f96ae7fb1b43fc2
Autor:
Dominik Pflumm, Alina Seidel, Fabrice Klein, Rüdiger Groß, Lea Krutzke, Stefan Kochanek, Joris Kroschel, Jan Münch, Katja Stifter, Reinhold Schirmbeck
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
A multitude of alterations in the old immune system impair its functional integrity. Closely related, older individuals show, for example, a reduced responsiveness to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines. However, sys
Externí odkaz:
https://doaj.org/article/1395366881924627908397826e673d79
Autor:
Katja Stifter, Cornelia Schuster, Jana Krieger, Andreas Spyrantis, Bernhard Otto Boehm, Reinhold Schirmbeck
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 12, Iss , Pp 123-133 (2019)
DNA vaccines against autoimmune type 1 diabetes (T1D) contain a nonpredictable risk to induce autoreactive T cell responses rather than a protective immunity. Little is known if (and how) antigen expression and processing requirements favor the induc
Externí odkaz:
https://doaj.org/article/7003fd9174b24d7ea239d6e5ed26751e
Autor:
Johann Gout, Thomas Seufferlein, Alexander Kleger, Katja Stifter, Jana Krieger, Leonie Ruths, Medhanie Mulaw, Andre Lechel, Martin Wagner, Reinhold Schirmbeck
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Many cancer cells express a major histocompatibility complex class I low/ programmed cell death 1 ligand 1 positive (MHC-Ilo/PD-L1+) cell surface profile. For immunotherapy, there is, thus, an urgent need to restore presentation competence
Externí odkaz:
https://doaj.org/article/9f600427fb834004b88c2d0fedc55b38
Autor:
Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Noelia García Rodríguez, Irene de Gracia Herrera Gómez, Esther Fuente-Martin, Livia López-Noriega, José Manuel Mellado-Gil, Silvana-Yanina Romero-Zerbo, Mathurin Baquié, Christian Claude Lachaud, Katja Stifter, German Perdomo, Marco Bugliani, Vincenzo De Tata, Domenico Bosco, Geraldine Parnaud, David Pozo, Abdelkrim Hmadcha, Javier P. Florido, Miguel G. Toscano, Peter de Haan, Kristina Schoonjans, Luis Sánchez Palazón, Piero Marchetti, Reinhold Schirmbeck, Alejandro Martín-Montalvo, Paolo Meda, Bernat Soria, Francisco-Javier Bermúdez-Silva, Luc St-Onge, Benoit R. Gauthier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated
Externí odkaz:
https://doaj.org/article/fbb9d971aff1451c95b83f3e8763290c
Autor:
Michael Karl Melzer, Frank Arnold, Katja Stifter, Friedemann Zengerling, Ninel Azoitei, Thomas Seufferlein, Christian Bolenz, Alexander Kleger
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3345 (2020)
Pancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. Different factors such as mutational landscape, intra- and intertumoral heterogeneity, stroma, and immune cells impact carcinogenesis of PDAC associated with an immunosuppressive m
Externí odkaz:
https://doaj.org/article/973455fd5f3b44eb8bba18748ffbe0f9
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71746 (2013)
Coinhibitory PD-1/PD-L1 (B7-H1) interactions provide critical signals for the regulation of autoreactive T-cell responses. We established mouse models, expressing the costimulator molecule B7.1 (CD80) on pancreatic beta cells (RIP-B7.1 tg mice) or ar
Externí odkaz:
https://doaj.org/article/a700c52b344440fb9c263801b4a1d348
Autor:
Katja Stifter, Thomas Seufferlein, Jana Krieger, Alain Tissot, Iryna Dekhtiarenko, Reinhold Schirmbeck, Martin Wagner
Publikováno v:
Vaccine. 38:3711-3719
Somatic mutations in tumors often generate neoproteins that contain MHC-I-binding neoepitopes. Little is known if and how efficient tumor-specific neoantigens activate CD8+ T cells. Here, we asked whether a de novo generated neoepitope, encoded eithe
Autor:
Hans A. Kestler, Alexander Kleger, Martin Wagner, Diane M. Simeone, Elodie Roger, Karolin Walter, Bruno Sainz, Johann Gout, Pierre Olivier Frappart, Martin Müller, Michaela Ihle, Thomas Seufferlein, André Lechel, Eva Rodriguez-Aznar, Katja Stifter, Johann M. Kraus, Sebastian Müller, Stefan Liebau, Stephanie Biber, Ninel Azoitei, Roland Rad, Mareen Morawe, Lisa Wiesmüller, Sebastian Lange, Andrea Zamperone, Patrick C. Hermann, Stephan A. Hahn, Elisabeth Hessmann, Lukas Perkhofer, Thomas Engleitner, Frank Arnold
Publikováno v:
Gut
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
© Author(s) (or their employer(s)) 2020.
[Objective]: ATM serine/threonine kinase (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC).
[Design
[Objective]: ATM serine/threonine kinase (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC).
[Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724a94ff5a86a7b73ee13280108ec725
https://hdl.handle.net/20.500.14017/5e072fc0-a67f-44b2-9a32-ac27d436a2fe
https://hdl.handle.net/20.500.14017/5e072fc0-a67f-44b2-9a32-ac27d436a2fe
Autor:
Katja, Stifter, Jana, Krieger, Leonie, Ruths, Johann, Gout, Medhanie, Mulaw, Andre, Lechel, Alexander, Kleger, Thomas, Seufferlein, Martin, Wagner, Reinhold, Schirmbeck
Publikováno v:
Journal for Immunotherapy of Cancer
Background Many cancer cells express a major histocompatibility complex class I low/ programmed cell death 1 ligand 1 positive (MHC-Ilo/PD-L1+) cell surface profile. For immunotherapy, there is, thus, an urgent need to restore presentation competence