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pro vyhledávání: '"Katja Schweiger"'
Autor:
Eberhard Scherzinger, Rudi Lurz, Hans Lehrach, Erich E. Wanker, Birgit Hollenbach, Katja Schweiger
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 354(1386)
We have shown previously by electron microscopy that the purified glutathione S-transferase (GST)-Huntington'sdisease (HD) exon 1 fusion protein with 51 glutamine residues (GST-HD51) is an oligomer, and that site-specific proteolytic cleavage of this
Autor:
Hans Lehrach, Gillian P. Bates, Katja Schweiger, Renate Hasenbank, Eberhard Scherzinger, Annie Sittler, Rudi Lurz, Erich E. Wanker, Volker Heiser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 96(8)
Huntington’s disease is a progressive neurodegenerative disorder caused by a polyglutamine [poly(Q)] repeat expansion in the first exon of the huntingtin protein. Previously, we showed that N-terminal huntingtin peptides with poly(Q) tracts in the