Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Katja S. Salmela"'
Publikováno v:
Transfusion. 58(6)
Background Blood transfusion through the intraosseous route is gaining popularity in emergency medicine. Pretransfusion peripheral blood (PB) samples are usually not available in these patients, leading to discrepancies in blood group typing and a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b41f88fec821afdb3db54477cd0a868
https://pubmed.ncbi.nlm.nih.gov/29492974
https://pubmed.ncbi.nlm.nih.gov/29492974
Ethanol-derived Microbial Production of Carcinogenic Acetaldehyde in Achlorhydric Atrophic Gastritis
Autor:
Hannu Nuutinen, Satu Väkeväinen, Mikko Salaspuro, Hannele Jousimies-Somer, Martti Färkkilä, Katja S. Salmela, S. Mentula
Publikováno v:
Scandinavian Journal of Gastroenterology. 37:648-655
Acetaldehyde is a local carcinogen in the digestive tract in humans. Atrophic gastritis leads to microbial colonization of the stomach, which could enhance microbial production of acetaldehyde from ethanol. The aim of the study was to study microbial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28c72c2d776dfa72ceb0dc13c52a3ae
https://doi.org/10.1080/00365520212500
https://doi.org/10.1080/00365520212500
Publikováno v:
Alcoholism: Clinical and Experimental Research. 25:253-260
Background: Recently, we showed that, in addition to cytochrome P-4502E1 (CYP2E1), CYP1A2 and CYP3A4 also contribute to the microsomal ethanol oxidizing system (MEOS). When MEOS activity is measured, sodium azide commonly is used to block the contami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cefb59f442a8154163c87c434f19712a
https://doi.org/10.1111/j.1530-0277.2001.tb02206.x
https://doi.org/10.1111/j.1530-0277.2001.tb02206.x
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:2125-2132
The microsomal ethanol oxidizing system comprises an ethanol-inducible cytochrome P-4502E1, but the involvement of other P-450s has also been suggested. In our study, human CYP2E1, CYP1A2, and CYP3A4 were heterologously expressed in HepG2 cells, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f69305bd2640d273e3e7f04e79aad32
https://doi.org/10.1111/j.1530-0277.1998.tb05926.x
https://doi.org/10.1111/j.1530-0277.1998.tb05926.x
Autor:
Mikko Salaspuro, Risto O. Roine, Katja S. Salmela, Satu Väkeväinen, Pekka Sillanaukee, Liisa Itälä
Publikováno v:
Journal of Laboratory and Clinical Medicine. 129:627-633
Acetaldehyde, the first product of ethanol metabolism, has previously been shown to form potentially harmful adducts with various proteins. The aim of this study was to investigate whether acetaldehyde--either exogenous or metabolically derived--bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179fa6edfdb198c234fbbd2a8807289b
https://doi.org/10.1016/s0022-2143(97)90197-9
https://doi.org/10.1016/s0022-2143(97)90197-9
Publikováno v:
Alcoholism: Clinical and Experimental Research. 20:1011-1015
To evaluate the possible role of catalase in gastric ethanol metabolism in rats, we studied acetaldehyde formation from ethanol by gastric mucosal homogenate under various in vitro conditions. Homogenized rat gastric mucosa produced significant amoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a4c7b97be85b833ffef9ebab65f2fa
https://doi.org/10.1111/j.1530-0277.1996.tb01939.x
https://doi.org/10.1111/j.1530-0277.1996.tb01939.x
Publikováno v:
Life Sciences. 58:1817-1821
Helicobacter pylori contains alcohol dehydrogenase which oxidizes ethanol to acetaldehyde. In the present study, H . pylori cytosol was incubated in a buffered media at pH 6.0 and 7.4 in the presence of ethanol and tryptamine. Under these conditions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8333bc5ab9091946cee34462f64bd503
https://doi.org/10.1016/0024-3205(96)00165-8
https://doi.org/10.1016/0024-3205(96)00165-8
Publikováno v:
Annals of Medicine. 27:583-588
Studies in our laboratory have revealed that Helicobacter pylori exhibits significant cytosolic alcohol dehydrogenase activity and that the enzyme is fully active at ethanol concentrations prevailing in the stomach during alcohol consumption or after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e82cea7735a5569e98d4b80aeb2d42
https://doi.org/10.3109/07853899509002473
https://doi.org/10.3109/07853899509002473
Autor:
Johanna Höök-Nikanne, Mikko Salaspuro, R. Thomas Gentry, Taina Methuen, Timo U. Kosunen, Risto O. Roine, Katja S. Salmela
Publikováno v:
Alcoholism: Clinical and Experimental Research. 18:1294-1299
The organism frequently colonizing the stomach of patients suffering from chronic active gastritis and peptic ulcer disease–Helicobacter pylori–possesses marked alcohol dehydrogenase (ADH) activity. Consequently, Helicobacter infection may contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bd2916a5d8bc481e38a8e1f2eb3d82
https://doi.org/10.1111/j.1530-0277.1994.tb01426.x
https://doi.org/10.1111/j.1530-0277.1994.tb01426.x
Publikováno v:
Scandinavian Journal of Gastroenterology. 29:528-531
We have recently shown that colloidal bismuth subcitrate inhibits cytosolic alcohol dehydrogenase of Helicobacter pylori as well as acetaldehyde production from excess ethanol. We now extend our studies to bismuth subsalicylate and nitecapone, a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0af0216118a70366debb3fc21fee558
https://doi.org/10.3109/00365529409092467
https://doi.org/10.3109/00365529409092467