Assessment of Substrate Status of Drugs Metabolized by Polymorphic Cytochrome P450 (CYP) 2 Enzymes: An Analysis of a Large-Scale Dataset

Autor: Jakob Sommer, Justyna Wozniak, Judith Schmitt, Jana Koch, Julia C. Stingl, Katja S. Just

Publikováno v: Biomedicines, Vol 12, Iss 1, p 161 (2024)

Background: The analysis of substrates of polymorphic cytochrome P450 (CYP) enzymes is important information to enable drug–drug interactions (DDIs) analysis and the relevance of pharmacogenetics in this context in large datasets. Our aim was to co

Externí odkaz: https://doaj.org/article/a031389b7cb84d65b9d788a4da58d5f7

CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized Therapy

Autor: Immaculate M. Langmia, Katja S. Just, Sabrina Yamoune, Jürgen Brockmöller, Collen Masimirembwa, Julia C. Stingl

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality worldwide. It is well-known that individual genetic make-up is one of the causative factors of ADRs. Approximately 14 million single nucleotide polymorphisms (SNPs)

Externí odkaz: https://doaj.org/article/6ea8d76ec19b495e8f188882fb9b788b

Individualized versus Standardized Risk Assessment in Patients at High Risk for Adverse Drug Reactions (The IDrug Randomized Controlled Trial)–Never Change a Running System?

Autor: Katja S. Just, Catharina Scholl, Miriam Boehme, Kathrin Kastenmüller, Johannes M. Just, Markus Bleckwenn, Stefan Holdenrieder, Florian Meier, Klaus Weckbecker, Julia C. Stingl

Publikováno v: Pharmaceuticals, Vol 14, Iss 10, p 1056 (2021)

The aim of this study was to compare effects of an individualized with a standardized risk assessment for adverse drug reactions to improve drug treatment with antithrombotic drugs in older adults. A randomized controlled trial was conducted in gener

Externí odkaz: https://doaj.org/article/840e734802cc46e6bc9db50193174529

Pharmacogenetic and drug interaction aspects on ketamine safety in its use as antidepressant ‐ implications for precision dosing in a global perspective

Autor: Immaculate M. Langmia, Katja S. Just, Sabrina Yamoune, Julian Peter Müller, Julia C. Stingl

Publikováno v: British journal of clinical pharmacology : BJCP 88(12), 5149-5165 (2022). doi:10.1111/bcp.15467 special issue: "Themed Issue: Methodological Consideration in Research and Development of Medicines for Children (C4C / Issue Edited by: Ian Wong, Saskia Dewildt"

British journal of clinical pharmacology : BJCP 88(12), 5149-5165 (2022). doi:10.1111/bcp.15467 special issue: "Themed Issue: Methodological Consideration in Research and Development of Medicines for Children (C4C / Issue Edited by: Ian Wong, Saskia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e63577df5680237f8b3bddf9785871
https://doi.org/10.1111/bcp.15467

Präoperative Medikation: aktuelle Herausforderungen in der Pharmakotherapie

Autor: Katja S Just

Publikováno v: AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie. 56:652-665

Analysis of preoperative medication is used to assess the benefit and risk associated with continuing or discontinuing medication before and during surgery. Identifying adverse drug reactions and assessing its risks often leads to uncertainty. Typica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2631146af29d274060c94e84a51f3527
https://doi.org/10.1055/a-1226-4647