Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy

Autor: Yasmin Yu, Madhumita Bogdan, Muhammad Zaeem Noman, Santiago Parpal, Elisabetta Bartolini, Kris Van Moer, Simone Caroline Kleinendorst, Kristine Bilgrav Saether, Lionel Trésaugues, Camilla Silvander, Johan Lindström, Jodi Simeon, Mary Jane Timson, Hikmat Al‐Hashimi, Bryan D. Smith, Daniel L. Flynn, Andrey Alexeyenko, Jenny Viklund, Martin Andersson, Jessica Martinsson, Katja Pokrovskaja Tamm, Angelo De Milito, Bassam Janji

Publikováno v: Molecular Oncology, Vol 18, Iss 8, Pp 1904-1922 (2024)

An immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have previously reported that inhibition of vacuolar protein sorting 34 (VPS34), a crucial lipid kinase

Externí odkaz: https://doaj.org/article/9dddee620d924c2eb795ae4895e7f6b3

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines

Autor: Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Päivi Östling, Olli P. Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtiö, Mattias Vesterlund, Rozbeh Jafari

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Childhood acute lymphoblastic leukemia is characterised by a range of genetic aberrations. Here, the authors use multi-omics profiling of ALL cell lines to connect molecular phenotypes and drug responses to provide an interactive resource of drug sen

Externí odkaz: https://doaj.org/article/9c69031e6a7f4af09b4fad9d64e4c2b5

Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood KMT2A-rearranged Acute Leukemia

Autor: Mattias Pilheden, Louise Ahlgren, Axel Hyrenius-Wittsten, Veronica Gonzalez-Pena, Helena Sturesson, Hanne Vibeke Hansen Marquart, Birgitte Lausen, Anders Castor, Cornelis Jan Pronk, Gisela Barbany, Katja Pokrovskaja Tamm, Linda Fogelstrand, Olli Lohi, Ulrika Norén-Nyström, Johanna Asklin, Yilun Chen, Guangchun Song, Michael Walsh, Jing Ma, Jinghui Zhang, Lao H. Saal, Charles Gawad, Anna K. Hagström-Andersson

Publikováno v: HemaSphere, Vol 6, Iss 10, p e785 (2022)

Infant acute lymphoblastic leukemia (ALL) with KMT2A-gene rearrangements (KMT2A-r) have few mutations and a poor prognosis. To uncover mutations that are below the detection of standard next-generation sequencing (NGS), a combination of targeted dupl

Externí odkaz: https://doaj.org/article/3d8b60cb5ba24eb4960d6445495d3946

Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy

Autor: Sean G Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, Cynthia BJ Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Julian Walfridsson, Raymond F Schinazi, Baek Kim, Janne Lehtiö, Georgios Z Rassidakis, Katja Pokrovskaja Tamm, Ulrika Warpman‐Berglund, Mats Heyman, Dan Grandér, Sören Lehmann, Thomas Lundbäck, Hong Qian, Jan‐Inge Henter, Torsten Schaller, Thomas Helleday, Nikolas Herold

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 3, Pp 1-20 (2020)

Abstract The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but must be combined with other chemotherapeutics to achieve cure. Yet

Externí odkaz: https://doaj.org/article/ee94cd1a0d794c99b66c9335300d2f1e

Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children

Autor: Svea Stratmann, Mattias Vesterlund, Husen M. Umer, Saeed Eshtad, Aron Skaftason, Morten Krogh Herlin, Christer Sundström, Anna Eriksson, Martin Höglund, Josefine Palle, Jonas Abrahamsson, Kirsi Jahnukainen, Monica Cheng Munthe-Kaas, Bernward Zeller, Katja Pokrovskaja Tamm, Cecilia Lindskog, Lucia Cavelier, Janne Lehtiö, Linda Holmfeldt

Publikováno v: Stratmann, S, Vesterlund, M, Umer, H M, Eshtad, S, Skaftason, A, Herlin, M K, Sundström, C, Eriksson, A, Höglund, M, Palle, J, Abrahamsson, J, Jahnukainen, K, Munthe-Kaas, M C, Zeller, B, Tamm, K P, Lindskog, C, Cavelier, L, Lehtiö, J & Holmfeldt, L 2023, ' Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children ', Leukemia, vol. 37, no. 3, pp. 550–559 . https://doi.org/10.1038/s41375-022-01796-7
Leukemia

Despite improvement of current treatment strategies and novel targeted drugs, relapse and treatment resistance largely determine the outcome for acute myeloid leukemia (AML) patients. To identify the underlying molecular characteristics, numerous stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c56d45cfe983f5e3b153d5cdeae48c2
https://pure.au.dk/portal/da/publications/proteogenomic-analysis-of-acute-myeloid-leukemia-associates-relapsed-disease-with-reprogrammed-energy-metabolism-both-in-adults-and-children(ce2db4d1-e3de-43f1-90c3-0552268840be).html