Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Katja Mohrs"'
Autor:
Lauric Haber, Kara Olson, Marcus P. Kelly, Alison Crawford, David J. DiLillo, Richard Tavaré, Erica Ullman, Shu Mao, Lauren Canova, Olga Sineshchekova, Jennifer Finney, Arpita Pawashe, Supriya Patel, Ryan McKay, Sahar Rizvi, Ermelinda Damko, Danica Chiu, Kristin Vazzana, Priyanka Ram, Katja Mohrs, Amanda D’Orvilliers, Jenny Xiao, Sosina Makonnen, Carlos Hickey, Cody Arnold, Jason Giurleo, Ya Ping Chen, Courtney Thwaites, Drew Dudgeon, Kevin Bray, Ashique Rafique, Tammy Huang, Frank Delfino, Aynur Hermann, Jessica R. Kirshner, Marc W. Retter, Robert Babb, Douglas MacDonald, Gang Chen, William C. Olson, Gavin Thurston, Samuel Davis, John C. Lin, Eric Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumo
Externí odkaz:
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
Autor:
William C. Olson, Alison Crawford, Kara Olson, Jennifer Finney, Ashique Rafique, Kristin Vazzana, Drew Dudgeon, Cody Arnold, Lauren Canova, Eric Smith, Samuel Davis, Gavin Thurston, Ryan McKay, Tammy T. Huang, Danica Chiu, Douglas MacDonald, Sahar Rizvi, Robert Babb, Richard Tavaré, Amanda Dorvilliers, Erica Ullman, Arpita Pawashe, Shu Mao, Ya Ping Chen, Sosina Makonnen, Jenny Xiao, Lauric Haber, Jessica R. Kirshner, Aynur Hermann, Marcus Kelly, Gang Chen, Bray Kevin A, Courtney Thwaites, Carlos Hickey, Olga Sineshchekova, Katja Mohrs, Jason T. Giurleo, Ermelinda Damko, Supriya Patel, John C. Lin, Frank Delfino, Marc W. Retter, Priyanka Ram, Dilillo David
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumor cells.
Autor:
Jessica Kuhnert, Kara Olson, Thomas Startz, Jessica R. Kirshner, Gavin Thurston, Marc W. Retter, Stephen Godin, Dilillo David, Katja Mohrs, Prachi Sharma, Eric Smith, John C. Lin, Olga Sineshchekova, Meagher Thomas Craig, Frank Delfino, Bray Kevin A
Publikováno v:
Blood Adv
CD3-engaging bispecific antibodies (bsAbs) and chimeric antigen receptor (CAR) T cells are potent therapeutic approaches for redirecting patient T cells to recognize and kill tumors. Here we describe a fully human bsAb (REGN5458) that binds to B-cell
Autor:
Corinne E. Decker, Jacqueline Idun, Katja Mohrs, Thomas Meagher, Kevin Bray, Iryna Petriv, Jonathon Golas, Timothy Helms, Dharani Ajithdoss, Gavin Thurston, John Lin, Jessica R. Kirshner, David J. DiLillo
Publikováno v:
Cancer Research. 83:1780-1780
The clinical success of cancer immunotherapy, including engineered T cell therapies, has revolutionized treatment paradigms and patient outcomes. While hematological tumors have benefited most from cell therapy approaches, the treatment of solid tumo
Autor:
Disi An, Guoying Chen, Wei Wang, Katja Mohrs, David DiLillo, Christopher Daly, Gavin Thurston, John Lin, Namita Gupta, Mickey Atwal, Frank Kuhnert
Publikováno v:
Cancer Research. 83:4134-4134
High endothelial venules (HEV) are specialized blood vessels that mediate lymphocyte trafficking to lymph nodes. Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that develop in inflamed, infected or tumoral tissues. TLS contain HEV
Autor:
Alexei V. Tumanov, Jörg H. Fritz, Katja Mohrs, Fanny Tzelepis, Alexandre P. Meli, Elizabeth A. Leadbetter, Markus Mohrs, Paula A. Lanthier, J. Downey, Irah L. King, Maziar Divangahi
Publikováno v:
Mucosal immunology
Homeostasis is a fundamental principle of biological systems. A paradigm of immune homeostasis is the remarkably constant number of naive T and B lymphocytes in the body that continuously circulate through the secondary lymphoid organs to maximize im
Autor:
Aynur Hermann, Gang Chen, Jennifer Finney, Kristin Vazzana, Supriya Patel, Sosina Makonnen, Ya Ping Chen, Lauric Haber, Amanda Dorvilliers, Jessica R. Kirshner, Eric Smith, Robert Babb, Carlos Hickey, Alison Crawford, Jenny Xiao, Jason T. Giurleo, Katja Mohrs, Marcus Kelly, Richard Tavaré, Erica Ullman, Arpita Pawashe, Lauren Canova, Kara Olson, Cody Arnold, Danica Chiu, Marc W. Retter, William C. Olson, Gavin Thurston, Priyanka Ram, Dilillo David, John C. Lin
Publikováno v:
Cancer Research. 80:4555-4555
T-cell redirecting bispecific antibodies are an emerging class of therapeutic agents designed to simultaneously bind to T cells (via CD3) and tumor cell specific antigens (TSA), with the goal of inducing T cell-mediated killing of tumor cells. Despit
Autor:
Bray Kevin A, Katja Mohrs, Olin Gavin Thurston, Kara Olson, Thomas Startz, Marc W. Retter, John C. Lin, T. Craig Meagher, Olga Sineshchekova, Frank Delfino, Jessica R. Kirshner, Stephen Godin, Dilillo David, Eric Smith
Publikováno v:
Blood. 132:1944-1944
Improving therapies for multiple myeloma (MM) remains a high medical need because of the significant morbidity and mortality of the disease. Targeted immunotherapies represent a promising opportunity to fill this clinical need. B cell maturation anti
Publikováno v:
The Journal of Immunology. 185:6138-6145
Pathogen-specific Ab production following infection with the gut-dwelling roundworm Heligmosomoides polygyrus is critical for protective immunity against reinfection. However, the factors required for productive T cell–B cell interactions in the co
Publikováno v:
Nature Immunology. 11:520-526
Cytokines are soluble proteins that regulate immune responses. The present paradigm is that cytokine production in lymphoid tissues is tightly localized and signaling occurs between conjugate cells. Here we assess cytokine signaling during infection