Výsledky vyhledávání - "Katja M Piltti"

Akademický článek

Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair

Autor: Francisca Benavente, Katja M Piltti, Mitra J Hooshmand, Aileen A Nava, Anita Lakatos, Brianna G Feld, Dana Creasman, Paul D Gershon, Aileen Anderson

Publikováno v: eLife, Vol 9 (2020)

C1q plays a key role as a recognition molecule in the immune system, driving autocatalytic complement cascade activation and acting as an opsonin. We have previously reported a non-immune role of complement C1q modulating the migration and fate of hu

Externí odkaz: https://doaj.org/article/0706e4c76cd74a838eb472a9c4dedcbc

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Akademický článek

Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI

Publikováno v: npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-20 (2024)

Abstract Regeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a per

Externí odkaz: https://doaj.org/article/a83ff1b397fa4089b91e5e42b4e4bde0

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Akademický článek

Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury

Autor: Katja M. Piltti, Gabriella M. Funes, Sabrina N. Avakian, Ara A. Salibian, Kevin I. Huang, Krystal Carta, Noriko Kamei, Lisa A. Flanagan, Edwin S. Monuki, Nobuko Uchida, Brian J. Cummings, Aileen J. Anderson

Publikováno v: Stem Cell Reports, Vol 8, Iss 6, Pp 1534-1548 (2017)

Multipotent human central nervous system-derived neural stem cells transplanted at doses ranging from 10,000 (low) to 500,000 (very high) cells differentiated predominantly into the oligodendroglial lineage. However, while the number of engrafted cel

Externí odkaz: https://doaj.org/article/9fa2f646accf495fbb127312df542fdb

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Akademický článek

Transplantation dose alters the dynamics of human neural stem cell engraftment, proliferation and migration after spinal cord injury

Autor: Katja M. Piltti, Sabrina N. Avakian, Gabriella M. Funes, Antoinette Hu, Nobuko Uchida, Aileen J. Anderson, Brian J. Cummings

Publikováno v: Stem Cell Research, Vol 15, Iss 2, Pp 341-353 (2015)

The effect of transplantation dose on the spatiotemporal dynamics of human neural stem cell (hNSC) engraftment has not been quantitatively evaluated in the central nervous system. We investigated changes over time in engraftment/survival, proliferati

Externí odkaz: https://doaj.org/article/1136d545b49c40e9a699d4692a6dc2e2

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Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair

Autor: Mitra J. Hooshmand, Aileen J. Anderson, Brianna G Feld, Francisca Benavente, Dana Creasman, Anita Lakatos, Katja M. Piltti, Paul D. Gershon, Aileen A Nava

Publikováno v: eLife, Vol 9 (2020)
eLife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09f2332984ab1e03090023faa0499ad
https://escholarship.org/uc/item/0cc4f50q

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Author response: Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair

Autor: Brianna G Feld, Mitra J. Hooshmand, Katja M. Piltti, Francisca Benavente, Paul D. Gershon, Aileen A Nava, Aileen J. Anderson, Anita Lakatos, Dana Creasman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c88be9f4b4cd2f4aefa134627af7953
https://doi.org/10.7554/elife.55732.sa2

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Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury

Autor: Katja M. Piltti, Aileen J. Anderson, Rebecca A. Nishi, Mitra J. Hooshmand, Brian J. Cummings

Publikováno v: Anderson, AJ; Piltti, KM; Hooshmand, MJ; Nishi, RA; & Cummings, BJ. (2017). Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury. STEM CELL REPORTS, 8(2), 249-263. doi: 10.1016/j.stemcr.2016.12.018. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0832v2kb
Stem Cell Reports, Vol 8, Iss 2, Pp 249-263 (2017)
Stem Cell Reports

Summary We previously showed the efficacy of multiple research cell lines (RCLs) of human CNS neural stem cells (HuCNS-SCs) in mouse and rat models of thoracic spinal cord injury (SCI), supporting a thoracic SCI clinical trial. Experts recommend in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614d5f5d22f6e8962192b096d4afe0ac

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Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells - Tools for analyzing dynamics of cell cycle, migration, and lineage selection

Autor: Kulbir Singh, Katja M. Piltti, Yuriy Maksymyuk, Colleen L. Worne, Danier Ong, Aileen J. Anderson, Michelle Khine, Brian J. Cummings, Ayla Manughian-Peter, Krystal Carta

Publikováno v: Piltti, KM; Cummings, BJ; Carta, K; Manughian-Peter, A; Worne, CL; Singh, K; et al.(2018). Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells-Tools for analyzing dynamics of cell cycle, migration, and lineage selection. METHODS, 133, 81-90. doi: 10.1016/j.ymeth.2017.10.003. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/95k5t8kz

Neural stem cell (NSC) cultures have been considered technically challenging for time-lapse analysis due to high motility, photosensitivity, and growth at confluent densities. We have tested feasibility of long-term live-cell time-lapse analysis for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5672292b322625fad9a57ca192df187c
http://www.escholarship.org/uc/item/95k5t8kz

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Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis

Autor: Francisca Benavente, Brian J. Cummings, Mitra J. Hooshmand, Lisa A. Flanagan, Nobuko Uchida, Samuel Hong, Katja M. Piltti, Aileen J. Anderson, Hal X. Nguyen

Publikováno v: Hooshmand, MJ; Nguyen, HX; Piltti, KM; Benavente, F; Hong, S; Flanagan, L; et al.(2017). Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis. JOURNAL OF IMMUNOLOGY, 199(3), 1069-1085. doi: 10.4049/jimmunol.1600064. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1k1261kb

Inflammatory processes play a key role in pathophysiology of many neurologic diseases/trauma, but the effect of immune cells and factors on neurotransplantation strategies remains unclear. We hypothesized that cellular and humoral components of innat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63a8bd2ff211e51959dd2b570026509
https://europepmc.org/articles/PMC5523578/

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Safety of Human Neural Stem Cell Transplantation in Chronic Spinal Cord Injury

Autor: Katja M. Piltti, Desirée L. Salazar, Nobuko Uchida, Aileen J. Anderson, Brian J. Cummings

Publikováno v: Piltti, KM; Salazar, DL; Uchida, N; Cummings, BJ; & Anderson, AJ. (2013). Safety of human neural stem cell transplantation in chronic spinal cord injury. Stem Cells Translational Medicine, 2(12), 961-974. doi: 10.5966/sctm.2013-0064. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6q9967s5

The spinal cord injury (SCI) microenvironment undergoes dynamic changes over time, which could potentially affect survival or differentiation of cells in early versus delayed transplantation study designs. Accordingly, assessment of safety parameters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5030985eb85ebe86e80f66a48c06f1e7
https://doi.org/10.5966/sctm.2013-0064

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