Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Katja Möller-Hackbarth"'
Autor:
Emmanuelle Charrin, Dina Dabaghie, Ilke Sen, David Unnersjö-Jess, Katja Möller-Hackbarth, Mikhail Burmakin, Rik Mencke, Sonia Zambrano, Jaakko Patrakka, Hannes Olauson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Transgenic overexpression of αKlotho in hepatocytes results in protection against renal insults, possibly through modulation of the ER stress response by circulating αKlotho. In contrast, αKlotho overexpressed in podocytes is not renoprotective.
Externí odkaz:
https://doaj.org/article/619b3e82d9e24b86ae6db800031da9d4
Autor:
Bing He, Ping Chen, Sonia Zambrano, Dina Dabaghie, Yizhou Hu, Katja Möller-Hackbarth, David Unnersjö-Jess, Gül Gizem Korkut, Emmanuelle Charrin, Marie Jeansson, Maria Bintanel-Morcillo, Anna Witasp, Lars Wennberg, Annika Wernerson, Bernhard Schermer, Thomas Benzing, Patrik Ernfors, Christer Betsholtz, Mark Lal, Rickard Sandberg, Jaakko Patrakka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and high
Externí odkaz:
https://doaj.org/article/fe04160ada134a20a0af7aef65e1f106
Autor:
Guillem Genové, Dina Dabaghie, Jaakko Patrakka, Katja Möller-Hackbarth, Mark Lal, Xidan Li, Annika Wernerson, Sonia Zambrano, Emmanuelle Charrin
Publikováno v:
Kidney International. 100:809-823
Inflammatory pathways are activated in most glomerular diseases but molecular mechanisms driving them in kidney tissue are poorly known. We identified retinoic acid receptor responder 1 (Rarres1) as a highly podocyte-enriched protein in healthy kidne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef24ab6dca4ec5587f0eb43ebbca63f7
https://doi.org/10.1016/j.kint.2021.05.036
https://doi.org/10.1016/j.kint.2021.05.036
Autor:
Jaakko Patrakka, Mark Lal, Annika Östman Wernerson, Xidan Li, Jenny Nyström, Katja Möller-Hackbarth, Sonia Zambrano, Patricia Q. Rodriguez, Angelina Schwarz, Emmanuelle Charrin
Publikováno v:
Journal of the American Society of Nephrology. 30:1573-1586
Background Inflammatory processes play an important role in the pathogenesis of glomerulopathies. Finding novel ways to suppress glomerular inflammation may offer a new way to stop disease progression. However, the molecular mechanisms that initiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32592a520a1918351485d288bc998cd3
https://doi.org/10.1681/asn.2019010089
https://doi.org/10.1681/asn.2019010089
Autor:
Dina Dabaghie, Jaakko Patrakka, Katja Möller-Hackbarth, Hannes Olauson, Emmanuelle Charrin, Rik Mencke, Ilke Sen, Sonia Zambrano
Publikováno v:
Nephrology Dialysis Transplantation. 36
Background and Aims Podocyte integrity is crucial for the maintenance of glomerular function in health and disease. Numerous studies have reported that Klotho overexpression, or treatment with recombinant Klotho, reduces glomerular and tubular damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947726ffe1b21f0a12248f9a31334e6c
https://doi.org/10.1093/ndt/gfab104.0021
https://doi.org/10.1093/ndt/gfab104.0021
Autor:
Gül Gizem Korkut, Katja Möller-Hackbarth, David Unnersjö-Jess, Annika Wernerson, Yizhou Hu, Sonia Zambrano, Marie Jeansson, Rickard Sandberg, Dina Dabaghie, Emmanuelle Charrin, Ping Chen, Lars Wennberg, Thomas Benzing, Patrik Ernfors, Anna Witasp, Christer Betsholtz, Jaakko Patrakka, Bernhard Schermer, Maria Bintanel-Morcillo, Bing He, Mark Lal
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Molecular characterization of the individual cell types in human kidney as well as model organisms are critical in defining organ function and understanding translational aspects of biomedical research. Previous studies have uncovered gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3a4f29f09880dc96b34a15c5c64cda
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455805
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455805
Autor:
Katja Möller-Hackbarth, Jaakko Patrakka, Timo Jahnukainen, David Unnersjö-Jess, Lwaki Ebarasi, Sonia Zambrano, Jing Guo, Patricia Q. Rodriguez, Hans Blom
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Podocytes are critical for the maintenance of kidney ultrafiltration barrier and play a key role in the progression of glomerular diseases. Although mediator complex proteins have been shown to be important for many physiological and pathological pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6891d51735e4fb4c10d202dfcb635b
http://hdl.handle.net/10138/325875
http://hdl.handle.net/10138/325875
Autor:
Jaakko Patrakka, David Unnersjö Jess, Katja Möller-Hackbarth, Angelina Schwarz, Lwaki Ebarasi, Sonia Zambrano, Annika Wernerson, Mark Lal, Hans Blom
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Podocytes have an important role in the pathogenesis of diabetic nephropathy (DN). Podocyte foot process effacement, mediated largely by the actin-based cytoskeleton of foot processes, is commonly detected in DN and is believed to be a key pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddc8aa840554a392aa8629249700a5c
https://doi.org/10.1038/s41598-019-45303-y
https://doi.org/10.1038/s41598-019-45303-y
Autor:
Sonia, Zambrano, Katja, Möller-Hackbarth, Xidan, Li, Patricia Q, Rodriguez, Emmanuelle, Charrin, Angelina, Schwarz, Jenny, Nyström, Annika Östman, Wernerson, Mark, Lal, Jaakko, Patrakka
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Inflammatory processes play an important role in the pathogenesis of glomerulopathies. Finding novel ways to suppress glomerular inflammation may offer a new way to stop disease progression. However, the molecular mechanisms that initiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48baef5aa8798c1ebe734c459072db4d
https://pubmed.ncbi.nlm.nih.gov/31285284
https://pubmed.ncbi.nlm.nih.gov/31285284
Autor:
Andrew L. Croxford, Bernhard Hemmer, Lilian Aly, Stefan Rose-John, Nir Yogev, Tommy Regen, Marina Herwerth, Juan Hidalgo, Christoph Garbers, Stefan Krebs, Thomas Misgeld, Veronika Husterer, Helmut Blum, Thomas Wunderlich, Harald Bartsch, Ari Waisman, Sylvia Heink, Thomas Korn, Karl Sotlar, Mohamed Oukka, Marc Schmidt-Supprian, Katja Möller-Hackbarth, Christiane Gasperi
Publikováno v:
Nature Immunology
The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47c1b1b2da8ba9dfb75a58afa11510f
https://doi.org/10.1038/ni.3632
https://doi.org/10.1038/ni.3632