Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Katja Lammens"'
Autor:
Markus Matthias Hohle, Katja Lammens, Fabian Gut, Bingzhi Wang, Sophia Kahler, Kathrin Kugler, Michael Till, Roland Beckmann, Karl-Peter Hopfner, Christophe Jung
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract While recent technological developments contributed to breakthrough advances in single particle cryo-electron microscopy (cryo-EM), sample preparation remains a significant bottleneck for the structure determination of macromolecular complex
Externí odkaz:
https://doaj.org/article/63856b0cc1234d46a17152757c8a1f1f
Autor:
Felix J. Metzner, Simon J. Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Schlafen 11 serves as an antiviral restriction factor and a predictive biomarker in cancer. Here, the authors use cryoelectron microscopy and biochemical assays to understand tRNA endoribonuclease and DNA binding functions of human Schlafen 11.
Externí odkaz:
https://doaj.org/article/9eba48c415644da8a478dd70a5e2db50
Autor:
Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche, Daniel Krappmann, Katja Lammens
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mut
Externí odkaz:
https://doaj.org/article/22b52c92e3104c5888ae0b4dd5745f98
Autor:
Torben Gehring, Tabea Erdmann, Marco Rahm, Carina Graß, Andrew Flatley, Thomas J. O’Neill, Simone Woods, Isabel Meininger, Ozge Karayel, Kerstin Kutzner, Michael Grau, Hisaaki Shinohara, Katja Lammens, Regina Feederle, Stefanie M. Hauck, Georg Lenz, Daniel Krappmann
Publikováno v:
Cell Reports, Vol 29, Iss 4, Pp 873-888.e10 (2019)
Summary: The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple ser
Externí odkaz:
https://doaj.org/article/de401e662268451888ed66229144888f
Autor:
Thomas Seeholzer, Susanne Kurz, Florian Schlauderer, Simone Woods, Torben Gehring, Simon Widmann, Katja Lammens, Daniel Krappmann
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 pro
Externí odkaz:
https://doaj.org/article/44900b1a0ec8485092c5ae44783ffb2c
Autor:
Charlotte Lässig, Katja Lammens, Jacob Lucián Gorenflos López, Sebastian Michalski, Olga Fettscher, Karl-Peter Hopfner
Publikováno v:
eLife, Vol 7 (2018)
The innate immune sensor retinoic acid-inducible gene I (RIG-I) detects cytosolic viral RNA and requires a conformational change caused by both ATP and RNA binding to induce an active signaling state and to trigger an immune response. Previously, we
Externí odkaz:
https://doaj.org/article/95aad86e8de74fad8fceea1251db4c5a
Autor:
Alfred Lammens, Monika Baehner, Ulrich Kohnert, Jens Niewoehner, Leopold von Proff, Michael Schraeml, Katja Lammens, Karl-Peter Hopfner
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62697 (2013)
The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine playing a key role in tissue regeneration and remodeling. Dysregulation of TWEAK signaling is involved in various pathological processes like autoimmune di
Externí odkaz:
https://doaj.org/article/b1a43aebdf8f49f2bbe2a88a81a89869
Autor:
Stephan Woike, Sebastian Eustermann, James Jung, Simon Josef Wenzl, Götz Hagemann, Joseph Bartho, Katja Lammens, Agata Butryn, Franz Herzog, Karl-Peter Hopfner
Publikováno v:
Nature Structural & Molecular Biology. 30:640-649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b3e538c86d3bb16fd0df531d950b62
https://doi.org/10.1038/s41594-023-00966-0
https://doi.org/10.1038/s41594-023-00966-0
Publikováno v:
Nucleic Acids Research
The Schlafen family belongs to the interferon-stimulated genes and its members are involved in cell cycle regulation, T cell quiescence, inhibition of viral replication, DNA-repair and tRNA processing. Here, we present the cryo-EM structure of full-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd45a92b1ec8be656cedce52c480490d
https://doi.org/10.1093/nar/gkab1278
https://doi.org/10.1093/nar/gkab1278
Autor:
U Pehl, M. Rotheneder, T Fuchß, K. Stakyte, Joseph Bartho, Karl-Peter Hopfner, E van de Logt, Ulrich Grädler, Aaron Alt, Katja Lammens
Publikováno v:
Nature Structural & Molecular Biology. 28:789-798
Human checkpoint kinase ataxia telangiectasia-mutated (ATM) plays a key role in initiation of the DNA damage response following DNA double-strand breaks. ATM inhibition is a promising approach in cancer therapy, but, so far, detailed insights into th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06949eb7c6231fd9627c93a70ad14206
https://doi.org/10.1038/s41594-021-00654-x
https://doi.org/10.1038/s41594-021-00654-x