Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila

Autor: Giuliana D. Clemente, Matthew R. Hannaford, Hamze Beati, Katja Kapp, Jens Januschke, Eric R. Griffis, Hans-Arno J. Müller

Publikováno v: Journal of Developmental Biology, Vol 6, Iss 2, p 9 (2018)

Spindly was originally identified as a specific regulator of Dynein activity at the kinetochore. In early prometaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions and progr

Externí odkaz: https://doaj.org/article/ac3f3d6039784b5999e061fb4acc1450

A Conserved Di‐Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export

Autor: Alexandra Kumichel, Katja Kapp, Elisabeth Knust

Publikováno v: Traffic (Copenhagen, Denmark)

The Drosophila type I transmembrane protein Crumbs is an apical determinant required for the maintenance of apico‐basal epithelial cell polarity. The level of Crumbs at the plasma membrane is crucial, but how it is regulated is poorly understood. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc8f02e5f6cddfd9d05d18bccdf3b87
https://doi.org/10.1111/tra.12273

Lipids Trigger a Conformational Switch That Regulates Signal Recognition Particle (SRP)-mediated Protein Targeting

Autor: Gert Bange, Matthias P. Mayer, Klemens Wild, Christian Graf, Goran Stjepanovic, Richard Parlitz, Katja Kapp, Irmgard Sinning

Publikováno v: Journal of Biological Chemistry. 286:23489-23497

Co-translational protein targeting to the membrane is mediated by the signal recognition particle and its receptor (FtsY). Their homologous GTPase domains interact at the membrane and form a heterodimer in which both GTPases are activated. The prereq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c89e24161580641f17028ffb025478a
https://doi.org/10.1074/jbc.m110.212340

More on Clinical Renal Genetics

Autor: Joost P. H. Drenth, Pierre Ronco, Marie Hubalek Kalbacova, N. Lee, Hiroyasu Tsukaguchi, Stanislav Kmoch, H. Blazkova, Jakub Sikora, Kathleen Claes, Marie Matignon, L. van Keimpema, Z. Chen, Audrey Pawtowski, Jean-Pierre Grünfeld, C. Prost, K. Hodanova, Maud Clemessy, Daniel J. Becker, Emmanuelle Plaisier, J. Zivny, Joel M. Henderson, Johannes Schlondorff, J. Adams, S. Lin, Milan Elleder, P. Favrole, W. Hwu, T. Van Agrmael, S. Chiang, T. Kitagawa, Martin R. Pollak, Philippe Grimbert, Jean Marie Gasc, M. Zivna, Frederik Nevens, H. Hulkova, G. Van Oijen, H. Yeh, M. Chao, Jana Sovová, R. Desnick, Corinne Antignac, Béatrice Marro, R. de Man, L. Hsu, Helena M. Dekker, Katja Kapp, Jean Pierre Fryns, S. Alamovitch, Elizabeth J. Brown, Henry N. Higgs, Evelyne Lerut, Marie-Claire Gubler, Veronika Baresova, Anthony J. Bleyer, Y. Chien, V. Stranecky, A. Uschinski, Ragna Vanslembrouck, A. Huang, P. t Hart, Aswin L. Hoffmann, Petr Vylet'al, Robert Ivanek, R. Dobrovolny, Thomas C. Hart

Publikováno v: Clinical Journal of the American Society of Nephrology, 5, 4, pp. 563-7
Clinical Journal of the American Society of Nephrology, 5, 563-7
Clinical Journal of the American Society of Nephrology, 5, 563-567. American Society of Nephrology

Epidemiologic studies of rare diseases may produce surprising findings and raise ethical issues. This is illustrated in this study performed in 171,977 consecutive Taiwanese newborns (including 90,288 boys) from July 2006 through June 2008 by measuri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0bc281e2aab1243b59dc4a8f6e25c2
https://doi.org/10.2215/cjn.01720210

The Signal Peptide of the Mouse Mammary Tumor Virus Rem Protein Is Released from the Endoplasmic Reticulum Membrane and Accumulates in Nucleoli

Autor: Katja Kapp, Bernhard Dobberstein, Markus Hildenbeutel, Jacob Hochman, Bruno Martoglio, Elisa Dultz

Publikováno v: Journal of Biological Chemistry. 283:9966-9976

N-terminal signal sequences mediate endoplasmic reticulum (ER) targeting and insertion of nascent secretory and membrane proteins and are, in most cases, cleaved off by signal peptidase. The mouse mammary tumor virus envelope protein and its alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01044f411dda15abaa228c8b2e782893
https://doi.org/10.1074/jbc.m705712200