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pro vyhledávání: '"Katja Kallivroussis"'
Autor:
Richard Peck, Elisabeth Husar, Robert Dannecker, Markus Abt, Christoph Wandel, Theo Dinklo, Lucette Doessegger, Katja Kallivroussis, Andreas Rothfuss
Publikováno v:
Clinical Pharmacology and Therapeutics
Traditionally, in dose-escalating first-in-human (FiH) studies, a dose cap with a 10-fold safety margin to the no observed effect level in animals is implemented if convulsive events are observed in animals. However, the convulsive risk seen in anima
Autor:
Abt, Markus, Dinklo, Theo, Rothfuss, Andreas, Husar, Elisabeth, Dannecker, Robert, Kallivroussis, Katja, Peck, Richard, Doessegger, Lucette, Wandel, Christoph
Publikováno v:
Clinical Pharmacology & Therapeutics; Nov2019, Vol. 106 Issue 5, p968-980, 13p