Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Katja Heilmann"'
Publikováno v:
European Journal of Microbiology and Immunology. 2:231-238
Viral proteins are highly antigenic and known as potent stimulators of adaptive immune responses. This mechanism is often used for biotechnological applications in monoclonal antibody production resulting in high-affinity IgG antibodies in most cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1789f6eadc72e3de02b5d53eb81bf2bf
https://doi.org/10.1556/eujmi.2.2012.3.9
https://doi.org/10.1556/eujmi.2.2012.3.9
Autor:
Markus M. Heimesaat, Martin Zeitz, Ulf B. Göbel, R. Farndale, Christian Freise, Stefan Bereswill, Katja Heilmann, M. Rühl, R. Somasundaram, Ulrike Erben, Anja A. Kühl, Andre Fischer
Publikováno v:
European Journal of Microbiology and Immunology. 2:192-200
In experimental models of and humans with intestinal inflammation, increased levels of the matrix-degrading gelatinases MMP-2 and -9 in inflamed tissues can be detected. The synthetic collagen analogue (Gly–Pro–Hyp)10, (GPO)10, has been identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0fa05e483b980daba325794e65eb0b
https://doi.org/10.1556/eujmi.2.2012.3.4
https://doi.org/10.1556/eujmi.2.2012.3.4
Autor:
Humberto Quesada, Kai Postel, Stefanie Hartmann, Karola Lehmann, Katja Heilmann, Heiko Stuckas, Manuela Bartel, Eva Philipp, Burkhard Micheel
Publikováno v:
Marine Biology. 159:2195-2207
Sperm proteins of the marine sessile mussels of the Mytilus edulis species complex are models to investigate reproductive isolation and speciation. This study aimed at identifying sperm proteins and their corresponding genes. This was aided by the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b21c03988c883392e848966664fe57f
https://doi.org/10.1007/s00227-012-2005-7
https://doi.org/10.1007/s00227-012-2005-7
Publikováno v:
Journal of Biotechnology. 156:173-181
The production of monoclonal antibodies by hybridoma technology is dependent on lymphocytes taken from vertebrates which have to be immunized against the corresponding antigen. We present here our first experiments which should allow the replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f998256292a1a0736b381ecfa88987ca
https://doi.org/10.1016/j.jbiotec.2011.09.002
https://doi.org/10.1016/j.jbiotec.2011.09.002
Autor:
Robert Sabat, Christian Sina, Kerstin Wolk, Elianne Tchatchou, Ute Hoffmann, Verena Moos, Katja Heilmann, Pamela Holzlöhner, Ursula Günthert, Stefan Schreiber, C Hayford, Martin Zeitz, Bianca M. Wittig, Ellen Witte, Christoph Loddenkemper
Publikováno v:
Journal of Cellular and Molecular Medicine
Osteopontin (OPN) is characterized as a major amplifier of Th1-immune responses. However, its role in intestinal inflammation is currently unknown. We found considerably raised OPN levels in blood of wild-type (WT) mice with dextran sodium sulfate (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a28372d3653e09842860707d3d445a
http://europepmc.org/articles/PMC4496111
http://europepmc.org/articles/PMC4496111
Publikováno v:
Biochemical Engineering Journal. 35:301-308
The influence of coating polystyrene tissue culture plates with different proteins on murine hybridoma cell growth and antibody production was investigated. Fibronectin, collagen I, bovine serum albumin and laminin were used to coat NUNC® and COSTAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e9683e6d86e26f91e02dd0d2246c83
https://doi.org/10.1016/j.bej.2007.01.035
https://doi.org/10.1016/j.bej.2007.01.035
Autor:
U Günthert, U Wahnschaffe, Andreas Stallmach, Bianca M. Wittig, C Hayford, Ute Hoffmann, Martin Zeitz, Katja Heilmann
Publikováno v:
Cell Death & Differentiation. 14:1542-1551
Deletion of exon CD44v7 abrogates experimental colitis by apoptosis induction in intestinal mononuclear cells. Here we show that CD44v7 expression was upregulated upon CD40 ligation in human mononuclear cells, and examined whether ligation of CD44v7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3b7eee47a8c9ecc619222560b8d9cf
https://doi.org/10.1038/sj.cdd.4402153
https://doi.org/10.1038/sj.cdd.4402153
Isolation of recombinant antibodies from antibody libraries is commonly performed by different molecular display formats including phage display and ribosome display or different cell-surface display formats. We describe a new method which allows the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f3767f8c2586454504d7042abadc55
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/35158
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/35158
Autor:
Katrin Messerschmidt, Katja Heilmann
The generation of antibodies with designated specificity requires cost-intensive and time-consuming screening procedures. Here we present a new method by which hybridoma cells can be selected based on the specificity of the produced antibody by the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a25b1cb2b320bfff42de13a7965ad5
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/35381
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/35381
Autor:
Burkhard Micheel, Katja Heilmann
Publikováno v:
Encyclopedia of Industrial Biotechnology
The hybridoma technology developed from Kohler and Milstein over 20 years ago is till today the scientific standard in generating monoclonal antibodies and demonstrates a hallmark in biotechnology and biomedicine. This basic method and all arising te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a53ed4f8c16062c00a0478bf266389ee
https://doi.org/10.1002/9780470054581.eib037
https://doi.org/10.1002/9780470054581.eib037