Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Katja Harbst"'
Autor:
Martin Lauss, Bengt Phung, Troels Holz Borch, Katja Harbst, Kamila Kaminska, Anna Ebbesson, Ingrid Hedenfalk, Joan Yuan, Kari Nielsen, Christian Ingvar, Ana Carneiro, Karolin Isaksson, Kristian Pietras, Inge Marie Svane, Marco Donia, Göran Jönsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Immune checkpoint blockade (ICB) has improved outcome for patients with metastatic melanoma but not all benefit from treatment. Several immune- and tumor intrinsic features are associated with clinical response at baseline. However, we need
Externí odkaz:
https://doaj.org/article/106ca4c71cf547479bf6c2a98fc56d68
Autor:
Göran Jönsson, Ana Carneiro, Katja Harbst, Christian Ingvar, Teo Helkkula, Gustav Christensen, Karolin Isaksson, Bertil Persson, Åsa Ingvar, Anna Hafström, Viktoria Gaspar, Kari Nielsen
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction Diagnosing invasive cutaneous melanoma (CM) can be challenging due to subjectivity in distinguishing equivocal nevi, melanoma in situ and thin CMs. The underlying molecular mechanisms of progression from nevus to melanoma must be better
Externí odkaz:
https://doaj.org/article/8e96f1a9f6b64d5d9fbe55c503c96b88
Autor:
Marco Donia, Mads H Andersen, Martin Lauss, Göran Jönsson, Arianna Draghi, Katja Harbst, Inge Svane, Torben Lorentzen, Shawez Khan, Mario Presti, Christopher A Chamberlain, Agnete WP Jensen, Michael D Crowther, Anne-Christine K Rasmussen, Benedetta Albieri
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/673109c6c45b49d2b851519064112f0c
Autor:
Adriana Sanna, Bengt Phung, Shamik Mitra, Martin Lauss, Jiyeon Choi, Tongwu Zhang, Ching-Ni Njauw, Eugenia Cordero, Katja Harbst, Frida Rosengren, Rita Cabrita, Iva Johansson, Karolin Isaksson, Christian Ingvar, Ana Carneiro, Kevin Brown, Hensin Tsao, My Andersson, Kristian Pietras, Göran Jönsson
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte-specific gene ex
Externí odkaz:
https://doaj.org/article/37d81ad9a39246c69b971323fad1eabb
Autor:
Kamila Kaminska, Nina Akrap, Johan Staaf, Carla L. Alves, Anna Ehinger, Anna Ebbesson, Ingrid Hedenfalk, Lukas Beumers, Srinivas Veerla, Katja Harbst, Sidse Ehmsen, Signe Borgquist, Åke Borg, Alejandro Pérez-Fidalgo, Henrik J. Ditzel, Ana Bosch, Gabriella Honeth
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-18 (2021)
Abstract Background Resistance to endocrine treatment in metastatic breast cancer is a major clinical challenge. Clinical tools to predict both drug resistance and possible treatment combination approaches to overcome it are lacking. This unmet need
Externí odkaz:
https://doaj.org/article/7cbcb174cf144b08807aab383e525e6b
Autor:
Arianna Draghi, Christopher Aled Chamberlain, Shawez Khan, Krisztian Papp, Martin Lauss, Samuele Soraggi, Haja Dominike Radic, Mario Presti, Katja Harbst, Aishwarya Gokuldass, Anders Kverneland, Morten Nielsen, Marie Christine Wulff Westergaard, Mads Hald Andersen, Istvan Csabai, Göran Jönsson, Zoltan Szallasi, Inge Marie Svane, Marco Donia
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Detecting the entire repertoire of tumor-specific reactive tumor-infiltrating lymphocytes (TILs) is essential for investigating their immunological functions in the tumor microenvironment. Current in vitro assays identifying tumor-specific functional
Externí odkaz:
https://doaj.org/article/656d1c3e4153414e9f09ed73929cd351
Autor:
Marco Donia, Rikke Andersen, Troels Holz Borch, Per Kongsted, Özcan Met, Julie Westerlin Kjeldsen, Morten Nielsen, Magnus Pedersen, Martin Lauss, Göran Jönsson, Inge Marie Svane, Katja Harbst, Aynal Haque Rana, Evelina Martinenaite, Anders Handrup Kverneland, Lisbet Rosenkrantz Hölmich, Helle Hendel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Purpose Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden the applicability of this treat
Externí odkaz:
https://doaj.org/article/441c3fb225154f6cb0e893421b425aa3
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/8ff48f561efa436893e4e83768e62e44
Autor:
Martin Lauss, Marco Donia, Katja Harbst, Rikke Andersen, Shamik Mitra, Frida Rosengren, Maryem Salim, Johan Vallon-Christersson, Therese Törngren, Anders Kvist, Markus Ringnér, Inge Marie Svane, Göran Jönsson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Adoptive T cell therapy (ACT) has yielded high response rates in melanoma, however 50–60% of patients experience no clinical benefit. Here, the authors identify predictive biomarkers, high non-synonymous mutation and high expressed neoantigen load,
Externí odkaz:
https://doaj.org/article/63635278846d435eabbeb4ee5d2c1d15
Autor:
Bengt Phung, Maciej Cieśla, Adriana Sanna, Nicola Guzzi, Giulia Beneventi, Phuong Cao Thi Ngoc, Martin Lauss, Rita Cabrita, Eugenia Cordero, Ana Bosch, Frida Rosengren, Jari Häkkinen, Klaus Griewank, Annette Paschen, Katja Harbst, Håkan Olsson, Christian Ingvar, Ana Carneiro, Hensin Tsao, Dirk Schadendorf, Kristian Pietras, Cristian Bellodi, Göran Jönsson
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3573-3586.e7 (2019)
Summary: The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently altered in various human cancers, including melanomas. Despite its important roles in translation and splicing, how DDX3X dysfunction specifically rewires gene
Externí odkaz:
https://doaj.org/article/f9c312bb787c493281030071690d30e4