The impact of the systemic inflammatory response on hepatic bacterial elimination in experimental abdominal sepsis

Autor: Katja Hanslin, Jan Sjölin, Paul Skorup, Frida Wilske, Robert Frithiof, Anders Larsson, Markus Castegren, Eva Tano, Miklos Lipcsey

Publikováno v: Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Background Bacterial translocation from the gut has been suggested to induce a systemic inflammatory response syndrome (SIRS) and organ dysfunction. The liver has a pivotal role in eliminating circulating bacteria entering from the gut. We i

Externí odkaz: https://doaj.org/article/685b0a774b5b4d7b88efd2a3454687d5

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

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Mazzei, Susanna, Guerrini, Edoardo, Conticini, Luca, Cantarini, Bruno, Frediani, Danilo, Tacconi, Chiara Spertilli Raffaelli, Marco, Feri, Alice, Donati, Raffaele, Scala, Luca, Guidelli, Genni, Spargi, Marta, Corridi, Cesira, Nencioni, Leonardo, Croci, Gian Piero Caldarelli, Maurizio, Spagnesi, Davide, Romani, Paolo, Piacentini, Maria, Bandini, Elena, Desanctis, Silvia, Cappelli, Anna, Canaccini, Agnese, Verzuri, Valentina, Anemoli, Manola, Pisani, Agostino, Ognibene, Alessandro, Pancrazzi, Maria, Lorubbio, Massimo, Vaghi, Antonella, D 'Arminio Monforte, Federica Gaia Miraglia, Mario, U Mondelli, Massimo, Girardis, Sophie, Venturelli, Stefano, Busani, Andrea, Cossarizza, Andrea, Antinori, Alessandra, Vergori, Arianna, Emiliozzi, Stefano, Rusconi, Matteo, Siano, Arianna, Gabrieli, Agostino, Riva, Daniela, Francisci, Elisabetta, Schiaroli, Francesco, Paciosi, Andrea, Tommasi, Pier Giorgio Scotton, Francesca, Andretta, Sandro, Panese, Stefano, Baratti, Renzo, Scaggiante, Francesca, Gatti, 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Berkan-Kawinska, Andrzej, Horban, Justyna, Kowalska, Regina, Podlasin, Piotr, Wasilewski, Arsalin, Azzadin, Miroslaw, Czuczwar, Slawomir, Czaban, Paweł, Olszewski, Jacek, Bogocz, Magdalena, Ochab, Anna, Kruk, Sandra, Uszok, Agnieszka, Bielska, Anna, Szałkowska, Justyna, Raczkowska, Gabriela, Sokołowska, Joanna, Chorostowska-Wynimko, Aleksandra, Jezela-Stanek, Adriana, Roży, Urszula, Lechowicz, Urszula, Polowianiuk, Kamil, Grubczak, Aleksandra, Starosz, Andrzej, Eljaszewicz, Wiktoria, Izdebska, Adam, Krętowski, Robert, Flisiak, Marcin Moniuszko Malak Abedalthagafi Manal Alaamery, Salam, Massadeh, Mohamed, Fawzy, Hadeel, Albardis, Nora, Aljawini, Moneera, Alsuwailm, Faisal, Almalki, Serghei, Mangul, Junghyun, Jung, Hamdi, Mbarek, Chadi, Saad, Yaser, Al-Sarraj, Wadha, Al-Muftah, Radja, Badji, Asma Al Thani, Said, I Ismail

Publikováno v: Human genetics 141 (2021): 147–173. doi:10.1007/s00439-021-02397-7
info:cnr-pdr/source/autori:Fallerini, Chiara; Picchiotti, Nicola; Baldassarri, Margherita; Zguro, Kristina; Daga, Sergio; Fava, Francesca; Benetti, Elisa; Amitrano, Sara; Bruttini, Mirella; Palmieril, Maria; Croci, Susanna; Lista, Mirjam; Beligni, Giada; Valentino, Floriana; Meloni, Ilaria; Tanfoni, Marco; Minnai, Francesca; Colombo, Francesca; Cabri, Enrico; Fratelli, Maddalena; Gabbi, Chiara; Mantovani, Stefania; Frullanti, Elisa; Gori, Marco; Crawley, Francis P.; Butler-Laporte, Guillaume; Richards, Brent; Zeberg, Hugo; Lipcsey, Miklos; Hultstrom, Michael; Ludwig, Kerstin U.; Schulte, Eva C.; Pairo-Castineira, Erola; Baillie, John Kenneth; Schmidt, Axel; Frithiof, Robert; Mari, Francesca; Renieri, Alessandra; Furini, Simone; GEN-COVID Multicenter Study (which includes Alessandra Stella and Filippo Biscarini)/titolo:Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity/doi:10.1007%2Fs00439-021-02397-7/rivista:Human genetics/anno:2021/pagina_da:147/pagina_a:173/intervallo_pagine:147–173/volume:141
Human genetics
Hum. Genet. 141, 147-173 (2022)
Human Genetics
2021, ' Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity ', Human Genetics . https://doi.org/10.1007/s00439-021-02397-7

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4836dbe8027e2289c8e8ff11bfe68cc
https://doi.org/10.1101/2021.09.03.21262611

Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients : A prospective observational study

Autor: Anders Larsson, Robert Frithiof, Michael Hultström, Elena Sancho Ferrando, Katja Hanslin, Miklos Lipcsey

Publikováno v: Cytokine

BACKGROUND: Although pneumonia is the hallmark of coronavirus disease 2019 (COVID-19), multiple organ failure may develop in severe disease. TNFalpha receptors in their soluble form (sTNFR) are involved in the immune cascade in other systemic inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acf80d11bf0c9695e46388481aca910
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455781

The impact of the systemic inflammatory response on hepatic bacterial elimination in experimental abdominal sepsis

Autor: Markus Castegren, Katja Hanslin, Miklos Lipcsey, Anders Larsson, Robert Frithiof, Eva Tano, Paul Skorup, Frida Wilske, Jan Sjölin

Publikováno v: Intensive Care Medicine Experimental
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-15 (2019)

Background Bacterial translocation from the gut has been suggested to induce a systemic inflammatory response syndrome (SIRS) and organ dysfunction. The liver has a pivotal role in eliminating circulating bacteria entering from the gut. We investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b63b23d30ab152d39e3f1c83ebb0ac
https://doi.org/10.1186/s40635-019-0266-x