Výsledky vyhledávání - "Katja Findeisen"

Toward acellular xenogeneic heart valve prostheses: Histological and biomechanical characterization of decellularized and enzymatically deglycosylated porcine pulmonary heart valve matrices

Autor: Katja Findeisen, Robert Ramm, Axel Haverich, Louisa Kolbeck, Hans-Klaus Höffler, Lucrezia Morticelli, Andres Hilfiker, Gudrun Brandes, Sotirios Korossis, Tobias Goecke

Publikováno v: Xenotransplantation. 27

The use of decellularized xenogeneic heart valves might offer a solution to overcome the issue of human valve shortage. The aim of this study was to revise decellularization protocols in combination with enzymatic deglycosylation, in order to reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3965339e1ae6a74e0500b9342772f226
https://doi.org/10.1111/xen.12617

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Decellularization combined with enzymatic removal of N-linked glycans and residual DNA reduces inflammatory response and improves performance of porcine xenogeneic pulmonary heart valves in an ovine in vivo model

Autor: Katja Findeisen, Axel Haverich, Klaus Hoeffler, Samir Sarikouch, Karolina Theodoridis, Robert Ramm, Tobias Goecke, Igor Tudorache, Serghei Cebotari, Andres Hilfiker, Anatol Ciubotaru

Publikováno v: XenotransplantationREFERENCES. 27(2)

Background Limited availability of decellularized allogeneic heart valve substitutes restricts the clinical application thereof. Decellularized xenogeneic valves might constitute an attractive alternative; however, increased immunological hurdles hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51e23a7943b187ad82751efa88b5663
https://pubmed.ncbi.nlm.nih.gov/31769101

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Effects of combined cryopreservation and decellularization on the biomechanical, structural and biochemical properties of porcine pulmonary heart valves

Autor: Axel Haverich, Karolina Theodoridis, Katja Findeisen, Andres Hilfiker, Sotirios Korossis, Robert Ramm, Birgit Andrée, Janina Müller

Publikováno v: Acta Biomaterialia. 43:71-77

Non-fixed, decellularized allogeneic heart valve scaffolds seem to be the best choice for heart valve replacement, their availability, however, is quite limited. Cryopreservation could prolong their shelf-life, allowing for their ideal match to a rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dd9eedb36976686f2e583fbc8b3da0
https://doi.org/10.1016/j.actbio.2016.07.013

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Reduction of xeno-antigens in porcine pulmonary heart valves by decellularization and glycolytic enzymatic treatment

Autor: Tobias Goecke, Axel Haverich, Robert Ramm, Andres Hilfiker, Katja Findeisen

Publikováno v: Xenotransplantation. 21:190-190

Background Heart valve replacement therapy with allogenic decellularized heart valve matrices allows an in vivo autologisation by repopulation of the foreign matrix with autologous cells. This method, which is superior based on experimental evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::393841a6c7a1fd51181facee9acc76a4
https://doi.org/10.1111/xen.12083_13

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Decellularization followed by PNGase F treatment efficiently removes immunogenic αGal epitopes and otherN-acetylglucosamine structures on the glycocalyx of porcine pulmonary heart valve matrices

Autor: Robert Ramm, Andres Hilfiker, Katja Findeisen

Publikováno v: Xenotransplantation. 21:193-193

Background Xenotransplantation leads to hyperacute or acute graft reaction due to interaction of preformed human antibodies, mainly αGal-antibodies, with carbohydrate structures present on non-human tissue. By removing these carbohydrate structures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42cd98140a6de62bd13901da48b9c8ce
https://doi.org/10.1111/xen.12083_19

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