Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Katja Fauster"'
Autor:
Benoit Meyer, Guillaume Bec, Philippe Wolff, Eric Ennifar, Philippe Dumas, Jessica Steger, Marie-Aline Gérard, Dominique Burnouf, Katja Fauster, Ronald Micura
Publikováno v:
Journal of the American Chemical Society. 135:9743-9752
HIV-1 reverse transcriptase (RT) is a heterodimeric enzyme that converts the genomic viral RNA into proviral DNA. Despite intensive biochemical and structural studies, direct thermodynamic data regarding RT interactions with its substrates are still
Autor:
Tobias Santner, Romana Spitzer, Katja Fauster, Martin Tollinger, Christoph H. Wunderlich, Christoph Kreutz
Publikováno v:
Journal of the American Chemical Society. 134:7558-7569
We present a (13)C-based isotope labeling protocol for RNA. Using (6-(13)C)pyrimidine phosphoramidite building blocks, site-specific labels can be incorporated into a target RNA via chemical oligonucleotide solid-phase synthesis. This labeling scheme
Autor:
Eric Ennifar, Katja Fauster, Michaela Aigner, Christoph Kreutz, Tobias Santner, Ronald Micura, Markus Hartl, Klaus Bister
Publikováno v:
ACS Chemical Biology
Chemical modification can significantly enrich the structural and functional repertoire of ribonucleic acids and endow them with new outstanding properties. Here, we report the syntheses of novel 2'-azido cytidine and 2'-azido guanosine building bloc
Autor:
Jessica Steger, Peter Ladurner, Gaetan Borgonie, Katrien De Mulder, Ronald Micura, Daniela Pfister, Katja Fauster, Maxime Willems, Bernhard Egger, Willi Salvenmoser, Georg Kuales
Publikováno v:
Developmental Biology. 334(1):198-212
The flatworm stem cell system is exceptional within the animal kingdom, as totipotent stem cells (neoblasts) are the only dividing cells within the organism. In contrast to most organisms, piwi-like gene expression in flatworms is extended from germ
Autor:
Krista Trappl, Ronald Micura, Katja Fauster, Jessica Steger, Holger Moroder, Dagmar Graber, Viter Márquez, Norbert Polacek, Daniel N. Wilson
Publikováno v:
Angewandte Chemie International Edition. 48:4056-4060
Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especiall
Autor:
Marija, Košutić, Lukas, Jud, Cyrielle, Da Veiga, Marina, Frener, Katja, Fauster, Christoph, Kreutz, Eric, Ennifar, Ronald, Micura
Publikováno v:
Journal of the American Chemical Society
The chemical synthesis of ribonucleic acids (RNA) with novel chemical modifications is largely driven by the motivation to identify eligible functional probes for the various applications in life sciences. To this end, we have a strong focus on the d
Publikováno v:
Angewandte Chemie (International Ed. in English)
Magnetic resonance methods that employ the 19F nucleus for cellular imaging or molecular structure and dynamics investigations become increasingly important for both in vitro and in vivo systems.1 Fluorine is hardly encountered in biomolecules and th
Publikováno v:
Chembiochem
One of the most important scientific discoveries in the recent past concerns RNA interference (RNAi), which is a post-transcriptional gene-silencing mechanism induced by small interfering RNA (siRNA) and micro-RNA (miRNA).[1] RNAi has opened up new a