Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Katja Breitkopf-Heinlein"'
Autor:
Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini, Kim E. Boonekamp, Veronika Hauber, Tobias Gutting, Larissa Frank, Sebastian Belle, Timo Gaiser, Inga Buchholz, Ralf Jesenofsky, Nicolai Härtel, Tianzuo Zhan, Bernd Fischer, Katja Breitkopf-Heinlein, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The heterogeneity underlying cancer organoid phenotypes is not yet well understood. Here, the authors develop an imaging analysis assay for high throughput phenotypic screening of colorectal organoids that allows to define specific morphological chan
Externí odkaz:
https://doaj.org/article/781b445e149e41f2a3b65e3af8beee8f
Autor:
Haristi Gaitantzi, Julius Karch, Lena Germann, Chen Cai, Vanessa Rausch, Emrullah Birgin, Nuh Rahbari, Tatjana Seitz, Claus Hellerbrand, Courtney König, Hellmut G. Augustin, Carolin Mogler, Carolina de la Torre, Norbert Gretz, Timo Itzel, Andreas Teufel, Matthias P. A. Ebert, Katja Breitkopf-Heinlein
Publikováno v:
Cells, Vol 9, Iss 3, p 617 (2020)
It was previously shown that Bone Morphogenetic Protein (BMP)-9 is constitutively produced and secreted by hepatic stellate cells (HSC). Upon acute liver damage, BMP-9 expression is transiently down-regulated and blocking BMP-9 under conditions of ch
Externí odkaz:
https://doaj.org/article/1aa51eca60e245e4af3f0a6e590e9b8a
Autor:
Carolin Mogler, Matthias Wieland, Courtney König, Junhao Hu, Anja Runge, Claudia Korn, Eva Besemfelder, Katja Breitkopf‐Heinlein, Dorde Komljenovic, Steven Dooley, Peter Schirmacher, Thomas Longerich, Hellmut G Augustin
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 332-338 (2015)
Abstract Liver fibrosis is a reversible wound‐healing response to injury reflecting the critical balance between liver repair and scar formation. Chronic damage leads to progressive substitution of liver parenchyma by scar tissue and ultimately res
Externí odkaz:
https://doaj.org/article/7bcb0a855e6a4acc860092533209ee54
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 4, Pp 5199-5220 (2014)
Bone morphogenetic proteins (BMP-2 to BMP-15) belong to the Transforming Growth Factor (TGF)-β superfamily and, besides their well-documented roles during embryogenesis and bone formation, some of them have recently been described to be involved in
Externí odkaz:
https://doaj.org/article/ec194deb830a40978aa39ccfa5f7ccdb
Autor:
Sarada Devi Ramachandran, Katharina Schirmer, Bernhard Münst, Stefan Heinz, Shahrouz Ghafoory, Stefan Wölfl, Katja Simon-Keller, Alexander Marx, Cristina Ionica Øie, Matthias P Ebert, Heike Walles, Joris Braspenning, Katja Breitkopf-Heinlein
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139345 (2015)
In this study we used differentiated adult human upcyte® cells for the in vitro generation of liver organoids. Upcyte® cells are genetically engineered cell strains derived from primary human cells by lenti-viral transduction of genes or gene combi
Externí odkaz:
https://doaj.org/article/dc5d7b5fc1794802915da418ab523b9b
Autor:
Shahrouz Ghafoory, Katja Breitkopf-Heinlein, Qi Li, Catharina Scholl, Steven Dooley, Stefan Wölfl
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78262 (2013)
Zonation of metabolic activities within specific structures and cell types is a phenomenon of liver organization and ensures complementarity of variant liver functions like protein production, glucose homeostasis and detoxification. To analyze damage
Externí odkaz:
https://doaj.org/article/d465f04ab1914cc190ed50b31962b20a
Autor:
H Gaitantzi, Nuh N. Rahbari, Andreas Teufel, Katja Breitkopf-Heinlein, C Cai, Johannes Betge, Norbert Gretz, Emrullah Birgin, Matthias P. Ebert, Carolina De La Torre, Timo Itzel
Publikováno v:
Journal of Cellular and Molecular Medicine
Colorectal cancer (CRC) is a high‐incidence malignancy worldwide which still needs better therapy options. Therefore, the aim of the present study was to investigate the responses of normal or malignant human intestinal epithelium to bone morphogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be7c766125eed28bfa904955cfcca6b
https://doi.org/10.1111/jcmm.17084
https://doi.org/10.1111/jcmm.17084
Autor:
Stephan Drexler, Chen Cai, Anna-Lena Hartmann, Denise Moch, Haristi Gaitantzi, Theresa Ney, Malin Kraemer, Yuan Chu, Yuwei Zheng, Mohammad Rahbari, Annalena Treffs, Alena Reiser, Bénédicte Lenoir, Nektarios A. Valous, Dirk Jäger, Emrullah Birgin, Tejas A. Sawant, Qi Li, Keshu Xu, Lingyue Dong, Mirko Otto, Timo Itzel, Andreas Teufel, Norbert Gretz, Lukas J.A.C. Hawinkels, Aránzazu Sánchez, Blanca Herrera, Rudolf Schubert, Han Moshage, Christoph Reissfelder, Matthias P.A. Ebert, Nuh N. Rahbari, Katja Breitkopf-Heinlein
Publikováno v:
Molecular and Cellular Endocrinology. 570:111934
believed to be mainly produced in the liver. The serum levels of BMP-9 were reported to be reduced in newly diagnosed diabetic patients and BMP-9 overexpression ameliorated steatosis in the high fat diet-induced obesity mouse model. Furthermore, inje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f7a167dc4c18a30e8226c4a4fc6ae6
https://doi.org/10.1016/j.mce.2023.111934
https://doi.org/10.1016/j.mce.2023.111934
Autor:
JoaquinAraos Henriquez, Chen Cai, Qianwen Zhou, Yuwei Zheng, Haristi Gaitantzi, Timo Itzel, Andreas Teufel, LukasHawinkels JAC, Emrullah Birgin, Matthias Ebert, Nuh Rahbari, Katja Breitkopf-Heinlein
Publikováno v:
Zeitschrift für Gastroenterologie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::860d23180ef4a7daa47e2dd3ebe8f751
https://doi.org/10.1055/s-0041-1740783
https://doi.org/10.1055/s-0041-1740783
Publikováno v:
Zeitschrift für Gastroenterologie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdb7bac553eeadbf0f9a34ce8f353b75
https://doi.org/10.1055/s-0041-1740649
https://doi.org/10.1055/s-0041-1740649