Výsledky vyhledávání - "Katja B. Kostelnik"

Akademický článek

Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration.

Autor: Katja B Kostelnik, Amy Barker, Christopher Schultz, Tom P Mitchell, Vinothini Rajeeve, Ian J White, Michel Aurrand-Lions, Sussan Nourshargh, Pedro Cutillas, Thomas D Nightingale

Publikováno v: PLoS Biology, Vol 17, Iss 12, p e3000554 (2019)

Junctional complexes between endothelial cells form a dynamic barrier that hinders passive diffusion of blood constituents into interstitial tissues. Remodelling of junctions is an essential process during leukocyte trafficking, vascular permeability

Externí odkaz: https://doaj.org/article/b2b7cad4d16840fe94d225ada196936e

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Proximity proteomics identifies septin and PAK2 as decisive regulators of actomyosin expulsion of von Willebrand factor

Autor: Sammy El-Mansi, Christopher L. Robinson, Katja B. Kostelnik, Jessica J. McCormack, Tom P. Mitchell, Damián Lobato-Márquez, Vinothini Rajeeve, Pedro Cutillas, Daniel F. Cutler, Serge Mostowy, Thomas D. Nightingale

Publikováno v: Blood.

In response to tissue injury, within seconds the ultra-large glycoprotein von Willebrand factor (VWF) is released from endothelial storage organelles (Weibel−Palade bodies) into the lumen of the blood vasculature, where it leads to the recruitment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c75bea9baf143e489ddc0635875a67
https://pubmed.ncbi.nlm.nih.gov/36564030

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Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration

Autor: Ian J. White, Amy R. Barker, Tom P. Mitchell, Michel Aurrand-Lions, Pedro R. Cutillas, Katja B. Kostelnik, Thomas D. Nightingale, Sussan Nourshargh, Vinothini Rajeeve, Christopher Schultz

Publikováno v: PLoS Biology
PLoS Biology, 2019, 17 (12), pp.e3000554. ⟨10.1371/journal.pbio.3000554⟩
PLoS Biology, Vol 17, Iss 12, p e3000554 (2019)
PLoS Biology, Public Library of Science, 2019, 17 (12), pp.e3000554. ⟨10.1371/journal.pbio.3000554⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46f3dc813a42e5a2c8f1046b107189d
https://www.hal.inserm.fr/inserm-02432807/document

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Dynamic trafficking and turnover of Jam-C is essential for endothelial cell migration

Autor: Amy R. Barker, Pedro R. Cutillas, Katja B. Kostelnik, Michel Aurrand-Lions, Ian J. White, Sussan Nourshargh, Christopher Schultz, Vinothini Rajeeve, Thomas D. Nightingale

Junctional complexes between endothelial cells form a dynamic barrier that hinder passive diffusion of blood constituents into interstitial tissues. Re-modelling of junctions is an essential process during leukocyte trafficking, vascular permeability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5385f4f946e276e04091d82e2ede757c

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Quantitative impedimetric NPY-receptor activation monitoring and signal pathway profiling in living cells

Autor: Heinz-Georg Jahnke, Verena te Kamp, Dana Krinke, Ricco Lindner, Annette G. Beck-Sickinger, Katja B. Kostelnik, Andrea A. Robitzki

Publikováno v: Biosensors and Bioelectronics. 67:386-393

Label-free and non-invasive monitoring of receptor activation and identification of the involved signal pathways in living cells is an ongoing analytic challenge and a great opportunity for biosensoric systems. In this context, we developed an impeda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e427abe98eda0a0a7eda165740f7636
https://doi.org/10.1016/j.bios.2014.08.066

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Quinalizarin inhibits adipogenesis through down-regulation of transcription factors and microRNA modulation

Autor: Mathias Montenarh, Friedrich A. Grässer, Claudia Götz, Lisa Nalbach, Andreas Zimmer, Katja B. Kostelnik, Jennifer Menegatti, Lisa Schwind

Publikováno v: Biochimica et biophysica acta. General subjects. 1861(12)

Background Protein kinase CK2 is induced early in adipogenesis whereas later on, this kinase seems to be dispensable. Here, we have analysed how CK2 might be involved in early steps of differentiation of 3T3-L1 cells. Methods 3T3-L1 cells were differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae2a4af802c341fb93defa3a9aaccd5
https://pubmed.ncbi.nlm.nih.gov/28964816

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A cleavable cytolysin-neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action

Autor: Lutz Weber, Stefan Kalkhof, David Kosel, Katja B. Kostelnik, Annette G. Beck-Sickinger, David Böhme, Martin von Bergen, Robert C. Rennert, Verena M. Ahrens

Publikováno v: Ahrens, V M, Kostelnik, K B, Rennert, R, Böhme, D, Kalkhof, S, Kosel, D, Weber, L, Von Bergen, M & Beck-Sickinger, A G 2015, ' A cleavable cytolysin-neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action ', Journal of Controlled Release, vol. 209, 7658, pp. 170-178 . https://doi.org/10.1016/j.jconrel.2015.04.037

Myxobacterial tubulysins are promising chemotherapeutics inhibiting microtubule polymerization, however, high unspecific toxicity so far prevents their application in therapy. For selective cancer cell targeting, here the coupling of a synthetic cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cb04fe9172d2c951c9e1356a746a0e
https://vbn.aau.dk/da/publications/962ddf9f-8396-4809-a5bc-4243fe13b936

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High metabolic in vivo stability and bioavailability of a palmitoylated ghrelin receptor ligand assessed by mass spectrometry

Autor: Sylvia Els-Heindl, Martin von Bergen, Sven Baumann, Katja B. Kostelnik, Annette G. Beck-Sickinger, Nora Klöting

Publikováno v: Kostelnik, K B, Els-Heindl, S, Kloting, N, Baumann, S, von Bergen, M & Beck-Sickinger, A G 2015, ' High metabolic in vivo stability and bioavailability of a palmitoylated ghrelin receptor ligand assessed by mass spectrometry ', Bioorganic & Medicinal Chemistry, vol. 23, no. 14, pp. 3925–3932 . https://doi.org/10.1016/j.bmc.2014.12.008

The constitutive activity of the ghrelin receptor is of high physiological and pathophysiological relevance. In-depth structure-activity relationship studies revealed a palmitoylated ghrelin receptor ligand that displays an in vitro binding affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642c10597059101c4c9aeb336d217f72
https://vbn.aau.dk/da/publications/3527ee63-3741-49cf-acf0-f0d4126beef0

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Active contractions in single suspended epithelial cells

Autor: Roland Stange, Katja B. Kostelnik, Tobias R Kießling, Mareike Zink, Annette G. Beck-Sickinger, Markus Gyger, Anatol Fritsch, Josef A. Käs

Publikováno v: European biophysics journal : EBJ. 43(1)

Investigations of active contractions in tissue cells to date have been focused on cells that exert forces via adhesion sites to substrates or to other cells. In this study we show that also suspended epithelial cells exhibit contractility, revealing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c3e3d6577c623b09d6b97c0df253c7
https://pubmed.ncbi.nlm.nih.gov/24196420

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Protein kinase CK2 is implicated in early steps of the differentiation of pre-adipocytes into adipocytes

Autor: Mathias Montenarh, Katja B. Kostelnik, Nadine Wilhelm, Claudia Götz

Publikováno v: Molecular and cellular biochemistry. 365(1-2)

Protein kinase CK2 is a ubiquitously expressed serine/threonine kinase which is composed of two catalytic α- or α′-subunits and two non-catalytic β-subunits. CK2 has been shown to be implicated in embryogenesis, spermatogenesis, and the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b76c3e359ae10adb746757e5cdea267
https://pubmed.ncbi.nlm.nih.gov/22270543

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