Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katja Aurbach"'
Autor:
Inga Scheller, Sarah Beck, Vanessa Göb, Carina Gross, Raluca A. I. Neagoe, Katja Aurbach, Markus Bender, David Stegner, Zoltan Nagy, Bernhard Nieswandt
Publikováno v:
Haematologica, Vol 107, Iss 12 (2021)
Coordinated rearrangements of the actin cytoskeleton are pivotal for platelet biogenesis from megakaryocytes but also orchestrate key functions of peripheral platelets in hemostasis and thrombosis, such as granule release, the formation of filopodia
Externí odkaz:
https://doaj.org/article/d892811472c746838adf13f32c2eb97a
Publikováno v:
Platelets, Vol 30, Iss 6, Pp 698-707 (2019)
Inherited or acquired disorders of platelet production and function can result in thrombocytopenia and bleeding. Mouse models have proven useful for investigating the mechanisms that underlie these defects in humans. Precise methods for blood withdra
Externí odkaz:
https://doaj.org/article/9f51ccd9f45d4e7db8cd30ec76c979b9
Autor:
Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Judith M.M. van Eeuwijk, Paquita Nurden, Simon Stritt, Tobias Heib, Katja Aurbach, Oguzhan Angay, Deya Cherpokova, Niels Heinz, Ayesha A. Baig, Maximilian G. Gorelashvili, Frank Gerner, Katrin G. Heinze, Jerry Ware, Georg Krohne, Zaverio M. Ruggeri, Alan T. Nurden, Harald Schulze, Ute Modlich, Irina Pleines, Cord Brakebusch, Bernhard Nieswandt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Düttinget al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting
Externí odkaz:
https://doaj.org/article/9a41c7db2ef649429ea7c2db2ddf72fe
Autor:
Carina Gross, Sarah Beck, Markus Bender, Inga Scheller, Vanessa Göb, Katja Aurbach, David Stegner, Raluca A. I. Neagoe, Zoltan Nagy, Bernhard Nieswandt
Publikováno v:
Haematologica. 107:2846-2858
Coordinated rearrangements of the actin cytoskeleton are pivotal for platelet biogenesis from megakaryocytes but also orchestrate key functions of peripheral platelets in hemostasis and thrombosis, such as granule release, the formation of filopodia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083733bd89746748cdd63fb0aab5b0a5
https://doi.org/10.3324/haematol.2021.278537
https://doi.org/10.3324/haematol.2021.278537
Autor:
Maximilian Englert, Katja Aurbach, Isabelle C. Becker, Annika Gerber, Tobias Heib, Lou M. Wackerbarth, Charly Kusch, Kristina Mott, Gabriel H. M. Araujo, Ayesha A. Baig, Sebastian Dütting, Ulla G. Knaus, Christian Stigloher, Harald Schulze, Bernhard Nieswandt, Irina Pleines, Zoltan Nagy
Publikováno v:
Blood advances. 6(17)
Megakaryocytes are large cells in the bone marrow that give rise to blood platelets. Platelet biogenesis involves megakaryocyte maturation, the localization of the mature cells in close proximity to bone marrow sinusoids, and the formation of protrus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5561274d89202a19d9111fe8bad368
https://pubmed.ncbi.nlm.nih.gov/35819450
https://pubmed.ncbi.nlm.nih.gov/35819450
Autor:
Maximilian Englert, Katja Aurbach, Annika Gerber, Tobias Heib, Isabelle C. Becker, Lou M. Wackerbarth, Charly Kusch, Ayesha A. Baig, Sebastian Dütting, Ulla G. Knaus, Christian Stigloher, Bernhard Nieswandt, Irina Pleines, Zoltan Nagy
Megakaryocytes are large cells in the bone marrow, which give rise to blood platelets. Platelet biogenesis involves megakaryocyte maturation, the localization of mature cells in close proximity to bone marrow sinusoids and the formation of protrusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5accdc4725084be9b4a9b50f4f7c76d4
https://doi.org/10.1101/2021.11.04.467272
https://doi.org/10.1101/2021.11.04.467272
Autor:
Markus Spindler, Markus Bender, Georgi Manukjan, Pekka Lappalainen, Katja Aurbach, Sarah Beck, Zoltan Nagy, Harald Schulze, Carina Gross, Walter Witke, Tobias Heib, Irina Pleines, Bernhard Nieswandt, Lou Martha Wackerbarth, Inga Scheller, Isabelle C. Becker
Publikováno v:
Blood Adv
Rearrangements of the microtubule (MT) and actin cytoskeleton are pivotal for platelet biogenesis. Hence, defects in actin- or MT-regulatory proteins are associated with platelet disorders in humans and mice. Previous studies in mice revealed that lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e4056905be8c9b13981d7fd29e0a0c
https://europepmc.org/articles/PMC7252539/
https://europepmc.org/articles/PMC7252539/
Publikováno v:
Platelets. 30:698-707
Inherited or acquired disorders of platelet production and function can result in thrombocytopenia and bleeding. Mouse models have proven useful for investigating the mechanisms that underlie these defects in humans. Precise methods for blood withdra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ca5ce0e060eae4535835b3543401fb
https://doi.org/10.1080/09537104.2018.1528345
https://doi.org/10.1080/09537104.2018.1528345
Autor:
Katja Aurbach, Sascha Geue, Christoph Kleinschnitz, Harald Schulze, Britta Walker-Allgaier, Oliver Borst, Daniela Semeniak, Madhumita Chatterjee, Irina Pleines, Melanie Märklin, Thierry Buchou, Eva Geuss, Meinrad Gawaz, David Stegner, Patrick Münzer, Helmut R. Salih, David W. Litchfield, Friederike Langhauser, Irene Gonzalez Menendez, Florian Lang, Bernhard Nieswandt, Leticia Quintanilla-Martinez
Publikováno v:
Blood. 130:2774-2785
Platelets, anucleated megakaryocyte (MK)-derived cells, play a major role in hemostasis and arterial thrombosis. Although protein kinase casein kinase 2 (CK2) is readily detected in MKs and platelets, the impact of CK2-dependent signaling on MK/plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dc20cd1d476e7340cfacac240a01dc2
https://doi.org/10.1182/blood-2017-05-784413
https://doi.org/10.1182/blood-2017-05-784413
Autor:
Patrick Münzer, Peter Seizer, Dominik Rath, Harald Schulze, Leticia Quintanilla-Fend, Caroline Brähler, Carla E. Borst, Helmut R. Salih, Tobias Geisler, Meinrad Gawaz, Florian Lang, Sascha Geue, Katja Aurbach, Georgi Manukjan, Oliver Borst, Britta Walker-Allgaier, Bernhard Nieswandt, Irina Pleines, Mailin-Christin Manke, David Stegner, Melanie Märklin
Publikováno v:
Blood. 134(21)
During thrombopoiesis, megakaryocytes (MKs) form proplatelets within the bone marrow (BM) and release platelets into BM sinusoids. Phosphoinositide-dependent protein kinase-1 (PDK1) is required for Ca2+-dependent platelet activation, but its role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40558d87534d0a170f461f2d2c4000a
https://pubmed.ncbi.nlm.nih.gov/31578203
https://pubmed.ncbi.nlm.nih.gov/31578203