Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Katja A Lamia"'
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Disruption of natural light cycles, as experienced by shift workers, is linked to enhanced cancer incidence. Several mouse models of cancer develop more severe disease when exposed to irregular light/dark cycles, supporting the connection
Externí odkaz:
https://doaj.org/article/3d0fcd91667240a7bb67e160dd6c02cf
Autor:
Stephanie J Papp, Anne-Laure Huber, Sabine D Jordan, Anna Kriebs, Madelena Nguyen, James J Moresco, John R Yates III, Katja A Lamia
Publikováno v:
eLife, Vol 4 (2015)
The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect geno
Externí odkaz:
https://doaj.org/article/0a9aa928dda64b9dac1ff996dfe76662
Autor:
Nuria Casanova-Vallve, Drew Duglan, Megan E. Vaughan, Marie Pariollaud, Michal K. Handzlik, Weiwei Fan, Ruth T. Yu, Christopher Liddle, Michael Downes, Julien Delezie, Rebecca Mello, Alanna B. Chan, Pål O. Westermark, Christian M. Metallo, Ronald M. Evans, Katja A. Lamia
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101504- (2022)
Objective: Exercise is a critical component of a healthy lifestyle and a key strategy for the prevention and management of metabolic disease. Identifying molecular mechanisms underlying adaptation in response to chronic physical activity is of critic
Externí odkaz:
https://doaj.org/article/855b431c342f44e185149aa1a1055a2d
Autor:
Marie Pariollaud, Lara H. Ibrahim, Emanuel Irizarry, Rebecca M. Mello, Alanna B. Chan, Brian J. Altman, Reuben J. Shaw, Michael J. Bollong, R. Luke Wiseman, Katja A. Lamia
Publikováno v:
Science Advances. 8
Disrupted circadian rhythmicity is a prominent feature of modern society and has been designated as a probable carcinogen by the World Health Organization. However, the biological mechanisms that connect circadian disruption and cancer risk remain la
Publikováno v:
F1000Research. 12:49
Background: Disruption of natural diurnal light cycles, such as that experienced by shift workers, is linked to enhanced cancer incidence. Several mouse models of cancer have been shown to develop more severe disease when exposed to irregular light/d
Autor:
Katja A. Lamia, Marie Pariollaud
Publikováno v:
Cancer Discov
Circadian rhythms integrate many physiological pathways, helping organisms to align the timing of various internal processes to daily cycles in the external environment. Disrupted circadian rhythmicity is a prominent feature of modern society, and ha
Autor:
Katja A. Lamia, Gian Carlo G. Parico, Michael J. Bollong, Alanna B. Chan, Carrie L. Partch, Jennifer L. Fribourgh, Lara Ibrahim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 27
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Disruption of circadian rhythms increases the risk of several types of cancer. Mammalian cryptochromes (CRY1 and CRY2) are circadian transcriptional repressors that are related to DNA repair enzymes. While CRYs lack DNA repair activity, they modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadc89159164f19472defcc92798b31d
https://escholarship.org/uc/item/1zk672h1
https://escholarship.org/uc/item/1zk672h1
Publikováno v:
Journal of Biological Rhythms. 34:401-409
Circadian clocks allow organisms to anticipate repetitive changes in their environment such as food availability, temperature, and predation. While they most clearly manifest at the behavioral level, driving sleep-wake cycles, for example, they also
Autor:
Katja A. Lamia, Drew Duglan
Publikováno v:
Trends Endocrinol Metab
Research over the past century indicates that the daily timing of physical activity impacts on both immediate performance and long-term training efficacy. Recently, several molecular connections between circadian clocks and exercise physiology have b
Autor:
John R. Yates, Norjin Zolboot, Megan Vaughan, Katja A. Lamia, Valerie Perea, Stephanie Papp Correia, Alanna B. Chan, Anna Kriebs, James J. Moresco, Anne Laure Huber
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
We recently demonstrated that the circadian clock component CRY2 is an essential cofactor in the SCFFBXL3-mediated ubiquitination of c-MYC. Because our demonstration that CRY2 recruits phosphorylated substrates to SCFFBXL3 was unexpected, we investig