Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Katja Gehmlich"'
Autor:
Caitlin Hall, Jonathan P. Law, Jasmeet S. Reyat, Max J. Cumberland, Shaun Hang, Nguyen T. N. Vo, Kavita Raniga, Chris J. Weston, Christopher O’Shea, Jonathan N. Townend, Katja Gehmlich, Charles J. Ferro, Chris Denning, Davor Pavlovic
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Activation of cardiac fibroblasts and differentiation to myofibroblasts underlies development of pathological cardiac fibrosis, leading to arrhythmias and heart failure. Myofibroblasts are characterised by increased α-smooth muscle actin (
Externí odkaz:
https://doaj.org/article/0120de0a24174c8798d8cc3427fd584c
Autor:
Chris Denning, Andrew P Holmes, Katja Gehmlich, Nguyen T N Vo, Paulus Kirchhof, Jonas Euchner, Amar J Azad, Max J Cumberland
Publikováno v:
F1000Research, Vol 12 (2024)
Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomyocytes (hiP
Externí odkaz:
https://doaj.org/article/5188b66493974968b86ab2bed156276c
Autor:
Katja Gehmlich, Stefan Krause
Publikováno v:
Data, Vol 9, Iss 7, p 84 (2024)
Woman scientists have for long been under-represented as recipients of academic prizes. The reasons for this lack of recognition are manifold, including potential gender bias amongst award panels and nomination practices. This dataset of the gender d
Externí odkaz:
https://doaj.org/article/17c379e09f3c4d8282cfcd250d692717
Autor:
Thea Parsberg Støle, Marianne Lunde, Katja Gehmlich, Geir Christensen, William E. Louch, Cathrine Rein Carlson
Publikováno v:
Cells, Vol 13, Iss 11, p 947 (2024)
The transmembrane proteoglycan syndecan-4 is known to be involved in the hypertrophic response to pressure overload. Although multiple downstream signaling pathways have been found to be involved in this response in a syndecan-4-dependent manner, the
Externí odkaz:
https://doaj.org/article/a80e016c709544b3aaf395d5c3d1981e
Autor:
Larissa Fabritz, Lisa Fortmueller, Katja Gehmlich, Sebastian Kant, Marcel Kemper, Dana Kucerova, Fahima Syeda, Cornelius Faber, Rudolf E. Leube, Paulus Kirchhof, Claudia A. Krusche
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 985 (2024)
Desmoglein-2 mutations are detected in 5–10% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Endurance training accelerates the development of the ARVC phenotype, leading to earlier arrhythmic events. Homozygous Dsg2 mutant
Externí odkaz:
https://doaj.org/article/5a5105ab2727484b917460f3f967de2c
Autor:
Chris Denning, Andrew P Holmes, Katja Gehmlich, Nguyen T N Vo, Paulus Kirchhof, Jonas Euchner, Amar J Azad, Max J Cumberland
Publikováno v:
F1000Research, Vol 12 (2023)
Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomyocytes (hiP
Externí odkaz:
https://doaj.org/article/b68b92aa18c34d3196d8b3400e33af08
Autor:
Maya Noureddine, Katja Gehmlich
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the actin-rich thin filaments and plays a crucial role in maintaining
Externí odkaz:
https://doaj.org/article/80822cf26501441c9ee84a1425acfc5d
Autor:
Katja Gehmlich
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 1, Iss , Pp 100009- (2022)
Externí odkaz:
https://doaj.org/article/066c56bc57d14f80bca02f7cb50edee8
Autor:
Max J. Cumberland, Leto L. Riebel, Ashwin Roy, Christopher O’Shea, Andrew P. Holmes, Chris Denning, Paulus Kirchhof, Blanca Rodriguez, Katja Gehmlich
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations linking heart failure and arrhythmias are not fully understood. Historically, research into arrhythmias has been performed on affected individuals or in
Externí odkaz:
https://doaj.org/article/31181414d19e43048af368e9b3094caf
Autor:
Sophie Broadway-Stringer, He Jiang, Kirsty Wadmore, Charlotte Hooper, Gillian Douglas, Violetta Steeples, Amar J. Azad, Evie Singer, Jasmeet S. Reyat, Frantisek Galatik, Elisabeth Ehler, Pauline Bennett, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Benjamin Davies, Kristina Djinovic-Carugo, Mathias Gautel, Hugh Watkins, Katja Gehmlich
Publikováno v:
Cells, Vol 12, Iss 5, p 721 (2023)
Pathogenic variants in ACTN2, coding for alpha-actinin 2, are known to be rare causes of Hypertrophic Cardiomyopathy. However, little is known about the underlying disease mechanisms. Adult heterozygous mice carrying the Actn2 p.Met228Thr variant wer
Externí odkaz:
https://doaj.org/article/0ba42ffd89aa445d9501041c0b0f406d