Výsledky vyhledávání - "Katja, Wosikowski"

Akademický článek

First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery.

Autor: Norbert Pfeiffer, Bogomil Voykov, Giulia Renieri, Katharina Bell, Paul Richter, Melanie Weigel, Hagen Thieme, Barbara Wilhelm, Katrin Lorenz, Martin Feindor, Katja Wosikowski, Michel Janicot, Daniela Päckert, Regina Römmich, Carola Mala, Petra Fettes, Eugen Leo

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188899 (2017)

To evaluate the safety and tolerability of intravitreal ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in patients with primary open angle glaucoma (POAG) undergoing trabeculectomy (TE; glauc

Externí odkaz: https://doaj.org/article/5b269b6322544aeb927497877deed479

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Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis

Autor: Jutta Haunschild, Katja Wosikowski, Carlo Pergola, Jan Seibel, Martin D. Lehner, Oliver Werz, Kirill Kryshen

Publikováno v: Phytomedicine. 22:1172-1177

Background/purpose Acute bronchitis (AB) is a common lung condition characterized by inflammation of the large bronchi in response to infection. Bronchipret® syrup (BRO), a fixed combination of thyme and ivy extracts has been effectively used for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95feb16ca6cd41f14708da3744b6c8f3
https://doi.org/10.1016/j.phymed.2015.09.001

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Preclinical antitumor activity of the oral platinum analog satraplatin

Autor: Faith Kaplan, Gerhard Unteregger, Katja Wosikowski, Maureen Caligiuri, Jimmy P. Xu, Benno Rattel, Volker Jung, Lou Lamphere

Publikováno v: Cancer Chemotherapy and Pharmacology. 60:589-600

Satraplatin is an orally available platinum analog. The purpose of this study was to better characterize satraplatin's preclinical antitumor efficacy in a variety of sensitive and resistant human tumor cell lines and in a prostate cancer xenograft mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a57ce938e66065be9adcbfb3ff7d10f
https://doi.org/10.1007/s00280-007-0502-z

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Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system

Autor: Brigitte Mack, Katja Wosikowski, Bernd Muehlenweg, Suna Ertongur, Olivier Gires, S. Lang

Publikováno v: International Journal of Cancer. 110:815-824

The overall survival rate of patients suffering from carcinomas has remained poor and nearly unchanged over the last decades. This is mainly due to the so-called minimal residual disease, i.e., remaining tumor cells that overcome surgery and/or radio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1eb56f68bfd7574a398d13c4b85be63
https://doi.org/10.1002/ijc.20192

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Modulation of signaling enhances the efficacy of the combination of satraplatin and erlotinib

Autor: Charlotte M. Huijts, Godefridus J. Peters, Auke D. Adema, Gareth J. Veal, Abolfazl Avan, Amir Avan, Eveline K. Hoebe, Katja Wosikowski, Rob Ruijtenbeek

Publikováno v: Current Drug Targets, 15(14), 1312-1321. Bentham Science Publishers B.V.
Scopus-Elsevier
Avan, A, Adema, A D, Hoebe, E K, Huijts, C M, Avan, A, Veal, G J, Ruijtenbeek, R, Wosikowski, K & Peters, G J 2014, ' Modulation of Signaling Enhances the Efficacy of the Combination of Satraplatin and Erlotinib ', Current Drug Targets, vol. 15, no. 14, pp. 1312-1321 . https://doi.org/10.2174/1389450115666141107110321
Current drug targets, 15(14), 1312-1321. Bentham Science Publishers B.V.

The active metabolite (JM118) of the oral platinum analog satraplatin (JM216) was investigated for potential synergism with erlotinib, an epidermal growth factor receptor (EGFR) inhibitor. JM118 sensitivity of 7 cancer cell lines (ovarian: 2008, A278

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9875ce76d8337755183a1538773e0843
https://pubmed.ncbi.nlm.nih.gov/25382189

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Identification of Epidermal Growth Factor Receptor and c-erbB2 Pathway Inhibitors by Correlation With Gene Expression Patterns

Autor: Susan E. Bates, Kenneth D. Paull, Kathryn R. Johnson, John N. Weinstein, Timothy G. Myers, Katja Wosikowski, Danita Schuurhuis

Publikováno v: JNCI Journal of the National Cancer Institute. 89:1505-1515

Background: Growth factor receptor-signaling pathways are potentially important targets for anticancer therapy. The interaction of anticancer agents with specific molecular targets can be identified by correlating target expression patterns with cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bd80fc9b550daf53df0c998f407a8a
https://doi.org/10.1093/jnci/89.20.1505

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Abstract 3741: Antimetastatic activity of ISTH0047, a potent and selective TGF-beta 2 antisense oligonucleotide, in syngeneic lung metastatic model of mouse 4T1 mammary carcinoma

Autor: Guillaume Serin, Marc Hillairet de Boisferon, Sebastian Kreiter, Ugur Sahin, Hanna Kohonen, Jutta Petschenka, Julie-Orlane Redon, Kathy Hasenbach, Michel Janicot, Diana Barea Roldan, Katja Wosikowski, Francis Bichat

Publikováno v: Cancer Research. 76:3741-3741

Transforming growth factor beta (TGF-β) isoforms are the primary mediators for TGF-β signaling via TGF-β receptors and downstream phosphorylation/dephosphorylation cascade. TGF-β is associated with a wide range of biological processes in oncology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f369860a82fc8a3d2bc22115aa10535
https://doi.org/10.1158/1538-7445.am2016-3741

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