Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

Autor: Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor pro

Externí odkaz: https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057

Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C

Autor: Marius W. Baeken, Katja Weckmann, Philip Diefenthäler, Jan Schulte, Kamran Yusifli, Bernd Moosmann, Christian Behl, Parvana Hajieva

Publikováno v: Cells, Vol 9, Iss 10, p 2315 (2020)

Macroautophagy is a conserved degradative process for maintaining cellular homeostasis and plays a key role in aging and various human disorders. The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key

Externí odkaz: https://doaj.org/article/788fc8bc380f44238fc3fb0d79a4e4a7

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

Autor: Nils C, Gassen, Jan, Papies, Thomas, Bajaj, Jackson, Emanuel, Frederik, Dethloff, Robert Lorenz, Chua, Jakob, Trimpert, Nicolas, Heinemann, Christine, Niemeyer, Friderike, Weege, Katja, Hönzke, Tom, Aschman, Daniel E, Heinz, Katja, Weckmann, Tim, Ebert, Andreas, Zellner, Martina, Lennarz, Emanuel, Wyler, Simon, Schroeder, Anja, Richter, Daniela, Niemeyer, Karen, Hoffmann, Thomas F, Meyer, Frank L, Heppner, Victor M, Corman, Markus, Landthaler, Andreas C, Hocke, Markus, Morkel, Nikolaus, Osterrieder, Christian, Conrad, Roland, Eils, Helena, Radbruch, Patrick, Giavalisco, Christian, Drosten, Marcel A, Müller

Publikováno v: Nat Commun
Nature Communications 12(1), 3818 (2021). doi:10.1038/s41467-021-24007-w
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SAR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbe213434fcb363641a7a2287aa8abb
https://hdl.handle.net/21.11116/0000-000A-F8B2-5

Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics

Autor: Jan Papies, Victor M. Corman, Jackson Emanuel, Daniela Niemeyer, Katja Weckmann, Frederik Dethloff, Christian Drosten, M. Lennarz, Anja Richter, Patrick Giavalisco, Nils C. Gassen, Marcel A. Müller, Thomas Bajaj, Daniel E. Heinz, Nicolas Heinemann

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available. Pharmacological modulation of metabolism-dependent cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242bfc55761d0eafb09f5d7845a97e2f

Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C

Autor: Parvana Hajieva, Kamran Yusifli, Philip Diefenthäler, Marius W. Baeken, Katja Weckmann, Bernd Moosmann, Christian Behl, Jan Schulte

Publikováno v: Cells
Volume 9
Issue 10
Cells, Vol 9, Iss 2315, p 2315 (2020)

Macroautophagy is a conserved degradative process for maintaining cellular homeostasis and plays a key role in aging and various human disorders. The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dffbedb117367185d6fa6ce5760911
https://doi.org/10.3390/cells9102315