Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes.

Autor: Saleem U; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., van Meer BJ; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands., Katili PA; Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK., Mohd Yusof NAN; Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK., Mannhardt I; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., Garcia AK; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands., Tertoolen L; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands., de Korte T; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.; Ncardia, 2333 BD, Leiden, The Netherlands., Vlaming MLH; Ncardia, 2333 BD, Leiden, The Netherlands., McGlynn K; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK., Nebel J; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., Bahinski A; GlaxoSmithKline, Collegeville, Pennsylvania 19426., Harris K; NC3Rs, London NW1 2BE, UK., Rossman E; GlaxoSmithKline, Collegeville, Pennsylvania 19426., Xu X; GlaxoSmithKline, Collegeville, Pennsylvania 19426., Burton FL; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK.; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Smith GL; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK.; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Clements P; GlaxoSmithKline, David Jack Centre for R&D, Ware, Hertfordshire SG12 0DP, UK., Mummery CL; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.; Department Applied Stem Cell Technologies, University of Twente, 7500 EA Enschede, The Netherlands., Eschenhagen T; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., Hansen A; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., Denning C; Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2020 Jul 01; Vol. 176 (1), pp. 103-123.

New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models.

Autor: Sharma, Ashish Kumar¹ (AUTHOR) ashishksharma2003@yahoo.com, Singh, Shivam¹ (AUTHOR), Bhat, Mehvish¹ (AUTHOR), Gill, Kartik¹ (AUTHOR), Zaid, Mohammad¹ (AUTHOR), Kumar, Sachin¹ (AUTHOR), Shakya, Anjali¹ (AUTHOR), Tantray, Junaid¹ (AUTHOR), Jose, Divyamol¹ (AUTHOR), Gupta, Rashmi¹ (AUTHOR), Yangzom, Tsering¹ (AUTHOR), Sharma, Rajesh Kumar¹ (AUTHOR), Sahu, Sanjay Kumar² (AUTHOR), Rathore, Gulshan¹ (AUTHOR), Chandolia, Priyanka¹ (AUTHOR), Singh, Mithilesh¹ (AUTHOR), Mishra, Anurag¹ (AUTHOR), Raj, Shobhit¹ (AUTHOR), Gupta, Archita¹ (AUTHOR), Agarwal, Mohit¹ (AUTHOR)

Publikováno v: Scientific Reports. 11/20/2023, Vol. 13 Issue 1, p1-52. 52p.

Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias.

Autor: Wulkan, Fanny, Romagnuolo, Rocco, Beiping Qiang, Valdman Sadikov, Tamilla, Kyung-Phil Kim, Quesnel, Elya, Wenlei Jiang, Andharia, Naaz, Weyers, Jill J., Ghugre, Nilesh R., Ozcan, Bilgehan, Alibhai, Faisal J., Laflamme, Michael A.

Publikováno v: Frontiers in Cardiovascular Medicine; 2024, p01-15, 15p

Carbon nanotubes: a novel innovation as food supplements and biosensing for food safety.

Autor: Masood, Maazallah, Albayouk, Tala, Saleh, Na'il, El-Shazly, Mohamed, El-Nashar, Heba A. S.

Publikováno v: Frontiers in Nutrition; 2024, p1-12, 12p

Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models.

Autor: Jiuru Li¹, Wiesinger, Alexandra¹, Fokkert, Lianne¹, Boukens, Bastiaan J.¹, Verkerk, Arie O.^1,2, Christoffels, Vincent M.¹, Boink, Gerard J. J.^1,3, Devalla, Harsha D.¹ h.d.devalla@amsterdamumc.nl

Publikováno v: Journal of Tissue Engineering. Jan-Dec2022, Vol. 13, p1-18. 18p.