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Autor:
Patricia D. Wilson, Richard Sandford, Ruth L. Case, Xiaohong Li, Catherine A. Boucher, Angela Wandinger-Ness, Heather H. Ward, Christopher J. Ward, Katie S. Thurston, Tamara Roitbak, Andrew Needham, Deborah Hyink, Seema Qamar, Samantha Powell, Elsa Romero
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812:1225-1238
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutation of PKD1 and PKD2 that encode polycystin-1 and polycystin-2. Polycystin-1 is tyrosine phosphorylated and modulates multiple signaling pathways including AP-1, and the identity