Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patients [version 2; peer review: 2 approved]

Autor: Hannah Gagg, Greg Wells, Sarah J. Danson, Spencer J. Collis, Juha Rantala, Ola Rominiyi, Callum Jones, Thomas Helleday, Katie N. Myers, Connor McGarrity-Cottrell, Sophie T. Williams, Samantha Conroy

Publikováno v: F1000Research, Vol 12 (2024)

With diminishing returns and high clinical failure rates from traditional preclinical and animal-based drug discovery strategies, more emphasis is being placed on alternative drug discovery platforms. Ex vivo approaches represent a departure from bot

Externí odkaz: https://doaj.org/article/0d07e3d1808746329649b8bab6580273

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response

Autor: Christopher J. Staples, Giancarlo Barone, Katie N. Myers, Anil Ganesh, Ian Gibbs-Seymour, Abhijit A. Patil, Ryan D. Beveridge, Caroline Daye, Richard Beniston, Sarah Maslen, Ivan Ahel, J. Mark Skehel, Spencer J. Collis

Publikováno v: Cell Reports, Vol 16, Iss 10, Pp 2565-2575 (2016)

Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells. Here, we functionally charact

Externí odkaz: https://doaj.org/article/364b3ced153a49d6af34bb714c11f64b

Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma

Autor: Natasha Carmell, Ola Rominiyi, Spencer J. Collis, Sherif F. El-Khamisy, Eva Perroux-David, Aurelie Vanderlinden, Nikita Lad, Katie N. Myers, Stephen Brown, Connor McGarrity-Cottrell, Malee Fernando, Katherine G. Finegan

Publikováno v: Cancers
Cancers, Vol 13, Iss 944, p 944 (2021)
Carmell, N, Rominiyi, O, Myers, K N, McGarrity-Cottrell, C, Vanderlinden, A, Lad, N, Perroux-David, E, Sherif, A, Fernando, M, Finegan, K, Brown, S & Collis, S 2021, ' Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma ', Cancers, vol. 13, no. 5, 944, pp. 1-14 . https://doi.org/10.3390/cancers13050944
Volume 13
Issue 5

Simple Summary Glioblastomas are high-grade brain tumours and are the most common form of malignancy arising in the brain. Patient survival has improved little over the last 40 years, highlighting an urgent unmet need for more effective treatments fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c387b313b51d584a7ef6e7c0641c94
https://pubmed.ncbi.nlm.nih.gov/33668183

Human CDK18 promotes replication stress signaling and genome stability

Autor: Claire E. Eyers, Patrick A. Eyers, Giancarlo Barone, Karl Patterson, J. Mark Skehel, Abhijit A. Patil, Spencer J. Collis, Katie N. Myers, Sarah L. Maslen, Anil Ganesh, Dominic P. Bryne, Christopher J. Staples

Publikováno v: Nucleic Acids Research

Cyclin-dependent kinases (CDKs) coordinate cell cycle checkpoints with DNA repair mechanisms that together maintain genome stability. However, the myriad mechanisms that can give rise to genome instability are still to be fully elucidated. Here, we i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a0e9c1c6e8e37bf6b3346e445c1799
https://doi.org/10.1093/nar/gkw615

MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer

Autor: Stefan Peter, James W.F. Catto, Ross M. Drayton, Saiful Miah, Katie N. Myers, Helen E. Bryant, Ewa Dudziec

Publikováno v: Oncotarget

// Ross M. Drayton 1 , Stefan Peter 1 , Katie Myers 1 , Saiful Miah 1,2 , Ewa Dudziec 1,2 Helen E. Bryant 1 and James W. F. Catto 1,2 1 Academic Unit of Molecular Oncology, University of Sheffield, UK 2 Academic Urology Unit, University of Sheffield,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c51e070adc26280537a5be80622b9c5
http://europepmc.org/articles/PMC4171637