Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

Autor: Huanjiao Jenny Zhou, Lingfeng Qin, Quan Jiang, Katie N. Murray, Haifeng Zhang, Busu Li, Qun Lin, Morven Graham, Xinran Liu, Jaime Grutzendler, Wang Min

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)

Animal models that fully recapitulate human CCM pathogenesis are not currently available. Here, the authors establish a novel CCM model and reveal that caveolae-Tie2 signaling is involved in CCMs formation at the level of venules, which is accompanie

Externí odkaz: https://doaj.org/article/fb06cd85440d49b9be758e802813c193

Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

Autor: Lingfeng Qin, Haifeng Zhang, Qun Lin, Huanjiao Jenny Zhou, Quan Jiang, Xinran Liu, Katie N. Murray, Wang Min, Busu Li, Morven Graham, Jaime Grutzendler

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)

Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc2e6b33eacfb209bf84ec5caf7d24a
https://doi.org/10.1038/s41467-020-20774-0

Evolution of a maternal immune activation (mIA) model in rats:early developmental effects

Autor: Varsha Mason, Patrick C McHugh, Maurizio Manca, Katie N. Murray, Michael K. Harte, Ben Grayson, Michelle E. Edye, Joanna C. Neill, Eric Prinssen, Reinmar Hager, Anthony C. Vernon, Victoria Fasolino, Joanna M. Oladipo, Irene Knuesel

Publikováno v: Murray, K N, Edye, M E, Manca, M, Vernon, A C, Oladipo, J M, Fasolino, V, Harte, M K, Mason, V, Grayson, B, McHugh, P C, Knuesel, I, Prinssen, E P, Hager, R & Neill, J C 2019, ' Evolution of a maternal immune activation (mIA) model in rats : early developmental effects ', Brain, Behavior, and Immunity, vol. 75, no. 0, pp. 48-59 . https://doi.org/10.1016/j.bbi.2018.09.005
Murray, K N, Edye, M E, Manca, M, Vernon, A C, Oladipo, J M, Fasolino, V, Harte, M K, Mason, V, Grayson, B, Mchugh, P C, Knuesel, I, Prinssen, E P, Hager, R & Neill, J C 2019, ' Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects ', Brain, Behavior, and Immunity, vol. 75, pp. 48-59 . https://doi.org/10.1016/j.bbi.2018.09.005

Maternal immune activation (mIA) in rodents is rapidly emerging as a key model for neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Here, we optimise a mIA model in rats, aiming to address certain limitations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfd0788d57515ad8ac5dfeab3c54494
https://kclpure.kcl.ac.uk/ws/files/101174717/Evolution_of_a_maternal_immune_MURRAY_Firstonline12September2018_GREEN_AAM_CC_BY_NC_ND_.pdf

Streptococcus pneumoniaeworsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα

Autor: Helen Casbolt, Katie N. Murray, David H. Dockrell, Peter Warn, Bazaz Rohit, Bernadett Martinecz, Janet Chamberlain, Adam Denes, Bernhard Nieswandt, Sheila E. Francis, Caroline Drake, Nancy J. Rothwell, Jesús M. Pradillo, Andrew Sharp, Stuart M. Allan

Publikováno v: Annals of Neurology. 75:670-683

OBJECTIVE: Bacterial infection contributes to diverse noninfectious diseases and worsens outcome after stroke. Streptococcus pneumoniae, the most common infection in patients at risk of stroke, is a major cause of prolonged hospitalization and death

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b791be4dc4008b1306c81802b4727b7
https://doi.org/10.1002/ana.24146

18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke

Autor: Renaud Maroy, Katie N. Murray, Paul A. Jones, Alison Smigova, Jesús M. Pradillo, Hervé Boutin, Alexander Gerhard, William Trigg

Publikováno v: Boutin, H, Murray, K, Pradillo, J, Maroy, R, Smigova, A, Gerhard, A, Jones, PA & Trigg, W 2015, ' 18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 42, no. 3, pp. 503-511 . https://doi.org/10.1007/s00259-014-2939-8

PURPOSE: Neuroinflammation plays a critical role in various neuropathological conditions, and hence there is renewed interest in the translocator protein (TSPO) as a biomarker of microglial activation and macrophage infiltration in the brain. This is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a0051c4fbdd4936ef6f9aea313290d
https://www.research.manchester.ac.uk/portal/en/publications/18fge180-a-novel-tspo-radiotracer-compared-to-11crpk11195-in-a-preclinical-model-of-stroke(1780a538-ff01-4a58-a8b0-945147b4c1c5).html