Comparative analysis of potential broad-spectrum neuronal Cre drivers

Autor: Katie M Paton, Jim Selfridge, Jacky Guy, Adrian Bird

Publikováno v: Paton, K M, Selfridge, J, Guy, J & Bird, A 2022, ' Comparative analysis of potential broad-spectrum neuronal Cre drivers ', Wellcome Open Research, vol. 7, no. 185 . https://doi.org/10.12688/wellcomeopenres.17965.1

Cre/Lox technology is a powerful tool in the mouse genetics tool-box as it enables tissue-specific and inducible mutagenesis of specific gene loci. Correct interpretation of phenotypes depends upon knowledge of the Cre expression pattern in the chose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e64a5acab51e66703a5f9621aaf59b6
https://pubmed.ncbi.nlm.nih.gov/35966957

Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders

Autor: Ruth Shah, Catherine M. Abbott, Adrian Bird, Justyna Cholewa-Waclaw, Faith C. J. Davies, Katie M Paton, Ronan Chaligne, Edith Heard

Publikováno v: Shah, R R, Cholewa-Waclaw, J, Davies, F C J, Paton, K M, Chaligne, R, Heard, E, Abbott, C M & Bird, A P 2016, ' Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders ', Wellcome Open Research . https://doi.org/10.12688/wellcomeopenres.10011.1
Wellcome Open Research

The recent identification of multiple new genetic causes of neurological disorders highlights the need for model systems that give experimental access to the underlying biology. In particular, the ability to couple disease-causing mutations with huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f896d29d7be192ac1a7896239e5263eb
https://doi.org/10.12688/wellcomeopenres.10011.1