Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Katie L. Strong"'
Autor:
Hongjie Yuan, Stephen F. Traynelis, Guojun Zhang, Daniel W. Shrey, Wenjuan Chen, Satyanarayana Gedela, Katie L. Strong, Yuchen Xu, Rui Song
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 7, Pp 1480-1494 (2021)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
Objective Genetic variants in the GRIN genes that encode N‐methyl‐D‐aspartate receptor (NMDAR) subunits have been identified in various neurodevelopmental disorders, including epilepsy. We identified a GRIN1 variant from an individual with earl
Autor:
Jing Zhang, Katie L. Strong, Riley E. Perszyk, Chad R. Camp, Kevin K. Ogden, Timothy J. Wilding, Subhrajit Bhattacharya, Dennis C. Liotta, Miranda J. McDaniel, Stephen F. Traynelis, David S. Menaldino, Pieter B. Burger, Tue G. Banke, Matthew P. Epplin, Hiro Kusumoto, Kasper B. Hansen, James E. Huettner, Phuong Le, Thomas M. Kaiser, Gil Shaulsky
Publikováno v:
ACS Chem Neurosci
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic ligand-gated glutamate receptors that mediate fast excitatory synaptic transmission in the central nervous system (CNS). Several neurological disorders may involve NMDAR hypofunction, which has d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d07e01a657441de0ec746261b2976f2
https://europepmc.org/articles/PMC7967294/
https://europepmc.org/articles/PMC7967294/
Autor:
Lynnea D. Harris, Dennis C. Liotta, Ayush Mohan, Katie L. Strong, Phuong Le, Zongjian Zhu, John Bacsa, Matthew P. Epplin, Stephen F. Traynelis, David S. Menaldino
Publikováno v:
J Med Chem
The N-methyl-d-aspartate receptor (NMDAR) is an ion channel that mediates the slow, Ca(2+)-permeable component of glutamatergic synaptic transmission in the central nervous system (CNS). NMDARs are known to play a significant role in basic neurologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829b6ec2070e82af6a5b7e3d70b242e8
https://europepmc.org/articles/PMC7961853/
https://europepmc.org/articles/PMC7961853/
Autor:
John Millichap, Chun Hu, Katie L. Strong, Hongjie Yuan, Hirofumi Kusumoto, Wenjuan Chen, Sharon A. Swanger, Pieter B. Burger, Gordon Wells, Anel Tankovic, Subhrajit Bhattacharya, David R. Adams, Stephen F. Traynelis, Slavé Petrovski, Jing Zhang
Publikováno v:
The American Journal of Human Genetics. 99:1261-1280
Epilepsy and intellectual disability are associated with rare variants in the GluN2A and GluN2B (encoded by GRIN2A and GRIN2B) subunits of the N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel with essential roles in brain development
Autor:
Hirofumi Kusumoto, Eric J. Miller, Steven A. Kell, David S. Menaldino, Bryan Cox, Stephen F. Traynelis, Pieter B. Burger, Dennis C. Liotta, Gil Shaulsky, Katie L. Strong, Matthew P. Epplin, Subhrajit Bhattacharya, Thomas M. Kaiser
Publikováno v:
Molecular pharmacology. 93(2)
N-methyl-d-aspartate (NMDA) receptors are ligand-gated, cation-selective channels that mediate a slow component of excitatory synaptic transmission. Subunit-selective positive allosteric modulators of NMDA receptor function have therapeutically relev
Autor:
Pieter B. Burger, Stephen F. Traynelis, Christopher J. Butch, David S. Menaldino, Matthew P. Epplin, Katie L. Strong, Dennis C. Liotta, John Bacsa
We have identified a series of positive allosteric NMDA receptor (NMDAR) modulators derived from a known class of GluN2C/D-selective tetrahydroisoquinoline analogues that includes CIQ. The prototypical compound of this series contains a single isopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63131cfd6cd7ffd6bc6f11184ebe2bd4
https://europepmc.org/articles/PMC5916808/
https://europepmc.org/articles/PMC5916808/
Publikováno v:
Expert Opinion on Therapeutic Patents. 24:1349-1366
The NMDA receptor mediates a slow component of excitatory synaptic transmission, and NMDA receptor dysfunction has been implicated in numerous neurological disorders. Thus, interest in developing modulators that are capable of regulating the channel
Autor:
Geoffrey A. Vargish, Kevin K. Ogden, Riley E. Perszyk, Yoland Smith, Chris J. McBain, Alpa Khatri, Stephen F. Traynelis, Dennis C. Liotta, Kenneth A. Pelkey, John O. DiRaddo, Chian-Ming Low, Katie L. Strong, Ludovic Tricoire
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2016, 90 (6), pp.689-702. ⟨10.1124/mol.116.105130⟩
Molecular Pharmacology, 2016, 90 (6), pp.689-702. ⟨10.1124/mol.116.105130⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2016, 90 (6), pp.689-702. ⟨10.1124/mol.116.105130⟩
Molecular Pharmacology, 2016, 90 (6), pp.689-702. ⟨10.1124/mol.116.105130⟩
International audience; N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamatergic receptors that have been implicated in learning, development, and neuropathological conditions. They are typically composed of GluN1 and GluN2A-D subunits. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791e9ba3f54df641fa540879117ad930
https://europepmc.org/articles/PMC5118640/
https://europepmc.org/articles/PMC5118640/
Publikováno v:
Allosterism in Drug Discovery ISBN: 9781782624592
The N-methyl-d-aspartate (NMDA) receptor, fundamental for excitatory synaptic transmission, is a tetrameric assembly of two glycine-binding GluN1 subunits and two glutamate-binding GluN2 subunits, of which there are four subtypes (referred to as GluN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff472b917f24abb2de73218c821d4b2b
https://doi.org/10.1039/9781782629276-00281
https://doi.org/10.1039/9781782629276-00281
Autor:
Rose M. Santangelo Freel, Kevin K. Ogden, Stephen F. Traynelis, Katie L. Strong, Henrik Sindal Jensen, Alpa Khatri, Dennis C. Liotta, Kathryn M. Chepiga
Publikováno v:
Journal of Medicinal Chemistry. 56:5351-5381
We describe here the synthesis and evaluation of a series of tetrahydroisoquinolines that show subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. Bischler-Napieralski conditions were employed in the key step fo