Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Katie L Skeffington"'
Autor:
Orhan Uzun, Demetris Taliotis, Umberto Benedetto, Gianni Angelini, Massimo Caputo, Serban Stoica, John Pappachan, Karen Luyt, Mai Baquedano, Deborah A Lawlor, Andrew R Bamber, Gavin J Murphy, Samantha E de Jesus, Andrew D Mumford, Alison Perry, Damien Kenny, Filippo Rapetto, Patricia Caldas, Prashant K Srivastava, Cecilia Gonzalez Corcia, Katie L Skeffington, Ikenna Omeje, Richard J M Coward
Publikováno v:
BMJ Open, Vol 13, Iss 8 (2023)
Introduction Congenital heart disease (CHD) represents the most common birth defect, affecting from 0.4% to 1.2% of children born in developed countries. The survival of these patients has increased significantly, but CHD remains one of the major cau
Externí odkaz:
https://doaj.org/article/85a6351478934dcfa7a5f0088663336f
Autor:
Kirsty L Brain, Beth J Allison, Youguo Niu, Christine M Cross, Nozomi Itani, Andrew D Kane, Emilio A Herrera, Katie L Skeffington, Kimberley J Botting, Dino A Giussani
Publikováno v:
PLoS Biology, Vol 17, Iss 1, p e2006552 (2019)
Evidence derived from human clinical studies and experimental animal models shows a causal relationship between adverse pregnancy and increased cardiovascular disease in the adult offspring. However, translational studies isolating mechanisms to desi
Externí odkaz:
https://doaj.org/article/891649ff31054c8eac304daa17a68641
Autor:
Dominga Iacobazzi, Mohamed T. Ghorbel, Filippo Rapetto, Srinivas A. Narayan, Julia Deutsch, Tasneem Salih, Amy G. Harris, Katie L. Skeffington, Richard Parry, Giulia Parolari, Guillaume Chanoit, Massimo Caputo
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Background: Surgical treatment of congenital heart defects affecting the right ventricular outflow tract (RVOT) often requires complex reconstruction and multiple reoperations due to structural degeneration and lack of growth of currently available m
Externí odkaz:
https://doaj.org/article/018576be975a4df4beb49d2c6bf42bd1
Autor:
Katie L. Skeffington, Ffion P. Jones, M. Saadeh Suleiman, Massimo Caputo, Andrea Brancaccio, Maria Giulia Bigotti
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Background:Mature cardiomyocytes are unable to proliferate, preventing the injured adult heart from repairing itself. Studies in rodents have suggested that the extracellular matrix protein agrin promotes cardiomyocyte proliferation in the developing
Externí odkaz:
https://doaj.org/article/b0670d8f4aaa4035948512c64ac3c363
Autor:
Maria Giulia Bigotti, Katie L. Skeffington, Ffion P. Jones, Massimo Caputo, Andrea Brancaccio
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/f5c5f29bb27c442ba9fa4b6894e0e703
Autor:
Maria Giulia Bigotti, Katie L. Skeffington, Ffion P. Jones, Massimo Caputo, Andrea Brancaccio
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
After cardiac injury, the mammalian adult heart has a very limited capacity to regenerate, due to the inability of fully differentiated cardiomyocytes (CMs) to efficiently proliferate. This has been directly linked to the extracellular matrix (ECM) s
Externí odkaz:
https://doaj.org/article/b5238186e416403fa9e14a7f31973832
Autor:
Tessa A. C. Garrud, Noor E. W. D. Teulings, Youguo Niu, Katie L. Skeffington, Christian Beck, Nozomi Itani, Fiona G. Conlon, Kimberley J. Botting, Lisa M. Nicholas, Wen Tong, Jan B. Derks, Susan E. Ozanne, Dino A. Giussani
Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. The mechanisms underlying off-target effects of the synthetic glucocorticoids mostly used,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056475ba0e8e6e80a9958cad80217790
https://www.repository.cam.ac.uk/handle/1810/349413
https://www.repository.cam.ac.uk/handle/1810/349413
Autor:
Sandra Orgeig, Kirsty L. Brain, Andrew D. Kane, Erin V. McGillick, Emilio A. Herrera, Youguo Niu, Janna L. Morrison, Beth J. Allison, Katie L. Skeffington, Dino A. Giussani, Nozomi Itani
BACKGROUND: In the fetus, the appropriate balance of prooxidants and antioxidants is essential to negate the detrimental effects of oxidative stress on lung maturation. Antioxidants improve respiratory function in postnatal life and adulthood. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869661be071e8a77236e0a79d7c86dc0
Autor:
Katie L. Skeffington, Marco Moscarelli, Safa Abdul-Ghani, Francesca Fiorentino, Costanza Emanueli, Barnaby C. Reeves, Prakash P. Punjabi, Gianni D. Angelini, M-Saadeh Suleiman
Publikováno v:
Frontiers in cardiovascular medicine. 9
IntroductionChanges in cardiac metabolites in adult patients undergoing open-heart surgery using ischemic cardioplegic arrest have largely been reported for non-ventricular tissue or diseased left ventricular tissue, with few studies attempting to as
Autor:
Youguo Niu, Nozomi Itani, Christian Beck, Caroline J. Shaw, Katie L. Skeffington, Dino A. Giussani
Publikováno v:
Hypertension (Dallas, Tex. : 1979)
Supplemental Digital Content is available in the text.
In mammals, pregnancy complicated by chronic hypoxia can program hypertension in the adult offspring. However, mechanisms remain uncertain because the partial contributions of the challenge
In mammals, pregnancy complicated by chronic hypoxia can program hypertension in the adult offspring. However, mechanisms remain uncertain because the partial contributions of the challenge