Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Katie K. Spielbauer"'
Autor:
Andrew M. Breglio, Aaron E. Rusheen, Eric D. Shide, Katharine A. Fernandez, Katie K. Spielbauer, Katherine M. McLachlin, Matthew D. Hall, Lauren Amable, Lisa L. Cunningham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Permanent hearing loss occurs in many cancer patients treated with cisplatin. In this study, the authors examine cisplatin pharmacokinetics in the cochleae of mice and humans showing that cisplatin is retained for months to years after treatment.
Externí odkaz:
https://doaj.org/article/654bf441556b449db69facaa3c80c8f7
Autor:
Chitra, Subramanian, Katie K, Spielbauer, Robin, Pearce, Kevin J, Kovatch, Mark E, Prince, Barbara N, Timmermann, Mark S, Cohen
Publikováno v:
Nutrients; Volume 14; Issue 24; Pages: 5398
Treatment regimens for head and neck squamous cell carcinoma (HNSCC) typically include cisplatin and radiotherapy and are limited by toxicities. We have identified naturally derived withalongolide A triacetate (WGA-TA) from Physalis longifolia as a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5233f5793c210ccac01a8f4940b2a7
https://doi.org/10.3390/nu14245398
https://doi.org/10.3390/nu14245398
Autor:
Claire E Schaar, Dylan J Dues, Katie K Spielbauer, Emily Machiela, Jason F Cooper, Megan Senchuk, Siegfried Hekimi, Jeremy M Van Raamsdonk
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004972 (2015)
Reactive oxygen species (ROS) are highly reactive, oxygen-containing molecules that can cause molecular damage within the cell. While the accumulation of ROS-mediated damage is widely believed to be one of the main causes of aging, ROS also act in si
Externí odkaz:
https://doaj.org/article/a434ee52eb734619b7a9cd5eacfefa8f
Autor:
Andrew J. Rosko, Chaz L. Stucken, Katie K. Spielbauer, Matthew E. Spector, Keith A. Casper, Jumin Sunde, Mark E. Prince, Steven B. Chinn, Kelly M. Malloy, Sathish S. Kumar, Samuel A. Schechtman, Marisa R. Buchakjian
Publikováno v:
Oral oncology. 124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7039b213e1a99378dca3b9d6ff55667
https://pubmed.ncbi.nlm.nih.gov/34481704
https://pubmed.ncbi.nlm.nih.gov/34481704
Autor:
Jeremy M. Van Raamsdonk, Saravanapriah Nadarajan, Jason F. Cooper, Megan M. Senchuk, Monica P. Colaiácovo, Katie K. Spielbauer
Publikováno v:
Experimental Neurology. 310:58-69
Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the formation of α-synuclein-containing protein aggregates called Lewy bodies within the brain. A crucial role for α-synuclein in the pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b624fded2a3358a23173ded325baa02
https://doi.org/10.1016/j.expneurol.2018.09.001
https://doi.org/10.1016/j.expneurol.2018.09.001
Autor:
Jeremy M. Van Raamsdonk, Dylan J. Dues, Megan M. Senchuk, Jason F. Cooper, Emily Machiela, Katie K. Spielbauer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
While the pathogenesis of Parkinson’s disease (PD) is incompletely understood, mitochondrial dysfunction is thought to play a crucial role in disease pathogenesis. Here, we examined the relationship between mitochondrial function and dopamine neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f639b5d16c2786d1044de61459e5738f
http://link.springer.com/article/10.1038/s41598-017-16637-2
http://link.springer.com/article/10.1038/s41598-017-16637-2
Autor:
Aaron E. Rusheen, Lizhen Wang, Katharine A. Fernandez, Lisa L. Cunningham, Stephen J. Eyles, Tiffany G. Baker, Katie K. Spielbauer
Publikováno v:
Hear Res
Cisplatin is used to treat a variety of solid tumors in both children and adults. However, cisplatin has serious side-effects, some of which may permanently affect patients' quality of life following treatment, such as ototoxicity. There is currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33089f67b016c1e7a8aabaa95324a460
https://doi.org/10.1016/j.heares.2020.107905
https://doi.org/10.1016/j.heares.2020.107905
Publikováno v:
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 159(2)
Immune checkpoint inhibition used in combination with standard cisplatin-based chemotherapy regimens is currently under evaluation in clinical trials for head and neck squamous cell carcinoma (HNSCC). The impact of anti–PD-1 therapy on cisplatin-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc3707a6d5acbe381e5f6479d07116a
https://pubmed.ncbi.nlm.nih.gov/29609517
https://pubmed.ncbi.nlm.nih.gov/29609517
Autor:
Aaron E. Rusheen, Katherine M. McLachlin, Katharine A. Fernandez, Andrew M. Breglio, Lauren Amable, Matthew D. Hall, Lisa L. Cunningham, Eric Shide, Katie K. Spielbauer
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Cisplatin chemotherapy causes permanent hearing loss in 40–80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728a1719b8695d7d05102535bb4e54c7
https://doi.org/10.1038/s41467-017-01837-1
https://doi.org/10.1038/s41467-017-01837-1
Autor:
Ruth J. Davis, Carter Van Waes, So Jin Park, Ellen C. Moore, Katie K. Spielbauer, Nicole C. Schmitt, Linda Tran, Clint T. Allen, Roy Xiao
Publikováno v:
Cancer immunology research. 5(12)
Head and neck squamous cell carcinoma (HNSCC) has been treated for decades with cisplatin chemotherapy, and anti–PD-1 immunotherapy has recently been approved for the treatment of this disease. However, preclinical studies of how antitumor immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a1ef68f86bbbbca3e124c5ea8594aa
https://pubmed.ncbi.nlm.nih.gov/29097421
https://pubmed.ncbi.nlm.nih.gov/29097421